KEGG   ENZYME: 1.1.1.332
Entry
EC 1.1.1.332                Enzyme                                 
Name
chanoclavine-I dehydrogenase;
easD (gene name);
fgaDH (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
chanoclavine-I:NAD+ oxidoreductase
Reaction(IUBMB)
chanoclavine-I + NAD+ = chanoclavine-I aldehyde + NADH + H+ [RN:R10128]
Reaction(KEGG)
R10128
Substrate
chanoclavine-I [CPD:C09131];
NAD+ [CPD:C00003]
Product
chanoclavine-I aldehyde [CPD:C20379];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.
History
EC 1.1.1.332 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17746  chanoclavine-I dehydrogenase
Genes
MGR: MGG_02225 MGG_09087
PPEI: PpBr36_06906
PGRI: PgNI_05463
NHE: NECHADRAFT_80607
FFC: NCS54_00718400
FKR: NCS57_00758700
MAW: MAC_06985
MAJ: MAA_06739
CFJ: CFIO01_09989
GLZ: GLAREA_05925
AFM: AFUA_2G18000
ABE: ARB_04646
TVE: TRV_01860
 » show all
Reference
1  [PMID:20039019]
  Authors
Wallwey C, Matuschek M, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH.
  Journal
Arch Microbiol 192:127-34 (2010)
DOI:10.1007/s00203-009-0536-1
  Sequence
[afm:AFUA_2G18000]
Reference
2  [PMID:22403186]
  Authors
Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM
  Title
Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.
  Journal
Microbiology 158:1634-44 (2012)
DOI:10.1099/mic.0.056796-0
  Sequence
[abe:ARB_04646]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.332
IUBMB Enzyme Nomenclature: 1.1.1.332
ExPASy - ENZYME nomenclature database: 1.1.1.332
BRENDA, the Enzyme Database: 1.1.1.332

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (14)   
Protein sequence (16)   
   UniProt (8)   
   SWISS-PROT (8)   
Protein domain (2)   
   InterPro (2)   
All databases (47)   

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