KEGG   ENZYME: 1.1.1.333
Entry
EC 1.1.1.333                Enzyme                                 
Name
decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase;
decaprenylphospho-beta-D-ribofuranose 2'-epimerase;
Rv3791;
DprE2
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
trans,octacis-decaprenylphospho-beta-D-arabinofuranose:NAD+ 2-oxidoreductase
Reaction(IUBMB)
trans,octacis-decaprenylphospho-beta-D-arabinofuranose + NAD+ = trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + NADH + H+ [RN:R10113]
Reaction(KEGG)
R10113
Substrate
trans,octacis-decaprenylphospho-beta-D-arabinofuranose [CPD:C20370];
NAD+ [CPD:C00003]
Product
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose [CPD:C20369];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The reaction is catalysed in the reverse direction. The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.98.3, decaprenylphospho-beta-D-ribofuranose 2-oxidase, in the epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinoofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers.
History
EC 1.1.1.333 created 2012
Orthology
K16652  decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase
Genes
MTURv3791(dprE2)
MTVRVBD_3791
MTCMT3899
MRAMRA_3831
MTFTBFG_13825
MTBTBMG_03838
MTKTBSG_03861
MTZTBXG_003808
MTGMRGA327_23345
MTIMRGA423_23865
MTECCDC5079_3520
MTURCFBS_4020
MTLCCDC5180_3469
MTOMTCTRI2_3870
MTDUDA_3791
MTNERDMAN_4157
MTJJ112_20380
MTUBMT7199_3860(dprE2)
MTUCJ113_26460
MTUEJ114_20245
MTXM943_19475
MTUHI917_26620
MTULTBHG_03729
MTUTHKBT1_4003
MTUUHKBT2_4013
MTQHKBS1_4016
MBOBQ2027_MB3820(dpre2)
MBBBCG_3853
MBTJTY_3855
MBMBCGMEX_3854
MBKK60_039330
MBXBCGT_3652
MAFMAF_38060
MMICRN08_4180
MCEMCAN_38111
MCQBN44_120199
MCVBN43_90303
MCXBN42_90314
MCZBN45_110153
MORYMO_003942
MLEML0108
MLBMLBr00108
MPAMAP_0234c
MAOMAP4_3637
MAVIRC58_18080
MAVURE97_18115
MAVMAV_0231
MITOCO_02360
MIAOCU_02420
MIDMIP_00567
MYOOEM_02470
MCHIAN480_01210
MIROCQ_02360
MMALCKJ54_01105
MLPMLM_0177
MMANMMAN_44840(dprE2)
MSAMycsm_06178
MULMUL_4970
MMIMMAR_5353
MMAEMMARE11_51740
MLIMULP_05631
MPSEMPSD_54760(dprE2)
MSHOMSHO_08650(dprE2)
MMCMmcs_5001
MKMMkms_5089
MJLMjls_5382
MMMW7S_01160
MKNMKAN_14105
MYVG155_28560
MYEAB431_27990
MHADB586_03110
MDXBTO20_02380
MSHGMSG_04855(dprE2)
MFJMFLOJ_36680(dprE2)
MSTOMSTO_41080(dprE2)
MSIMMSIM_26120
MSAKMSAS_32320(dprE2)
MKUI2456_27380
MLWMJO58_26750
MXEMYXE_02630(dprE2)
