| Entry |
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| Name |
salutaridine reductase (NADPH)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
salutaridinol:NADP+ 7-oxidoreductase
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| Reaction(IUBMB) |
salutaridinol + NADP+ = salutaridine + NADPH + H+ [RN: R04697]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Catalyses the reversible reduction of salutaridine to salutaridinol, which is a direct precursor of morphinan alkaloids in the poppy plant.
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| History |
EC 1.1.1.248 created 1999, modified 2001
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| Pathway |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K13392 | salutaridine reductase (NADPH) |
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| Genes |
| PSOM: | 113322262 113340174 |
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| Reference |
1 |
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| Authors |
Gerady, R. and Zenk, M.H. |
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| Title |
Purification and characterization of salutaridine:NADPH 7-oxidoreductase from Papaver somniferum. |
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| Journal |
Phytochemistry 34:125-132 (1993) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.248 |
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