Entry Name sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)
Class Oxidoreductases;BRITE hierarchy
Sysname L-threo-7,8-dihydrobiopterin:NADP+ oxidoreductase
Reaction(IUBMB) (1) L-threo-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ [RN:
R09989 ];
(2) L-threo-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+ [RN:
R09990 ]
Reaction(KEGG) Substrate L-threo-7,8-dihydrobiopterin [CPD:
C20263 ];
NADP+ [CPD:
C00006 ];
L-threo-tetrahydrobiopterin [CPD:
C20264 ]
Product Comment This enzyme, isolated from the bacterium Chlorobium tepidum, catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. cf. EC
1.1.1.153 , sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
History EC 1.1.1.325 created 2012
Pathway Orthology Genes » show all Taxonomy Reference Authors Cho SH, Na JU, Youn H, Hwang CS, Lee CH, Kang SO
Title Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum.
Journal Sequence Reference Authors Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH.
Title Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 1.1.1.325
