KEGG   ENZYME: 1.1.1.187
Entry
EC 1.1.1.187                Enzyme                                 
Name
GDP-4-dehydro-D-rhamnose reductase;
GDP-4-keto-6-deoxy-D-mannose reductase;
GDP-4-keto-D-rhamnose reductase;
guanosine diphosphate-4-keto-D-rhamnose reductase;
GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase;
GDP-6-deoxy-alpha-D-mannose:NAD(P)+ 4-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
GDP-4-dehydro-alpha-D-rhamnose:NAD(P)+ 4-oxidoreductase
Reaction(IUBMB)
(1) GDP-alpha-D-rhamnose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN:R03397 R03399];
(2) GDP-6-deoxy-alpha-D-talose + NAD(P)+ = GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ [RN:R03396 R03398]
Reaction(KEGG)
R03396 R03397 R03398 R03399
Substrate
GDP-alpha-D-rhamnose [CPD:C03117];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
GDP-6-deoxy-alpha-D-talose [CPD:C02977]
Product
GDP-4-dehydro-alpha-D-rhamnose [CPD:C01222];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-alpha-D-rhamnose and its C-4 epimer, GDP-6-deoxy-alpha-D-talose. cf. EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 1.1.1.135, GDP-6-deoxy-D-talose 4-dehydrogenase.
History
EC 1.1.1.187 created 1984
Pathway
ec00051  Fructose and mannose metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
Reference
1  [PMID:4386238]
  Authors
Barber GA.
  Title
The synthesis of guanosine 5'-diphosphate D-rhamnose by enzymes of a higher plant.
  Journal
Biochim Biophys Acta 165:68-75 (1968)
DOI:10.1016/0304-4165(68)90189-X
Reference
2  [PMID:4398966]
  Authors
Winkler NW, Markovitz A.
  Title
Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme.
  Journal
J Biol Chem 246:5868-76 (1971)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.187
IUBMB Enzyme Nomenclature: 1.1.1.187
ExPASy - ENZYME nomenclature database: 1.1.1.187
BRENDA, the Enzyme Database: 1.1.1.187
CAS: 9075-56-3

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (5)   
   KEGG REACTION (4)   
   KEGG RCLASS (1)   
Protein sequence (6)   
   UniProt (6)   
DNA sequence (12)   
   GenBank (6)   
   EMBL (6)   
All databases (35)   

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