KEGG ENZYME: 1.1.1.337

ENZYME: 1.1.1.337

Entry

EC 1.1.1.337                Enzyme

Name

L-2-hydroxycarboxylate dehydrogenase (NAD+);
(R)-sulfolactate:NAD+ oxidoreductase;
L-sulfolactate dehydrogenase;
(R)-sulfolactate dehydrogenase;
L-2-hydroxyacid dehydrogenase (NAD+);
ComC

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase

Reaction(IUBMB)

a (2S)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+ [RN:R10189]

Reaction(KEGG)

R10189 > R07136

Substrate

(2S)-2-hydroxycarboxylate [CPD:C15565];
NAD+ [CPD:C00003]

Product

2-oxocarboxylate [CPD:C00161];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate [3]. Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.

History

EC 1.1.1.337 created 2012

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K05884

L-2-hydroxycarboxylate dehydrogenase (NAD+)

Genes

VSH:	BSZ05_08715

WBO:	MIS45_08080

CNC:	CNE_BB1p05710(comC)

CUH:	BJN34_35490

PACS:

FAZ98_33455

PWU:	A8O14_06820

PARD:

DN92_02155

PNR:	AT302_16585

BFZ:	BAU07_07535

BGV:	CAL12_19730

ADY:	HLG70_07725

PUS:	CKA81_13830

PIG:	EGT29_10430

RHOB:

HTY51_03820

LIM:	L103DPR2_01654(yjmC)

HYN:	F9K07_00765

HGR:	DW355_02340

XYG:	R9X41_06580

BPRC:

D521_0584

SMK:	Sinme_5353

SMQ:	SinmeB_5546

SMX:	SM11_pC1598

SMI:	BN406_04935

SMEG:

C770_GR4pC1290

SMEL:

SM2011_a0265

SMER:

DU99_24705

SFH:	SFHH103_06683(mdh)

SIX:	BSY16_5575

RIR:	BN877_p0363

RJG:	CCGE525_30300

SHZ:

shn_26825

BROS:

QUH67_25525

APOL:

K9D25_08275

RHZ:	RHPLAN_59280

DEQ:	XM25_09010

DEI:	C4375_14185

YTI:	FNA67_12740

MMED:

Mame_04860(yjmC_2)

JAV:	OXU80_24995

PSIN:

CAK95_00810

TSO:	IZ6_03830(mdh_2)

OTM:	OSB_08100(yjmC)

SUAM:

BOO69_02845

DAA:	AKL17_3266

SEDI:

EBB79_05045

LIT:	FPZ52_15805

PALW:

PSAL_017020(allD)

GCE:	KYE46_09560

SCIB:

HUG20_05110

SCIA:

HUG15_07015

PAUN:

MJA45_24680

LMUL:

PUW59_04940

LRU:	HMPREF0538_21967

LRT:

LRI_1196

LRR:	N134_04225

LMU:	LBLM1_05130

LOR:	AYI71_01210

LCY:	LC20004_10680

THL:	TEH_05010(mdh)

TOO:	C7K38_02045

TKR:	C7K43_11960

VIE:	OL234_00735

CRN:	CAR_c14810(mdh)

CVD:	LHA31_11755

DINC:

QNK01_01660

CAC:

CA_C0566

CAE:	SMB_G0579(mdh)

CAY:

CEA_G0580

CKL:	CKL_2769(mdh)

CKR:

CKR_2460

CLJ:	CLJU_c05920(mdh)

CLS:	CXIVA_05030

CPAS:

Clopa_1152

CPAT:

CLPA_c31190(mdh)

CPAE:

CPAST_c31190(mdh)

CAH:	CAETHG_2689

CTYK:

CTK_C26970(mdh)

CARG:

RSJ17_10995

CFER:

D4Z93_02490

CLOS:

DMR38_02690

PROQ:

P6M73_04985

RUM:	CK1_23260 CK1_39560

PFAA:

MM59RIKEN_02120

FWA:	DCMF_19385

AWO:	Awo_c16770(mdh)

AWI:	CHL1_001481

ALKA:

J0B03_10230

CCT:

CC1_29650

ROB:

CK5_14170

BYL:	A4V09_10375

BHAN:

CGC63_01920

BPRO:

PMF13cell1_03197(yjmC_2)

BLAB:

EYS05_03090

BWX:	NQ550_21270

BMAS:

