KEGG ENZYME: 1.1.1.315

ENZYME: 1.1.1.315

Entry

EC 1.1.1.315                Enzyme

Name

11-cis-retinol dehydrogenase;
RDH5 (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

11-cis-retinol:NAD+ oxidoreductase

Reaction(IUBMB)

11-cis-retinol---[retinal-binding-protein] + NAD+ = 11-cis-retinal---[retinol-binding-protein] + NADH + H+

Reaction(KEGG)

(other) R03048 R08382

Substrate

11-cis-retinol---[retinal-binding-protein];
NAD+ [CPD:C00003]

Product

11-cis-retinal---[retinol-binding-protein];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

This enzyme, abundant in the retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal [1] while the substrate is bound to the retinal-binding protein [4]. This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin. The enzyme can also accept other cis forms of retinol [2].

History

EC 1.1.1.315 created 2011

Orthology

K00061

11-cis-retinol dehydrogenase

Genes

HSA:	5959(RDH5)

PTR:	467029(RDH5)

PPS:	100988391(RDH5)

GGO:	101125878(RDH5)

PON:	100437933(RDH5)

NLE:	100598708(RDH5)

HMH:	116480951(RDH5)

MCC:	709644(RDH5)

MCF:	107126391(RDH5)

MTHB:

126931137

MNI:	105474180(RDH5)

CSAB:

103238482(RDH5)

CATY:

105587331(RDH5)

PANU:

101020375(RDH5)

TGE:	112634360(RDH5)

MLEU:

105532012(RDH5)

RRO:	104673711(RDH5)

RBB:	108516026(RDH5)

TFN:	117089975(RDH5)

PTEH:

111541884(RDH5)

CANG:

105500576(RDH5)

CJC:	100402026(RDH5)

SBQ:	101051979(RDH5)

CIMI:

108296819(RDH5)

CSYR:

103266789(RDH5)

MMUR:

109729192(RDH5)

LCAT:

123639691(RDH5)

PCOQ:

105817191(RDH5)

OGA:	100962477(RDH5)

MMU:	19682(Rdh5)

MCAL:

110303548(Rdh5)

MPAH:

110327089(Rdh5)

RNO:	366791(Rdh5)

MCOC:

116075885(Rdh5)

ANU:	117696406(Rdh5)

MUN:	110563162(Rdh5)

CGE:	100772460(Rdh5)

MAUA:

101842006(Rdh5)

PROB:

127215605(Rdh5)

PLEU:

114681765(Rdh5)

MORG:

121462246(Rdh5)

MFOT:

126492053

AAMP:

119803379(Rdh5)

NGI:	103738827(Rdh5)

HGL:	101701578(Rdh5)

CPOC:

100716482(Rdh5)

CCAN:

109696229(Rdh5)

DORD:

105990761(Rdh5)

DSP:	122124150(Rdh5)

PLOP:

125363298(Rdh5)

NCAR:

124983578

MMMA:

107140207(Rdh5)

OCU:	100346443 127487414

OPI:	101534881(RDH5)

TUP:	102492697(RDH5)

GVR:	103599051(RDH5)

CFA:	481098(RDH5)

CLUD:

112678051(RDH5)

VVP:	112922414(RDH5)

VLG:	121491616(RDH5)

NPO:	129511946(RDH5)

AML:	100477613(RDH5)

UMR:	103682388(RDH5)

UAH:	113256460(RDH5)

UAR:	123787282(RDH5)

ELK:

111160231

LLV:

125107375

MPUF:

101694013(RDH5)

MNP:	132019768(RDH5)

MLK:	131838633(RDH5)

NVS:	122891622(RDH5)

ORO:	101378842(RDH5)

EJU:	114215022(RDH5)

ZCA:	113922945(RDH5)

MLX:	118008746(RDH5)

NSU:	110577748(RDH5)

LWW:	102728379(RDH5)

FCA:	101090450(RDH5)

PYU:	121040964(RDH5)

PCOO:

112863684(RDH5)

PBG:	122473719(RDH5)

PVIV:

125170188(RDH5)

LRUF:

124501702

PTG:	102955802(RDH5)

PPAD:

109270294(RDH5)

PUC:

125919185

AJU:

106986902

HHV:	120219944(RDH5)

BTA:	281448(RDH5)

BOM:	102281461(RDH5)

BIU:	109559397(RDH5)

BBUB:

102405059(RDH5)

BBIS:

104988039(RDH5)

CHX:	102179453(RDH5)

OAS:	101115199(RDH5)

BTAX:

128047712(RDH5)

ODA:	120857407(RDH5)

CCAD:

122427804(RDH5)

MBEZ:

129535734(RDH5)

SSC:	100517586(RDH5)

CFR:	102522460(RDH5)

CBAI:

105075923(RDH5)

CDK:	105086399(RDH5)

VPC:	102536073(RDH5)

BACU:

103013640(RDH5)

BMUS:

118902874(RDH5)

LVE:	103070515(RDH5)

OOR:	101272361(RDH5)

