Entry
Name
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase;
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase;
MjaRED;
MJ0671 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one:NAD(P)+ oxidoreductase
Reaction(IUBMB)
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + NAD(P)+ = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + NAD(P)H + H+ [RN:
R09375 R09376 ]
Reaction(KEGG)
Substrate
2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one [CPD:
C18910 ];
NAD+ [CPD:
C00003 ];
NADP+ [CPD:
C00006 ]
Product
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:
C01304 ];
NADH [CPD:
C00004 ];
NADPH [CPD:
C00005 ];
H+ [CPD:
C00080 ]
Comment
The reaction proceeds in the opposite direction. A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant. Differs from EC
1.1.1.193 [5-amino-6-(5-phosphoribosylamino)uracil reductase] since it does not catalyse the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate [1].
History
EC 1.1.1.302 created 2010, modified 2011
Pathway
Orthology
K14654 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
Genes
NCS : NCAS_0I02380(NCAS0I02380)
NDI : NDAI_0A06950(NDAI0A06950)
TPF : TPHA_0A00760(TPHA0A00760)
TBL : TBLA_0F01170(TBLA0F01170)
TDL : TDEL_0D05100(TDEL0D05100)
KAF : KAFR_0G01390(KAFR0G01390)
KNG : KNAG_0K02030(KNAG0K02030)
SPAA : SPAPADRAFT_71929(RIB7)
CAL : CAALFM_C112810WA(CaO19.6341)
NTE : NEUTE1DRAFT60176(NEUTE1DRAFT_60176)
BFU : BCIN_09g06970(Bcrib7)
AFM : AFUA_3G00360 AFUA_4G04730
ACT : ACLA_053610 ACLA_064060
NFI : NFIA_000890 NFIA_028600
AOR : AO090038000135 AO090206000013
ANG : An01g01960 An14g00090
AFV : AFLA_012405 AFLA_013012
ALUC : AKAW2_20386S(RIB7_1) AKAW2_40698A(RIB7_2)
ACHE : ACHE_11425A(RIB7_1) ACHE_31026A(RIB7_2)
APUU : APUU_10865S(RIB7_1) APUU_80640A(RIB7_2)
PCS : N7525_002301 N7525_003594
PDP : PDIP_04060 PDIP_14820
CCAC : CcaHIS019_0107940(CcaverHIS019_0107940)
ABP : AGABI1DRAFT67276(AGABI1DRAFT_67276)
ABV : AGABI2DRAFT213834(AGABI2DRAFT_213834)
SCM : SCHCO_02644532(SCHCODRAFT_02644532)
GTT : GUITHDRAFT_114190 GUITHDRAFT_131505
TWG : Thiowin_01934(ribD_1)
PMAU : CP157_01059(ribD_1)
TSU : Tresu_0724 Tresu_0791
MEL : Metbo_0239 Metbo_2125
MEW : MSWAN_0486 MSWAN_2212
METH : MBMB1_0612 MBMB1_1846
MFC : BRM9_1623(ribD1) BRM9_2175(ribD2)
MFI : DSM1535_1115 DSM1535_2318
MCUB : MCBB_0498 MCBB_2139
MSUB : BK009_01155 BK009_08405
METN : BK008_04065 BK008_08845
METT : CIT01_04545 CIT01_09480
METO : CIT02_03870 CIT02_08340
MFEG : GCM10025860_04780 GCM10025860_16220
MBA : Mbar_A0489 Mbar_A1048
MBY : MSBRM_3060 MSBRM_3306
MBW : MSBRW_0514 MSBRW_3673
MBAR : MSBR2_3018 MSBR2_3261
MBAK : MSBR3_3015 MSBR3_3257
MAC : MA_4092(ribD) MA_4367(ribD)
MMJ : MSMAS_0241 MSMAS_0480
MMAC : MSMAC_0248 MSMAC_0498
MVC : MSVAZ_0230 MSVAZ_3133
MEK : MSKOL_0223 MSKOL_3121
MLS : MSLAZ_2682 MSLAZ_2978
METM : MSMTP_0280 MSMTP_0527
MEF : MSWH1_0556 MSWH1_2985
MEQ : MSWHS_0571 MSWHS_2005
MSJ : MSSAC_3965 MSSAC_4059
MSZ : MSSIH_3491 MSSIH_3595
MSW : MSSIT_3554 MSSIT_3648
MTHR : MSTHT_1446 MSTHT_1760
MTHE : MSTHC_1531 MSTHC_1843
MHOR : MSHOH_0311 MSHOH_0574
MFZ : AOB57_006315 AOB57_007985
MMET : MCMEM_0497 MCMEM_1294
MELO : J7W08_00505 J7W08_05105
MEHF : MmiHf6_06000(ribD2)
MEES : MmiEs2_04040(ribD2)
MCJ : MCON_0173(ribD) MCON_0968
MRTJ : KHC33_03740 KHC33_09580
MEM : Memar_0446 Memar_1398 Memar_2026
MBG : BN140_0241(ribD) BN140_1191
MEMA : MMAB1_0301 MMAB1_1511(ribD)
MCHK : MchiMG62_05740 MchiMG62_15920(ribD2) MchiMG62_23370
MSUM : OH143_01210 OH143_04400 OH143_08930
MRC : R6Y96_00465 R6Y96_05740
MPI : Mpet_0779 Mpet_1801 Mpet_2483
MEND : L6E24_01355 L6E24_10935
MEFW : F1737_03710 F1737_07155 F1737_09385
MAQE : RJ40_03555 RJ40_04390 RJ40_04445
MFK : E2N92_03610 E2N92_04590 E2N92_04650
MOU : OU421_10065 OU421_12705
MESB : L1S32_01265 L1S32_04465 L1S32_11820
MANQ : L1994_04135 L1994_07825
MFO : Metfor_0570 Metfor_1256 Metfor_2280
MELU : MTLP_05680(ribD2) MTLP_12030
MEAM : MU439_00250 MU439_04645
LOKI : Lokiarch_12300 Lokiarch_13540
» show all
Taxonomy
Reference
Authors
Graupner M, Xu H, White RH
Title
The pyrimidine nucleotide reductase step in riboflavin and F(420) biosynthesis in archaea proceeds by the eukaryotic route to riboflavin.
Journal
Sequence
Reference
Authors
Chatwell L, Krojer T, Fidler A, Romisch W, Eisenreich W, Bacher A, Huber R, Fischer M
Title
Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.302