LK422_14620

BLAR:

LC508_08005

BLUI:

Blut17040_23370

BCOC:

BLCOC_22890(yjmC)

CSH:	Closa_3084

ACHT:

bsdcttw_20390

QDO:	H9Q78_05115

WHJ:	H9Q79_05195

CBAR:

PATL70BA_1096(mdh)

MDV:	C5Q96_04090

MNL:	QU661_05675

PEB:	O0R46_08030

EAC:	EAL2_808p02730(mdh)

TEP:	TepRe1_1808

TAE:	TepiRe1_1949(mdh)

VNK:	VEIT17_15940

VRG:	OKW85_08395

ERM:	EYR00_09930

TSF:	NQ543_04255

TBK:	HF295_08465

OLS:

Olsu_0270

DDT:	AAY81_05455

MTY:	MTOK_02180

SLE:	sle_01170(sle_01170)

SGE:	DWG14_06080(dpkA)

SVD:	CP969_00545

VAB:	WPS_25360 WPS_25370

MTAR:

DF168_01575(yjmC_4)

LCRE:

Pla8534_16970(yjmC)

SDYN:

Mal52_06970(yjmC)

TAER:

GT409_05910

TPI:	TREPR_3329

SPER:

EW093_13865

OCK:	EXM22_12545

SBU:	SpiBuddy_0633

SGP:	SpiGrapes_1364

SASS:

MUG09_03720 MUG09_13845

SCC:	Spico_1555

TAZ:	TREAZ_1631

TAQU:

KDW03_08540

MSIL:

METEAL_16280

MSEA:

METESE_14790

ACO:	Amico_1325 Amico_1663

PYY:	RAH42_07425

ARAM:

KAR29_04645

ANF:

AQPE_3448

CBAE:

COR50_00710

CHIT:

FW415_08115

COY:	HF329_20415

CFIL:

MYF79_30070

CHOR:

MKQ68_17325

CSAC:

SIO70_31215

NKO:	Niako_5052

NSO:	NIASO_00405

NYN:	U0035_08525

FGG:	FSB75_01485

AGI:	FSB73_14960

ATEE:

K9M52_14285

PGIN:

FRZ67_22035

LACS:

H4075_07420

FEI:	K9M53_13855

FLP:	LK994_01670

FLC:	KJS93_10890

FLV:	KJS94_08280

THEO:

IMW88_12050

PSN:	Pedsa_2198

CAMU:

CA2015_1167

BBD:	Belba_1791

EVI:	Echvi_0162

EST:	DN752_07350

ECHI:

FKX85_00785

ALGO:

GYM62_13805

MDA:	IPZ59_00985

SPIK:

EXU85_28470

SPIB:

G8759_30960

SRHO:

HH216_11020

SOQ:	LQ777_19275

SFOL:

H3H32_24840

SENF:

GJR95_20605

DSN:	HWI92_12955

DFQ:	NFI81_13340

DCN:	MUK70_16695

DPF:	ON006_18525

RSI:	Runsl_0559

RUN:	DR864_22800

RUP:	DTQ70_27545

EMZ:	MB380_09155

HSW:

Hsw_3558

HYM:	N008_11585

HYG:	AUC43_08190

HYP:	A0257_10070

HYZ:	AXW84_17735

HNV:	DDQ68_12555

HRS:	HER32_07605

HTS:	HMJ29_03810

HMT:	MTP16_02030

HTB:	MTX78_19255

HYK:	O9Z63_13890

HSK:	H4317_03670

HCW:	O3303_11905

HSB:	MWH26_14695

HAEI:

MUN82_20995

HCU:	MUN79_00150

HCF:	MUN80_00740

RUF:	TH63_01270

RTI:	DC20_19730

RUD:	TH61_09780

ADD:	HUW48_20385

ASWU:

HUW51_03165

MHAA:

Q3Y49_09305

FPF:	DCC35_04490

FLM:	MY04_2484 MY04_2897

FYA:	KMW28_01625 KMW28_03820

FKA:	KM029_13735 KM029_15620

CLIT:

OQ292_06510

IRO:	RT717_18950

CHK:	D4L85_06045

FUV:	JR347_01350

FMM:	LVD15_12685

FUA:	LVD17_13565

FLW:	LVD16_07150

RCG:	N7E81_11175

PRHO:

PZB74_01255

TPEL:

P0M28_24940

RSR:	T7867_10340

FAX:	FUAX_10320

PPSV:

PEPS_23260

ATK:	AUTU_05100

LUY:	QZH61_12165

SHYR:

LA303_06570

CACI:

CLOAM1159(mdh)

KPF:	IX53_06400

MPG:	Theba_0594

MINF:

MESINF_0035(mdh) MESINF_1540(mdh)

BANA:

BARAN1_1319(mdh)

MJA:

MJ_1425

MFE:	Mefer_1396

MVU:	Metvu_0738

MFS:	MFS40622_0628

MIF:	Metin_0176

MJH:	JH146_0548

MESG:

MLAUSG7_0644(comC)

MESA:

MLASG1_0181(comC)

MIG:	Metig_0716

MMP:	MMP1133(comC)

MMQ:	MmarC5_0451

MMX:	MmarC6_1534

MMZ:	MmarC7_0385

MMD:

GYY_06515

MMAK:

MMKA1_13120(comC)

MMAO:

MMOS7_12420(comC)

MMAD:

MMJJ_17120(yjmC)

MAE:

Maeo_1015

MVN:	Mevan_0455

MVO:

Mvol_0905

MOK:	Metok_0546

METF:

CFE53_04010

MTH:

MTH_1205

MMG:	MTBMA_c15830(comC)

MWO:	MWSIV6_1598(comC)

MTEE:

MTTB_02220

METC:

MTCT_1098

METE:

tca_01162(yjmC)

METZ:

METMT2_1207

METK:

FVF72_05595

MTHM:

FZP57_07660

METJ:

FZP68_03015

MST:	Msp_0279(comC)

METB:

AW729_05750

MEIS:

PXD04_05160(comC)

MRU:	mru_1980(comC)

MSI:

Msm_1040

MEB:	Abm4_1552(comC)

MMIL:

sm9_2052(comC)

MEYE:

TL18_09445

MOL:

YLM1_1417

MARO:

MarbSA_15040

METV:

K4897_06265

MEL:	Metbo_0320

MEW:	MSWAN_2101

METH:

MBMB1_1726(comC)

MFC:	BRM9_0342(comC)

MFI:	DSM1535_0956(comC)

MCUB:

MCBB_2038(comC)

MSUB:

BK009_07660

METN:

BK008_03315

METT:

CIT01_03895

METO:

CIT02_09230

MEME:

HYG87_05175

MFEG:

GCM10025860_03460

MFV:

Mfer_0389

MKA:	MK0392(comC)

HALX:

M0R89_21370

NARA:

QQ977_15230

STO:

STK_20900

SOH:	D1869_11455

SULL:

EWF20_12610

AMAN:

B6F84_09265

ABRI:

DFR85_02480 DFR85_02750

ASUL:

DFR86_07970

AAMB:

D1866_00065 D1866_09410

ACIH:

HS5_24340

SACD:

HS1genome_1813

SAZO:

D1868_06535

CSTY:

KN1_08830

STEP:

IC006_0144

LOKI:

Lokiarch_23620(mdh_3) Lokiarch_23630(mdh_4)

LOB:	NEF87_004182

PSYT:

DSAG12_01758(mdh)

» show all

Reference

1 [PMID:10850983]

Authors

Graupner M, Xu H, White RH

Title

Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea.

Journal

J Bacteriol 182:3688-92 (2000)
DOI:10.1128/JB.182.13.3688-3692.2000

Sequence

[mja:MJ_1425]

Reference

2 [PMID:11451450]

Authors

Graupner M, White RH.

Title

The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea.

Journal

Biochim Biophys Acta 1548:169-73 (2001)
DOI:10.1016/S0167-4838(01)00220-5

Sequence

[mja:MJ_1425]

Reference

3 [PMID:12013276]

Authors

Graham DE, White RH.

Title

Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.

Journal

Nat Prod Rep 19:133-47 (2002)
DOI:10.1039/b103714p

Reference

4 [PMID:15758220]

Authors

Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM

Title

Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.

Journal

Microbiology 151:737-47 (2005)
DOI:10.1099/mic.0.27548-0

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.337

IUBMB Enzyme Nomenclature:

1.1.1.337

ExPASy - ENZYME nomenclature database:

1.1.1.337

BRENDA, the Enzyme Database:

1.1.1.337

CAS:	81210-65-3

DBGET integrated database retrieval system