DLE:	111173906(RDH5)

PCAD:

102981003(RDH5)

PSIU:

116761093(RDH5)

NASI:

112393963(RDH5)

ECB:	100051379(RDH5)

EPZ:	103560206(RDH5)

EAI:	106841311(RDH5)

MYB:	102250054(RDH5)

MYD:	102752637(RDH5)

MMYO:

118650216(RDH5)

MLF:	102418468(RDH5)

PKL:	118730397(RDH5)

EFUS:

103292395(RDH5)

MNA:	107538219(RDH5)

DRO:	112319078(RDH5)

SHON:

118975846(RDH5)

AJM:	119048530(RDH5)

PDIC:

118496626(RDH5)

PHAS:

123812926(RDH5)

MMF:	118624197(RDH5)

PPAM:

129084787(RDH5)

HAI:	109396898(RDH5)

RFQ:	117029459(RDH5)

PALE:

102890960(RDH5)

PGIG:

120604875(RDH5)

PVP:	105302612(RDH5)

RAY:	107521261(RDH5)

MJV:	108395935(RDH5)

TOD:	119248026(RDH5)

SARA:

101546945(RDH5)

LAV:	100665758(RDH5)

TMU:

101359207

ETF:	101640458(RDH5)

DNM:	101444166(RDH5)

GAS:	123249031(RDH5)

SHR:	100926680(RDH5)

AFZ:

127563998

PCW:	110210897(RDH5)

OAA:	100077776(RDH5)

GGA:	395452(RDH5)

PCOC:

116235212(RDH5)

MGP:

100551395

CJO:	107325819(RDH5)

TPAI:

128090510(RDH5)

LMUT:

125685424(RDH5)

NMEL:

110391116(RDH5)

CATA:

118261018(RDH5)

AFUL:

116500006(RDH5)

LSR:

110483543

PMOA:

120503923(RDH5)

OTC:	121338757(RDH5)

PRUF:

121352058

PHI:	102110114(RDH5)

ETL:	114070099(RDH5)

SVG:	106863807(RDH5)

HRT:	120764511(RDH5)

CLV:	102088293(RDH5)

TALA:

116961526(RDH5)

ACHC:

115350876(RDH5)

HLE:	104830291(RDH5)

AGEN:

126046456

GCL:

127028450

SHAB:

115618638(RDH5)

RTD:	128903176(RDH5)

NPD:	112954223(RDH5)

ASN:	102385802(RDH5)

AMJ:	102572099(RDH5)

PSS:	102452664(RDH5)

CMY:	119564299(RDH5)

CCAY:

125627463(RDH5)

DCC:	119845898(RDH5)

CPIC:

101937595(RDH5)

TST:	117888703(RDH5)

CABI:

116827762(RDH5)

MRV:	120391110(RDH5)

ACS:	100561257(rdh5)

ASAO:

132768239(RDH5)

PVT:	110073773(RDH5)

SUND:

121921108(RDH5)

PBI:	103065660(RDH5)

PMUR:

107294926(RDH5)

CTIG:

120306221(RDH5)

TSR:	106544310(RDH5)

PGUT:

117662852(RDH5)

APRI:

131191149(RDH5)

PTEX:

113443109(RDH5)

NSS:	113420730(RDH5)

VKO:	123033167(RDH5)

PMUA:

114587482(RDH5)

PRAF:

128407170(RDH5)

ZVI:	118079582(RDH5)

HCG:	128345546(RDH5)

GJA:	107121726(RDH5)

STOW:

125427669(RDH5)

EMC:	129346047(RDH5)

XLA:	444623(rdh5.L) 447549(rdh5.S)

XTR:	496830(rdh5)

NPR:	108796498(RDH5)

RTEM:

120929556(RDH5)

BBUF:

120993663(RDH5)

BGAR:

122931032(RDH5)

MUO:	115465921(RDH5)

GSH:	117358234(RDH5)

DRE:	556528(rdh5)

SRX:	107736472 107745400

SANH:

107653177

SGH:	107573570 107586996

CCAR:

109062934 109063464

CAUA:

113039486 113039514 113040775 113064698 113080109

CGIB:

127942941 127986955

PTET:

122327424(rdh5)

LROH:

127153976(rdh5)

OMC:	131531002(rdh5)

PPRM:

120492909(rdh5)

RKG:	130077279(rdh5)

MAMB:

125263575(rdh5)

CIDE:

127519800

MASI:

127437957 127439180

TROS:

130548747(rdh5)

TDW:	130430209 130430216

MANU:

129453787(rdh5)

IPU:

108281000

IFU:	128624776(rdh5)

PHYP:

113538008(rdh5)

SMEO:

124402340(rdh5)

TFD:	113639090(rdh5)

TVC:	132838326(rdh5)

AMEX:

103042897(rdh5)

CMAO:

118799677(rdh5)

EEE:

113580614

CHAR:

122131888(rdh5)

TRU:

101069778

TFS:	130524959(rdh5)