MNVMNVI_15200(dprE2)
MPAGC0J29_29535
MNMMNVM_20840(dprE2)
MGORH0P51_27385
MCOOMCOO_30240
MBAIMB901379_04791(fabG1_2)
MSEOMSEO_37880(dprE2)
MHEKJMUB5695_00223(dprE2)
MGAUMGALJ_45450(dprE2)
MLJMLAC_44420(dprE2)
MBRDMBRA_17170(dprE2)
MSHJMSHI_34010(dprE2)
MMAMK3U93_24025
MSPGF6B93_21850
MOTLTS72_25880
MLMMLPF_0132(dprE2)
MPAAMKK62_00520
MMEHM5I08_00575
MKYIWGMT90018_61330(dprE2)
MADIA7U43_04860
MWUPT015_16815
MSMMSMEG_6385
MSGMSMEI_6217
MSBLJ00_31560
MSNLI99_31565
MSHLI98_31570
MVAMvan_5628
MGIMflv_1177
MSPMspyr1_50100
MCBMycch_4980
MNED174_00355
MYNMyAD_00340
MFTXA26_57730
MPHLMPHLCCUG_00214(phbB_1)
MVQMYVA_5557
MLLB1R94_27185
MRHMycrhN_1954
MTHN4412656_04393
MHASMHAS_04505(dprE2)
MDUMDUV_45970(dprE2)
MCHTMCHIJ_16730
MDRMDOR_35150(dprE2)
MAUUNCTC10437_05392(fabG1)
MMAGMMAD_51630(dprE2)
MMORMMOR_07960
MFXMFAL_28330
MAICMAIC_02300
MIJMINS_04370
MALVMALV_38760(dprE2)
MTYMTOK_18460(dprE2)
MPSCMPSYJ_12500(dprE2)
MARZMARA_44410(dprE2)
MGADMGAD_40470(dprE2)
MHEVMHEL_24730
MSARMSAR_13480
MANYMANY_36130
MAUBMAUB_30000
MPOFMPOR_02350(dprE2)
MPHUMPHO_39730
MMUCC1S78_027900
MMATMMAGJ_28510(dprE2)
MBOKMBOE_08980(dprE2)
MFGK6L26_02945
MSEIMSEDJ_06260
MFLVNCTC10271_00223(sdh_1)
MCEEMCEL_34340
MBRML2Z93_000100
MMONEWR22_26995
MGOAFA91_04275
MHOLK3U96_01690
MSENK3U95_27490
MPAEK0O64_28085
MRFMJO55_25890
MDFK0O62_27565
MCROMI149_27910
MGROFZ046_04525
MKRMKOR_33020(dprE2)
MPAKMIU77_01110
MABMAB_0191c
MMVMYCMA_0115
MABBMASS_0189
MABLMMASJCM_0193
MCHEBB28_00985
MIZBAB75_01195
MSTEMSTE_00190
MSAOMYCSP_00870
MSALDSM43276_00168(phbB)
MJDJDM601_4099
MTER4434518_04037(actIII)
MMINMMIN_15440(dprE2)
MHIBMHIB_36880(dprE2)
MHERK3U94_22430
MVMMJO54_22490
ASDAS9A_0117
CGLCgl0189(Cgl0189)
CGBcg0237
CGUWA5_0186
CGTcgR_0268
CGSC624_01295
CGGC629_01295
CGMcgp_0237
CGJAR0_01235
CGQCGLAR1_01240
CGXSB89_01015
CEFCE0163
CDIDIP0161
CDPCD241_0160
CDHCDB402_0128
CDTCDHC01_0161
CDECDHC02_0167
CDRCDHC03_0133
CDACDHC04_0121
CDZCD31A_0164
CDBCDBH8_0164
CDSCDC7B_0120
CDDCDCE8392_0118
CDWCDPW8_0123
CDVCDVA01_0117
CDIPERS451417_00128
CJKjk2050
CURcu1957
CUACU7111_1879(dprE2)
CARcauri_0102(fabG3)
CKPckrop_2066
CPUCPFRC_00520
CPLCp3995_0105
CPGCP316_00575
CPPCpP54B96_0108
CPKCP1002_00520
CPQCPC231_00520
CPXCPI19_00520
CPZCpPAT10_0101
CORCp267_0112
COPCP31_00570
CODCp106_0104
COSCp4202_0101
COICPCIP5297_00575
COECP258_00575
COUCP162_00605
CPSECPTA_00630
CPSUCPTB_00903
CPSFCPTC_00565
CRDCRES_2121(dprE2)
