ENZYME: 1.1.1.297 Help
Entry
Name
limonene-1,2-diol dehydrogenase;
NAD+-dependent limonene-1,2-diol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
menth-8-ene-1,2-diol:NAD+ oxidoreductase
Reaction(IUBMB)
menth-8-ene-1,2-diol + NAD+ = 1-hydroxymenth-8-en-2-one + NADH + H+ (general reaction) [RN:
R08919 ];
(1) (1S,2S,4R)-menth-8-ene-1,2-diol + NAD+ = (1S,4R)-1-hydroxymenth-8-en-2-one + NADH + H+ [RN:
R06399 ];
(2) (1R,2R,4S)-menth-8-ene-1,2-diol + NAD+ = (1R,4S)-1-hydroxymenth-8-en-2-one + NADH + H+ [RN:
R09388 ]
Reaction(KEGG)
Substrate
menth-8-ene-1,2-diol [CPD:
C18020 ];
NAD+ [CPD:
C00003 ];
(1S,2S,4R)-menth-8-ene-1,2-diol [CPD:
C07276 ];
(1R,2R,4S)-menth-8-ene-1,2-diol [CPD:
C19082 ]
Product
1-hydroxymenth-8-en-2-one [CPD:
C18019 ];
NADH [CPD:
C00004 ];
H+ [CPD:
C00080 ];
(1S,4R)-1-hydroxymenth-8-en-2-one [CPD:
C11937 ];
(1R,4S)-1-hydroxymenth-8-en-2-one
Comment
While the enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 can use both (1S,2S,4R)- and (1R,2R,4S)-menth-8-ene-1,2-diol as substrate, activity is higher with (1S,2S,4R)-menth-8-ene-1,2-diol as substrate.
History
EC 1.1.1.297 created 2008
Pathway
ec01120 Microbial metabolism in diverse environments
Reference
Authors
van der Werf MJ, Swarts HJ, de Bont JA
Title
Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.297