TNG:	GSTEN00037625G001

LCO:	104922032(rdh5)

NCC:

104964277

TBEN:

117489824(rdh5)

CGOB:

115007744(rdh5)

PGEO:

117446590(rdh5)

GACU:

117539526(rdh5)

EMAC:

134882704(rdh5)

ELY:	117256620(rdh5)

EFO:	125892935(rdh5)

PLEP:

121954371(rdh5)

SLUC:

116051415 116051418(rdh5)

ECRA:

117943470(rdh5)

ESP:	116687746(rdh5)

PFLV:

114554590

GAT:	120834586(rdh5)

PPUG:

119229689(rdh5)

AFB:	129106164(rdh5)

CLUM:

117730255(rdh5)

PSWI:

130207729(rdh5)

MSAM:

119886406(rdh5)

SCHU:

122887046(rdh5)

CUD:	121507237(rdh5)

ALAT:

119021367(rdh5)

MZE:

101481430

ONL:	100710882(rdh5)

OAU:	116326849(rdh5)

OLA:	100125503(rdh5)

OML:	112145338(rdh5)

CSAI:

133449283(rdh5)

XMA:

102227238

XCO:

114135012

XHE:

116710304

PRET:

103464826

PFOR:

103150135(rdh5)

PLAI:

106952142(rdh5)

PMEI:

106923335(rdh5)

GAF:	122833903(rdh5)

PPRL:

129355668(rdh5)

CVG:	107103450(rdh5)

CTUL:

119797824(rdh5)

GMU:	124857132(rdh5)

NFU:	107385384(rdh5)

KMR:	108231532(rdh5)

ALIM:

106517650(rdh5)

NWH:	119411860(rdh5)

AOCE:

111576058(rdh5)

MCEP:

125006507(rdh5)

CSEM:

103386710(rdh5)

POV:	109635450(rdh5)

SSEN:

122768312(rdh5)

HHIP:

117761343(rdh5)

HSP:	118104741(rdh5)

SMAU:

118309862(rdh5)

LCF:	108902106(rdh5)

SDU:	111233581(rdh5)

SLAL:

111655098(rdh5)

XGL:	120783021(rdh5)

HCQ:	109521663(rdh5)

SSCV:

125977041

SBIA:

133507465(rdh5)

PEE:	133408739(rdh5)

PTAO:

133484216(rdh5)

BPEC:

110173750(rdh5)

MALB:

109969798(rdh5)

BSPL:

114856142(rdh5)

SJO:	128356259(rdh5)

SASA:

106566157 106583706

STRU:

115150055 115207307

OTW:

112246300

OMY:	110519410 110529045

OGO:	124003926 124018490

ONE:

115122218

OKI:	109879791 109890309

OKE:	118389435 118400627

SALP:

111970500

SNH:	120023979 120065517

CCLU:

121574737(rdh5)

ELS:

105007069

SFM:	108928371 114909360

AANG:

118211649(rdh5)

LOC:

102694797

PSPA:

121307122

ARUT:

117401139 117966981

PSEX:

120526491(rdh5)

LCM:

102365116

CMK:	103180707(rdh5)

CPLA:

122543285(rdh5)

HOC:	132805767(rdh5)

DSV:	119463870 119463874

RSAN:

119401518 119402626

VDE:

111247750

VJA:

111264885

MMER:

123531040

RPHI:

132729680 132737693 132755000

OSN:

115215065

EPA:	110231798 110254791

PDAM:

113684761

SPIS:

111327939

BBIG:

BBBOND_0107740

EHX:	EMIHUDRAFT_310752

» show all

Reference

1 [PMID:7836368]

Authors

Simon A, Hellman U, Wernstedt C, Eriksson U

Title

The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases.

Journal

J Biol Chem 270:1107-12 (1995)
DOI:10.1074/jbc.270.3.1107

Sequence

[bta:281448]

Reference

2 [PMID:9931293]

Authors

Wang J, Chai X, Eriksson U, Napoli JL

Title

Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue.

Journal

Biochem J 338 ( Pt 1):23-7 (1999)

Sequence

[hsa:5959]

Reference

3 [PMID:11675386]

Authors

Liden M, Romert A, Tryggvason K, Persson B, Eriksson U

Title

Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus.

Journal

J Biol Chem 276:49251-7 (2001)
DOI:10.1074/jbc.M107337200

Sequence

[hsa:5959]

Reference

4 [PMID:12536149]

Authors

Wu Z, Yang Y, Shaw N, Bhattacharya S, Yan L, West K, Roth K, Noy N, Qin J, Crabb JW

Title

Mapping the ligand binding pocket in the cellular retinaldehyde binding protein.

Journal

J Biol Chem 278:12390-6 (2003)
DOI:10.1074/jbc.M212775200

Sequence

[hsa:5959]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.315

IUBMB Enzyme Nomenclature:

1.1.1.315

ExPASy - ENZYME nomenclature database:

1.1.1.315

BRENDA, the Enzyme Database:

1.1.1.315

DBGET integrated database retrieval system