CULCULC22_00148(dprE2)
CUCCULC809_00150(dprE2)
CUECULC0102_0146
CUNCul210932_0151(dprE2)
CUQCul210931_0145(dprE2)
CUZCul05146_0151(dprE2)
CUJCUL131002_0135c(dprE2)
CUSCulFRC11_0146(dprE2)
CVACVAR_2926(dprE2)
CHNA605_01280
CCNH924_00885
CTERA606_00555
CMDB841_01090
CAZCARG_00310
CFNCFAL_11520
CCGCCASEI_01390
CVTB843_00735
CGYCGLY_15750
CAXCATYP_00420
CIICIMIT_00525
CUVCUREI_00410
COADR71_1173
CDOCDOO_01145
CHMB842_00695
CSXCSING_00470
CMQB840_00770(dprE2)
CKUUL82_00350(dprE2)
CCJUL81_00545(dprE2)
CMVCMUST_00575(dprE2)
CEICEPID_00980
CTEDCTEST_00725(dprE2)
CUTCUTER_00435
CLWCLAC_00505
CDXCDES_01090(dprE2)
CSPWM42_1262
CSTACSTAT_01040
CCJZccrud_01010
CFKCFRA_00780
CPHOCPHO_00625
CFCCFLV_00895
CGVCGLAU_00460(phbB)
CSTRCBE89_00370
CAQUCAQU_00420
CSPHCSPHI_00375
CAMGCAMM_01045
CMINNCTC10288_02446(fabG3)
CPEGCPELA_00615
CXEFOB82_05990
CEECENDO_00730
CSANE3227_03605
CGKCGERO_00610(acr1)
CRFFRC0190_00166
CRLNCTC7448_00916(actIII_2)
CCHOCCHOA_11385
CPRECsp1_26070(dprE2)
CPSOCPPEL_00585
CSURN24_0305
CCYSSAMEA4530656_2418
CMATHBA49_07755
CYZC3B44_00545
CKFI6I12_00415
CANSGP473_09060
CLIAC3E79_00520
CPRPI6I69_06365
CAMCI6I65_08010
CGLUI6J20_08730
CUOCUROG_10235(fabG3)
CLIZG7Y31_00490
CSILCBE74_00690
CTUBI6I74_05845
CLUJIAU68_00435
CQNG7Y29_00430
CKWCKALI_00890(acr1)
CCOECETAM_01075(phbB)
COKCOCCU_01120(phbB)
CZOIAU67_00300
CORYFQV43_00385
CMFGWO64_000645
CWKIA203_01110
CUWLH390_00525
CPOYGP475_00875
CACCCACC_00600(phbB)
CFYI6L56_08885
CPSLKBP54_00555
CHINJ5O04_00680
CJHCJEDD_00440(fabG1)
CPSPL9H27_00575
CMASCMASS_00515
CHEICHEID_10275(fabG4)
CIHUCIHUM_00410(novJ)
CCOYCCOY_00470(fabG1)
CHADCHAD_00455(fabG1)
CFGCFREI_00365(phbB)
CAQMCAQUA_00570(phbB)
CCAWCCANI_00360
CAUICAURIS_00605(phbB)
CFACCFAEC_00740(phbB)
CFOUCFOUR_00420(novJ)
CFEUCFELI_00595(phbB)
CAUSCAURIC_11120(fabG3)
CATRCATRI_00730(phbB)
CDURCDUR_00525(bdcA)
CCOUCCONF_00650(phbB)
CHANCHAN_00590(phbB)
CAFECAFEL_00440(novJ)
CGFCGUA_00715(novJ)
CGOICGOTT_00480(fabG1)
CAPPCAPP_00380(phbB)
CBOVCBOVI_10305(fabG3)
CSUEQP029_04655
CBREQP027_00210
CPYRCYJ47_11630
CRIEAK829_09460
BFVC628_01130
NFANFA_1960
NFRERS450000_04042(fabG_23)
NCYNOCYR_0154
NBRO3I_000800
NNONONO_c01580
NSLBOX37_00865
NSRNS506_00807
NTPCRH09_00875
NOZDMB37_21820
NODFOH10_30710
NAHF5544_00920
NADNCTC11293_00940
NWLNWFMUON74_01370
NIEKV110_00785
NTCKHQ06_06820
NHUH0264_02050
NYALTV02_30725
NGPLTT66_13635
NSPUIFM12276_65810(dprE2)
NYUD7D52_25060
