KEGG   ENZYME: 1.1.1.298
Entry
EC 1.1.1.298                Enzyme                                 
Name
3-hydroxypropionate dehydrogenase (NADP+);
3-hydroxypropanoate dehydrogenase (NADP+);
3-hydroxypropionate:NADP+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3-hydroxypropanoate:NADP+ oxidoreductase
Reaction(IUBMB)
3-hydroxypropanoate + NADP+ = malonate semialdehyde + NADPH + H+ [RN:R09289]
Reaction(KEGG)
R09289
Substrate
3-hydroxypropanoate [CPD:C01013];
NADP+ [CPD:C00006]
Product
malonate semialdehyde [CPD:C00222];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Catalyses the reduction of malonate semialdehyde to 3-hydroxypropanoate, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively [1,2]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC 1.2.1.75 [3]. Different from EC 1.1.1.59 [3-hydroxypropionate dehydrogenase (NAD+)] by cofactor preference.
History
EC 1.1.1.298 created 2009
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14468  malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+)
K15039  3-hydroxypropionate dehydrogenase (NADP+)
Genes
PAQME0F26_07700
SRADLLW23_04765
BLASBSY18_2663
BFWB5J99_04270
PALGHFP57_16700
SANDH3309_14805
POQKZX46_11630
PMEAKTC28_17245
ELQGa0102493_111748
ERKCD351_07810
PNSA9D12_09055
PORLBG023_111319
PHZCHX26_07200
POTE2E27_15410
RRSRoseRS_3201
RCARcas_2929
CAUCaur_2614
CHLChy400_2826
CAGCagg_1256
CTMCabther_B0159
CVLJ8C06_14250
CHLOJ8C02_13405
GGRHKW67_05060
STOSTK_15070
SOHD1869_08465
SSOSSO0647(hdb-1)
SOLSsol_1706
SSOASULA_1734
SSOLSULB_1735
SSOFSULC_1733
SSHIJ5U23_02760
SCASSACC_03350
SAISaci_1623
SACNSacN8_07880
SACRSacRon12I_07890
SACSSUSAZ_07690
SISLS215_1598
SIAM1425_1490
SIMM1627_1605
SIDM164_1487
SIYYG5714_1494
SINYN1551_1342
SIILD85_1697
SIHSiH_1456
SIRSiRe_1366
SICSiL_1369
SULABFU36_02810
SULEGFS03_08515
SULOGFS33_00290
SULLEWF20_09635
MSEMsed_1993
MEMJMJ1HA_2261
MCNMcup_0293
MHKDFR87_08540
MPRUDFR88_08210
MTENGWK48_03785
MJNMjAS7_0293
AHOAhos_1103
AMANB6F84_09585
ABRIDFR85_09210
ASULDFR86_08270
AAMBD1866_00385
ACIHHS5_24980
SAZOD1868_05505
CSTYKN1_27070
STEPIC006_1364
SMETRQ359_000547
 » show all
Reference
1  [PMID:8354269]
  Authors
Strauss G, Fuchs G
  Title
Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle.
  Journal
Eur J Biochem 215:633-43 (1993)
DOI:10.1111/j.1432-1033.1993.tb18074.x
Reference
2  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science 318:1782-6 (2007)
DOI:10.1126/science.1149976
Reference
3  [PMID:11948153]
  Authors
Hugler M, Menendez C, Schagger H, Fuchs G
  Title
Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:2404-10 (2002)
DOI:10.1128/JB.184.9.2404-2410.2002
  Sequence
[cau:Caur_2614]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.298
IUBMB Enzyme Nomenclature: 1.1.1.298
ExPASy - ENZYME nomenclature database: 1.1.1.298
BRENDA, the Enzyme Database: 1.1.1.298

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