KEGG ENZYME: 1.1.1.251

ENZYME: 1.1.1.251

Entry

EC 1.1.1.251                Enzyme

Name

galactitol-1-phosphate 5-dehydrogenase;
gatD (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

galactitol-1-phosphate:NAD+ oxidoreductase

Reaction(IUBMB)

galactitol 1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+ [RN:R05571]

Reaction(KEGG)

R05571

Substrate

galactitol 1-phosphate [CPD:C06311];
NAD+ [CPD:C00003]

Product

D-tagatose 6-phosphate [CPD:C01097];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme from the bacterium Escherichia coli is involved in a galactitol degradation pathway. It contains two zinc atoms per subunit.

History

EC 1.1.1.251 created 1999

Pathway

ec00052

Galactose metabolism

ec01100

Metabolic pathways

Orthology

K00094

galactitol-1-phosphate 5-dehydrogenase

Genes

ECO:	b2091(gatD)

ECJ:	JW2075(gatD)

ECD:	ECDH10B_2244(gatD)

EBW:	BWG_1877(gatD)

ECOC:

C3026_11740

ECE:	Z3254(gatD)

ECS:	ECs_2894(gatD)

ECF:	ECH74115_3070(gatD)

ETW:	ECSP_2886(gatD)

ELX:	CDCO157_2671

EOI:	ECO111_2807(gatD)

EOH:	ECO103_2565(gatD)

ECOO:

ECRM13514_2806(gatD)

ECOH:

ECRM13516_2720(gatD)

ESL:

O3K_08995

ESO:

O3O_16625

ESM:

O3M_08960

ECK:	EC55989_2345(gatD)

ECG:	E2348C_2236(gatD)

EOK:	G2583_2623(gatD)

ELR:	ECO55CA74_12625

ECW:	EcE24377A_2379(gatD)

ECP:

ECP_2129

ENA:	ECNA114_2182(gatD)

ECOS:

EC958_2425(gatD)

ECV:	APECO1_4454(gatD)

ECOA:

APECO78_14165

ECX:	EcHS_A2227(gatD)

ECM:	EcSMS35_0973(gatD)

ECY:

ECSE_2360

ECR:	ECIAI1_2165(gatD)

EUM:	ECUMN_2423(gatD)

ECT:	ECIAI39_0926(gatD)

EOC:	CE10_2405(gatD)

EBR:	ECB_02017(gatD)

ECOB:

C3029_14605

EBL:	ECD_02017(gatD)

EBE:	B21_01983(gatD)

EBD:

ECBD_1566

ECI:	UTI89_C2364(gatD)

EIH:	ECOK1_2320

ECZ:	ECS88_2233(gatD)

ECC:	c2616(gatD)

ELO:	EC042_2323(gatD)

ELN:	NRG857_10615

ESE:

ECSF_1973

ECL:	EcolC_1556

EKO:	EKO11_1663

EKF:	KO11_12165(gatD)

EAB:	ECABU_c24210(gatD)

EDH:	EcDH1_1567

EDJ:	ECDH1ME8569_2025(gatD)

ELU:	UM146_06335

ELW:	ECW_m2292(gatD)

ELL:	WFL_11215(gatD)

ELC:	i14_2417(gatD)

ELD:	i02_2417(gatD)

ELP:	P12B_c2188(gatD)

ELF:	LF82_0811(gatD)

ECOL:

LY180_10935

ECOI:

ECOPMV1_02249(tdh_3)

ECOJ:

P423_11805

ESZ:	FEM44_00670(gatD)

ERUY:

OSH18_20820(gatD)

STY:	STY3444(gatD)

STT:	t3181(gatD)

SEX:	STBHUCCB_33650

SENT:

TY21A_16125

STM:

STM3261

SEO:	STM14_3943

SEV:	STMMW_32611

SEY:	SL1344_3234(gatD)

SEM:	STMDT12_C33180

SEJ:	STMUK_3245

SEB:	STM474_3418

SEF:	UMN798_3549(gatD)

SETU:

STU288_16510

SETC:

CFSAN001921_00705

SENR:

STMDT2_31541(gatD)

SEND:

DT104_32561(gatD)

SENI:

CY43_16985

SEEN:

SE451236_22400

SPT:	SPA3130(gatD)

SEK:

SSPA2922

SPQ:	SPAB_04071

SEI:	SPC_3332(gadD)

SEC:	SCH_3202(gadD)

SEH:	SeHA_C3556

SHB:

SU5_03749

SENH:

CFSAN002069_15860

SEEH:

SEEH1578_02425

SEE:	SNSL254_A3519

SENN:

SN31241_43860

SEW:	SeSA_A3450

SEA:	SeAg_B3448

SENS:

Q786_15885

SED:

SeD_A3616

SEG:

SG3152

SEL:

SPUL_3270

SEGA:

SPUCDC_3256

SET:

SEN3096

SENA:

AU38_15765

SENO:

AU37_15965

SENV:

AU39_15960

SENQ:

AU40_17770

SENL:

IY59_16365

SENJ:

CFSAN001992_17230

SEEC:

CFSAN002050_23270

SEEB:

SEEB0189_003565

SEEP:

I137_15590

SENB:

BN855_33420

SENE:

