KEGG ENZYME: 1.1.1.310

ENZYME: 1.1.1.310

Entry

EC 1.1.1.310                Enzyme

Name

(S)-sulfolactate dehydrogenase;
(2S)-3-sulfolactate dehydrogenase;
SlcC

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(2S)-sulfolactate:NAD+ oxidoreductase

Reaction(IUBMB)

(2S)-3-sulfolactate + NAD+ = 3-sulfopyruvate + NADH + H+ [RN:R05693]

Reaction(KEGG)

R05693

Substrate

(2S)-3-sulfolactate [CPD:C11499];
NAD+ [CPD:C00003]

Product

3-sulfopyruvate [CPD:C05528];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

This enzyme, isolated from the bacterium Chromohalobacter salexigens DSM 3043, acts only on the (S)-enantiomer of 3-sulfolactate. Combined with EC 1.1.1.338, (2R)-3-sulfolactate dehydrogenase (NADP+), it provides a racemase system that converts (2S)-3-sulfolactate to (2R)-3-sulfolactate, which is degraded further by EC 4.4.1.24, (2R)-sulfolactate sulfo-lyase.
The enzyme is specific for NAD+.

History

EC 1.1.1.310 created 2011, modified 2013

Pathway

ec00270

Cysteine and methionine metabolism

ec01100

Metabolic pathways

Orthology

K16843

(S)-sulfolactate dehydrogenase

Genes

SHAI:

LMH63_10850

APRS:

BI364_08725

CSA:

Csal_1770

HBE:	BEI_0838(slcC)

SVA:

SVA_1860

RPJ:	N234_02635

CUH:	BJN34_26760

REU:	Reut_B3530

CTI:	RALTA_B0841(serA2)

CBW:	RR42_m0458

CGD:	CR3_0183(slcC)

COX:	E0W60_13290

CCAX:

KZ686_04915

CNAN:

A2G96_27605

BXE:

Bxe_B1896

BXB:

DR64_7205

PGIS:

I6I06_21470

PACS:

FAZ98_25215

PANI:

DCO16_04965

PWU:	A8O14_02435

PTX:	ABW99_10895

CABA:

SBC2_17580(slcC)

TVL:	FAZ95_15405

BPT:	Bpet0409(serA2)

BBRO:

BAU06_18080

BFZ:	BAU07_08200

BOH:	AKI39_17275

BGM:	CAL15_02265

BGV:	CAL12_19020

AXY:	AXYL_00471(serA1)

AXO:	NH44784_017141

AXN:	AX27061_0477

AXX:	ERS451415_00471(serA_1)

ADT:	APT56_02490

AIS:	BUW96_28015

ASW:	CVS48_11545

ACHR:

C2U31_07140

ADY:	HLG70_19610

ACHO:

H4P35_02080

AMUI:

PE062_26090

APES:

FOC84_10145

AAEG:

RA224_02315

AKA:	TKWG_23305

AMIM:

MIM_c37610(serA2)

PARK:

LSG25_12710

VEI:

Veis_0891

VAP:	Vapar_3820

VPD:	VAPA_1c39330

CKE:	B5M06_01520

ATER:

MW290_18645

HAR:

HEAR3340

ACTB:

RHM62_14995

URU:	DSM104443_02184(slcC)

UPL:	DSM104440_02014(slcC)

ACOM:

CEW83_08350

BEBA:

BWI17_15940

MESO:

BSQ44_12890

CHEA:

PVE73_02265

NIY:	FQ775_22315

KMN:	HW532_06430

EMX:	FKV68_25170

KAI:

K32_36520

OCA:

OCAR_7552

OCG:	OCA5_c05880(serA1)

OCO:	OCA4_c05870(serA1)

PCAX:

AFIC_002274

BOP:	AXW83_05585

BOS:	BSY19_2611

BVV:	BHK69_18040

BOI:	BLM15_06700

BOF:	FQV39_07605

BVES:

QO058_00755

MRD:	Mrad2831_4214 Mrad2831_5977

MET:

M446_6454

MOR:

MOC_4868

MPHY:

MCBMB27_03728

METX:

A3862_10280

METI:

DK427_02130

MMES:

MMSR116_04765

MTAD:

M6G65_25990

RVA:

Rvan_3575

RLAC:

QMO75_13560

FIL:	BN1229_v1_1881(slcC)

FIY:	BN1229_v1_1884(slcC)

CMET:

K6K41_04850

AUB:	LXB15_20875

LABP:

FJ695_09905

PSTG:

E8M01_21825

PAQT:

E8L99_13585

DSH:	Dshi_1001(serA2)

TPRO:

Ga0080559_TMP3623

PSEW:

JHW44_18570

PAEX:

JHW48_16240

PFEO:

E3U26_14700

RSU:

NHU_04238

RHM:	B5V46_17730

RBG:	BG454_02465

POZ:	I0K15_15000

CMAG:

CBW24_05860

ACIM:

GT370_19975

AZL:	AZL_004920(serA)

ALI:	AZOLI_0344

ATI:	AL072_01935

AHU:	A6A40_01385

AZM:	DM194_01050

AZS:	E6C72_06400

NCB:	C0V82_01490

SKT:	IGS68_14035

SMUC:

JL100_013875

SROE:

JL101_013570

VSU:	P3M64_05645

ELIO:

KO353_01270

TMUR:

JBF11_07060

DMP:

FAK_06040

BACA:

FAY30_23715

BON:	A361_10255

HMN:	HM131_18630

LAO:	AOX59_17370

AQT:	FN924_15335

SCIA:

HUG15_20685

NMK:	CHR53_24465

PSAB:

PSAB_19150

PBJ:	VN24_05940

AFX:	JZ786_10480 JZ786_13645

ACUR:

JZ785_23000

ADAU:

NZD86_03685

EFF:	skT53_05870

NTR:	B0W44_06085

DRU:	Desru_0084 Desru_1692

DKU:	Desku_0182

TMR:

Tmar_1044

THEF:

E1B22_08885

THEP:

DYI95_005190

SAY:	TPY_1961(serA) TPY_2384(serA)

SAP:	Sulac_2157 Sulac_3141

STHR:

BXT84_07540

STED:

SPTER_32830(slcC)

RHA:	RHA1_ro08844(serA3)

RKO:	JWS14_47745

MPH:

MLP_21630

AMAZ:

LUW76_22385

ACTQ:

OG417_30925

PLAN:

A1s21148_06280

PVN:	A7sIIA15_00850

MRB:

Mrub_2461

MRE:	K649_10225

MTAI:

Mtai_v1c20760

MSV:	Mesil_1013

GMR:	GmarT_17400(serA_3)

GIM:	F1728_06080

GPN:	Pan110_17230(serA_3)

» show all

Reference

1 [PMID:20007648]

Authors

Denger K, Cook AM

Title

Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.

Journal

Microbiology 156:967-74 (2010)
DOI:10.1099/mic.0.034736-0

Sequence

[csa:Csal_1770]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.310

IUBMB Enzyme Nomenclature:

1.1.1.310

ExPASy - ENZYME nomenclature database:

1.1.1.310

BRENDA, the Enzyme Database:

1.1.1.310

DBGET integrated database retrieval system