KEGG ENZYME: 1.1.1.225

ENZYME: 1.1.1.225

Entry

EC 1.1.1.225                Enzyme

Name

chlordecone reductase;
CDR

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

chlordecone-alcohol:NADP+ 2-oxidoreductase

Reaction(IUBMB)

chlordecone alcohol + NADP+ = chlordecone + NADPH + H+ [RN:R03716]

Reaction(KEGG)

R03716

Substrate

chlordecone alcohol [CPD:C02817];
NADP+ [CPD:C00006]

Product

chlordecone [CPD:C01792];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Chlordecone is an organochlorine pesticide.

History

EC 1.1.1.225 created 1989

Orthology

K00037

3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase

Genes

HSA:	1109(AKR1C4)

PTR:	450274(AKR1C4)

PPS:	100987989(AKR1C4)

GGO:

101148343

PON:	100434557(AKR1C4)

NLE:

100605385

HMH:	116461800(AKR1C4)

MCC:	722483 722490(AKR1C4)

MCF:	102116844 102117205(AKR1C4)

MTHB:

126963007

MNI:

105490779

CSAB:

103237814

CATY:

105597444 105597447

PANU:

101022938

TGE:

112631314

MLEU:

105535763

RRO:

104674748

RBB:

108521035

TFN:	117082119 117082359

CANG:

105521699 105521705

CJC:	100405255 100405615(AKR1C4)

SBQ:

101041915

CIMI:

108292324(AKR1C4) 108292325

OGA:

100940488

MMMA:

107150202

GVR:

103581518

ECB:

100057251

EPZ:

103540777

EAI:

106827243

LAV:

100660861

DNM:

101426998

XLA:	108712557(akr1c4.S)

XTR:	496490(akr1c4)

NPR:

108799292

RTEM:

120932842

BBUF:

121003666

BGAR:

122926607

» show all

Reference

1 [PMID:2427522]

Authors

Molowa DT, Shayne AG, Guzelian PS.

Title

Purification and characterization of chlordecone reductase from human liver.

Journal

J Biol Chem 261:12624-7 (1986)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.225

IUBMB Enzyme Nomenclature:

1.1.1.225

ExPASy - ENZYME nomenclature database:

1.1.1.225

BRENDA, the Enzyme Database:

1.1.1.225

CAS:	102484-73-1

DBGET integrated database retrieval system