RHARHA1_ro04077
RERRER_02340
REYO5Y_01180
REBXU06_01195
RQIC1M55_01200
ROPROP_39520
ROAPd630_LPD00475
RPYY013_17545
RBYCEJ39_03950
RHBNY08_3925
RAVAAT18_01575
RFAA3L23_02041(dprE2)
RHSA3Q41_01322(dprE2)
RHWBFN03_17035
RRZCS378_17755
RHUA3Q40_03630(dprE2)
RHQIM25_07480
RHODAOT96_11755
RRT4535765_00239(fabG1_1)
RCRNCTC10994_02453
RTMG4H71_09065
RKOJWS14_22275
RGOKYT97_20770
ROZCBI38_02295
RPSKJWS13_22670
RGORNMQ04_00910
RHOPD8W71_02485
REQREQ_02320
PDEFP9209_02040
WHROG579_11245
GBRGbro_0251
GPOGPOL_c04380
GORKTR9_0242
GOQACH46_01265
GTABCM27_01670
GOCCXX93_02020
GITC6V83_02245
GRUGCWB2_01065(phbB1)
GOMD7316_03428(dprE2)
GAVC5O27_03560
GODGKZ92_01375
GAMGII34_22480
GPDGII33_21990
GJIH1R19_01140
GOILK459_07705
GHNMVF96_01695
GAMIIHQ52_03155
GMGNWF22_11120
GSIP5P27_00020
SPINKV203_00980
TPRTpau_4120
TSMASU32_23385
TPULTPB0596_44970(dprE2)
TSDMTP03_46350(dprE2)
SRTSrot_2817
DTMBJL86_0253
DITC3V38_07705
DIZCT688_01495
DPCA6048_01530
DLUA6035_01880
DKNNHB83_01425
CBQAL705_03990
TOYFO059_02215
SCOSCO4841(SC5G8.09c)
SALBXNR_3917
SMASAVERM_3415
SGRSGR_2700
SGBWQO_22060
SFISFUL_4634
SANLKZO11_23330
SGRFSGFS_073490
SCYER2B67_12745
SCBSCAB_35581
SSXSACTE_4091
SVLStrvi_8623
SHYSHJG_5969
SHOSHJGH_5731
SRCM271_28580
SFASfla_2402
SVESVEN_4516
SDVBN159_3567
SALSSLNWT_4765
STRPF750_4396
SCIB446_22725
SLVSLIV_14165
SGUSGLAU_20825
SVTSVTN_23460
SCWTU94_20215
SAMBSAM23877_4656
SCZABE83_13215
SCXAS200_19540
SRWTUE45_05364(sdh_3)
STRFASR50_22165
SLEsle_28330(sle_28330)
SPAVSpa2297_20435
STRTA8713_19405
SCLFBB341_09895
SGSAVL59_04990
STSIA4E84_25050
SKYD0C37_21260
SALWCP975_21675
SGMGCM10017557_30730
SCADDN051_16180
SPHWNFX46_04460
SLSSLINC_5218
SPLULK06_020430
STRDNI25_14740
SNWBBN63_12210
SSIAA7J05_14380
SVUB1H20_22425
SPUNBFF78_16755
SLAUSLA_4700
SALFSMD44_05417(dprE2)
SFKKY5_4943c
SNZDC008_21550
SGEDWG14_03283(dprE2)
SRJSRO_2910
SLKSLUN_24575
SDXC4B68_15415
SGDELQ87_15215
SQZFQU76_21315
SCYAEJ357_28635
SASTCD934_12515
SNQCP978_20700
STIRDDW44_18645
SKACP970_16545
SNKCP967_12785
SHAWCEB94_25445
SFICEIZ62_12330
SGALCP966_22555
SSPODDQ41_21400
SPADDVK44_21720
SFYGFH48_16755
SAQUEJC51_30025
SGFHEP81_03118
SCAVCVT27_21395
SSEOD0Z67_17890
SRIMCP984_15075
SPHVF9278_31340
SCINCP977_21255
SFUGCNQ36_21810
SPACB1H29_14255
STSUB7R87_20995
SCHACP983_16540
SGXH4W23_24910
SCOECP976_26875
SSPBCP982_26060
SBROGQF42_26795
STUIGCM10017668_43890
SATAC5746_25480
SCHFIPT68_22175
SHUNDWB77_03069(dprE2)
