Entry
Name
3(or 17)alpha-hydroxysteroid dehydrogenase;
3(17)alpha-hydroxysteroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
androsterone + NAD(P)+ = 5alpha-androstane-3,17-dione + NAD(P)H + H+ [RN:
R02476 R02477 ]
Reaction(KEGG)
Substrate
Product
Comment
Acts on the 3alpha-hydroxy group of androgens of the 5alpha-androstane series; and also, more slowly, on the 17alpha-hydroxy group of both androgenic and estrogenic substrates (cf. EC
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase).
History
EC 1.1.1.209 created 1986
Reference
Authors
Lau PC, Layne DS, Williamson DG.
Title
A 3(17) alpha-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme.
Journal
J Biol Chem 257:9444-9 (1982)
Reference
Authors
Lau PC, Layne DS, Williamson DG.
Title
Comparison of the multiple forms of the soluble 3(17) alpha-hydroxysteroid dehydrogenases of female rabbit kidney and liver.
Journal
J Biol Chem 257:9450-6 (1982)
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.209