KEGG ENZYME: 1.1.1.255

ENZYME: 1.1.1.255

Entry

EC 1.1.1.255                Enzyme

Name

mannitol dehydrogenase;
MTD;
NAD+-dependent mannitol dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

mannitol:NAD+ 1-oxidoreductase

Reaction(IUBMB)

D-mannitol + NAD+ = D-mannose + NADH + H+ [RN:R07135]

Reaction(KEGG)

R07135

Substrate

D-mannitol [CPD:C00392];
NAD+ [CPD:C00003]

Product

D-mannose [CPD:C00159];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme from Apium graveolens (celery) oxidizes alditols with a minimum requirement of 2R chirality at the carbon adjacent to the primary carbon undergoing the oxidation. The enzyme is specific for NAD+ and does not use NADP+.

History

EC 1.1.1.255 created 2000

Orthology

K00095

mannitol dehydrogenase

Genes

ECAD:

122603035 122603475

DCR:

108210906

Reference

1 [PMID:1416989]

Authors

Stoop JM, Pharr DM.

Title

Partial purification and characterization of mannitol: mannose 1-oxidoreductase from celeriac (Apium graveolens var. rapaceum) roots.

Journal

Arch Biochem Biophys 298:612-9 (1992)
DOI:10.1016/0003-9861(92)90456-7

Reference

2 [PMID:7630943]

Authors

Stoop JM, Williamson JD, Conkling MA, Pharr DM.

Title

Purification of NAD-dependent mannitol dehydrogenase from celery suspension cultures.

Journal

Plant Physiol 108:1219-25 (1995)
DOI:10.1104/pp.108.3.1219

Reference

3 [PMID:7638158]

Authors

Williamson JD, Stoop JM, Massel MO, Conkling MA, Pharr DM

Title

Sequence analysis of a mannitol dehydrogenase cDNA from plants reveals a function for the pathogenesis-related protein ELI3.

Journal

Proc Natl Acad Sci U S A 92:7148-52 (1995)
DOI:10.1073/pnas.92.16.7148

Sequence

[ag:AAC15467]

Reference

Authors

Stoop, J.M.H., Chilton, W.S. and Pharr, D.M.

Title

Substrate specificity of the NAD-dependent mannitol dehydrogenase from celery.

Journal

Phytochemistry 43:1145-1150 (1996)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.255

IUBMB Enzyme Nomenclature:

1.1.1.255

ExPASy - ENZYME nomenclature database:

1.1.1.255

BRENDA, the Enzyme Database:

1.1.1.255

CAS:	144941-29-7

DBGET integrated database retrieval system