IA1_15780

SENC:

SEET0819_23285

SBG:	SBG_2892(gatD)

SBZ:

A464_3342

SBV:	N643_14245

SALZ:

EOS98_02975

SFL:	SF2151(gatD)

SFX:	S2277(gatD)

SFE:	SFxv_2380(gatD)

SFN:

SFy_3039

SFS:

SFyv_3112

SFT:	NCTC1_02367(gatD)

SSN:	SSON_2138(gatD)

SBO:	SBO_0912(gatD)

SBC:	SbBS512_E1147(gatD)

SDY:	SDY_2263(gatD)

SDZ:	Asd1617_03056

SHQ:	A0259_14270

ECLZ:

LI64_18870

EKB:	BFV64_20615

ENO:	ECENHK_19445

ECLS:

LI67_021190

LNI:	CWR52_15430

END:	A4308_04110

CUI:	AFK65_02310

CMW:	AFK63_16220

CTU:	CTU_04350(gatD)

KPN:	KPN_03551(gatD)

KPU:	KP1_4855(gatD)

KPM:	KPHS_46880

KPP:

A79E_0562

KPH:	KPNIH24_05460

KPV:	KPNIH29_23290

KPW:	KPNIH30_23615

KPG:	KPNIH32_24495

KPC:	KPNIH10_23340

KPQ:	KPR0928_22860

KPJ:

N559_0616

KPA:	KPNJ1_00601

KPS:	KPNJ2_00639

KPB:	FH42_14055

KPNE:

KU54_002970

KPNU:

LI86_02975

KVA:

Kvar_0546

KVD:	KR75_05285

KVQ:	SP68_11905

KOX:

KOX_03535

KOE:

A225_5157

KOY:	J415_06230

KQU:	AVR78_01605

KQV:	B8P98_03030

KLL:	BJF97_25710

KLW:	DA718_03460

KAR:	LGL98_02885(gatD)

KGR:	JJJ10_03085(gatD)

KPAS:

LUW96_03435(gatD)

KLM:	BWI76_24895

CWE:	CO701_00800

CPOT:

FOB25_14240(gatD)

CFQ:	C2U38_22630

CSED:

JY391_03115(gatD)

CIF:	AL515_20555

CPAR:

CUC49_16295

KOR:	AWR26_02850(gatD)

KRD:	A3780_21870

KCO:	BWI95_07120

KOT:	EH164_02685

KIE:	NCTC12125_04489(gutB_2)

LEH:	C3F35_14820

LAZ:	A8A57_18540

BFT:	MNO13_21605(gatD)

AHN:	NCTC12129_03669(gatD_2)

ASUB:

NLZ15_06285

METY:

MRY16398_06260

PSGC:

G163CM_41690(gatD)

SCOL:

KFZ77_08700(gatD)

SUPE:

P0H77_19900(gatD)

EBB:

F652_2337

PSTS:

E05_50960

SFW:	WN53_06580

SFG:	AV650_04325

RAH:	Rahaq_3466

RACE:

JHW33_11550

RAQ:	Rahaq2_3542

RAA:

Q7S_17450

ROX:	BV494_12380

RVC:	J9880_03040(gatD)

RBON:

QNM34_17795(gatD)

RIU:	I2123_19230(gatD)

CARU:

P0E69_14650(gatD)

NIG:	C1N62_12290

SLIG:

GTU79_05625

ERP:	LJN55_03735

PHEI:

NCTC12003_03174(tdh_2)

HSO:	HS_1141(gatD)

HSM:

HSM_1035

AAO:	ANH9381_1628

AAN:

D7S_02347

AAH:	CF65_02047

AACN:

AANUM_1585

AACT:

ACT75_10800

GSS:	NYR30_12080

GAP:	GAPWK_0183

PMAS:

NCF86_15675(gatD)

OCK:	EXM22_18110

FUL:	C4N20_03410

STR:	Sterm_3384

» show all

Reference

1 [PMID:13331868]

Authors

WOLFF JB, KAPLAN NO

Title

Hexitol metabolism in Escherichia coli.

Journal

J Bacteriol 71:557-64 (1956)
DOI:10.1128/JB.71.5.557-564.1956

Reference

2 [PMID:7772602]

Authors

Nobelmann B, Lengeler JW

Title

Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli.

Journal

Biochim Biophys Acta 1262:69-72 (1995)
DOI:10.1016/0167-4781(95)00053-J

Sequence

[eco:b2091]

Reference

3 [PMID:26143925]

Authors

Benavente R, Esteban-Torres M, Kohring GW, Cortes-Cabrera A, Sanchez-Murcia PA, Gago F, Acebron I, de las Rivas B, Munoz R, Mancheno JM

Title

Enantioselective oxidation of galactitol 1-phosphate by galactitol-1-phosphate 5-dehydrogenase from Escherichia coli.

Journal

Acta Crystallogr D Biol Crystallogr 71:1540-54 (2015)
DOI:10.1107/S1399004715009281

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.251

IUBMB Enzyme Nomenclature:

1.1.1.251

ExPASy - ENZYME nomenclature database:

1.1.1.251

BRENDA, the Enzyme Database:

1.1.1.251

CAS:	60120-43-6

DBGET integrated database retrieval system