Entry
Name
L-galactose 1-dehydrogenase;
L-GalDH;
L-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+ [RN:
R07675 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme catalyses a step in the ascorbate biosynthesis in higher plants (Smirnoff-Wheeler pathway). The activity with NADP+ is less than 10% of the activity with NAD+.
History
EC 1.1.1.316 created 2011
Pathway
ec00053 Ascorbate and aldarate metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K17744 L-galactose dehydrogenase
Genes
CSAT : 104716785 104721448 104729882
BRP : 103834464 103862253(GDH)
BNA : 106405751 106441159 125590164
RSZ : 108822420 108830302 108854615 130508360
MINC : 123214637 123227460
HSYR : 120123656 120190283 120197796 120209732
LJA : Lj0g3v0243739.1(Lj0g3v0243739.1) Lj4g3v0410570.2(Lj4g3v0410570.2)
HBR : 110646467 110646472 110661187
PALZ : 118048615 118051811
SSPL : 121805512 121809633
CQI : 110681692 110685042 110740027
PSOM : 113333373 113347404
DOSA : Os12t0482700-01(Os12g0482700)
TAES : 123102293 123110451 123119474
LRD : 124652618 124653664 124660795
PVIR : 120666191 120699475
SMO : SELMODRAFT_109892 SELMODRAFT_123995 SELMODRAFT_124085 SELMODRAFT_153099
CSL : COCSUDRAFT_18370 COCSUDRAFT_34922
» show all
Taxonomy
Reference
Authors
Mieda T, Yabuta Y, Rapolu M, Motoki T, Takeda T, Yoshimura K, Ishikawa T, Shigeoka S
Title
Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate.
Journal
Sequence
Reference
Authors
Gatzek S, Wheeler GL, Smirnoff N
Title
Antisense suppression of l-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated l-galactose synthesis.
Journal
Sequence
Reference
Authors
Wheeler GL, Jones MA, Smirnoff N
Title
The biosynthetic pathway of vitamin C in higher plants.
Journal
Reference
Authors
Oh MM, Carey EE, Rajashekar CB
Title
Environmental stresses induce health-promoting phytochemicals in lettuce.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.316