SCYGS1361_24175(sdh3)
SFEUIM697_39695
SLIAHA039_12655
SVDCP969_23885
SCALI6J39_22175
SROIIAG44_15195
SXNIAG42_13510
SHKJ2N69_22740
SDDD9753_13565
SACTDMT42_24065
SLFJEQ17_18490
SDECL3078_28860
SAOVG3H79_13725
SDURM4V62_17590
SRUGF0345_09990
SAKBK1J60_16520
STAALDH80_16000
SVIOHWN34_19840
SCAEIHE65_16770
STUBMMF93_13010
SSPNLXH13_16660
SCIRSTRCI_005005
SLONLGI35_27085
STEEF3L20_04030
SARGHKX69_13220
SJNRI060_15485
SFIYF0344_13280
SKGKJK29_13305
SCOAQU709_15635
SLAIP8A22_14850
SFPQUY26_14600
SINNABB07_14685
KABB7C62_22820
YIALO772_25025
STRHGXP74_34860
ABRYNYE86_30815
PFRPFREUD_16000
PFRERM25_1516
PACDEGX94_03095
PAUSNCTC13651_00709(fabG_3)
MPHMLP_13370
MIKFOE78_07070
MICGGJV80_22895
RAINRai3103_01065
PRVG7070_12065
BRTJ4N02_05120
PROPQQ658_09470
BROObrsh051_06150
NANOG5V58_07500
AEBC6I20_05965
AEFGEV26_07195
MGGMPLG2_2493(dprE)
TFUTfu_2462
TALXFOF52_12540
NDANdas_0271
NALB005_3139
NGVCDO52_23770
NEXNE857_07535
NAKEKGD83_24475
NCGKGD84_26155
STRREKD16_04945(sdh1)
SNAHOUQ99_26000
SAIUJ4H86_11745
TBITbis_0813
BLAPMVA48_19910
MMARMODMU_4724
KRAKrad_3873
SENSACE_0193
SACGFDZ84_12695
SVISvir_01390
SACCEYD13_00800(phbB)
AMDAMED_0229
AMNRAM_01160
AMMAMES_0224
AMZB737_0225
AOIAORI_0234
AJAAJAP_01215(dprE2)
AMQAMETH_0248
AMYCCU254_40420
AMYBBKN51_35270
AABA4R43_28135
AMYYYIM_01225(fabG3)
AORISD37_40620
AACDLWP59_00900
APRTMUY14_35500
AROONQK81_26855
ATHML1857_03635
ARHDVSH64_38270
PDXPsed_0194
PSEAWY02_17160
PSEEFRP1_25605
PSEHXF36_24960
PSEQAD006_04785
PECQAD017_12605
PHHAFB00_10275
PAUTPdca_01830
PBROHOP40_07200
PPELH6H00_07615
KBUQ4V64_32215
KPHYAOZ06_00970
ALOCRK60916
PMADBAY61_00865
SACEGIY23_00730
ACTUActkin_00163(fabG_2)
ACTYOG774_19290
ACTLL3i22_066840
PFLAPflav_011940
CAICaci_5663
AEYCDG81_00790
ABAIIMCC26256_111382
AFOAfer_1741
AYMYM304_25060
AQZKSP35_00295
IAMHC251_09565
IMAPO878_13030
DHILH044_19675 LH044_20390
 » show all
Reference
1  [PMID:22188377]
  Authors
Trefzer C, Skovierova H, Buroni S, Bobovska A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikusova K, Johnsson K
  Title
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1.
  Journal
J Am Chem Soc 134:912-5 (2012)
DOI:10.1021/ja211042r
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.333
IUBMB Enzyme Nomenclature: 1.1.1.333
ExPASy - ENZYME nomenclature database: 1.1.1.333
BRENDA, the Enzyme Database: 1.1.1.333

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