KEGG ENZYME: 1.1.1.339

ENZYME: 1.1.1.339

Entry

EC 1.1.1.339                Enzyme

Name

dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+);
tll (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase

Reaction(IUBMB)

dTDP-6-deoxy-beta-L-talose + NAD+ = dTDP-4-dehydro-beta-L-rhamnose + NADH + H+ [RN:R10190]

Reaction(KEGG)

R10190

Substrate

dTDP-6-deoxy-beta-L-talose [CPD:C03187];
NAD+ [CPD:C00003]

Product

dTDP-4-dehydro-beta-L-rhamnose [CPD:C00688];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+.

History

EC 1.1.1.339 created 2012

Pathway

ec00523

Polyketide sugar unit biosynthesis

ec00541

O-Antigen nucleotide sugar biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K19180

dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)

Genes

AAT:

D11S_1703

Reference

1 [PMID:10702238]

Authors

Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T

Title

Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans.

Journal

J Biol Chem 275:6806-12 (2000)
DOI:10.1074/jbc.275.10.6806

Sequence

[ag:BAA28138]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.339

IUBMB Enzyme Nomenclature:

1.1.1.339

ExPASy - ENZYME nomenclature database:

1.1.1.339

BRENDA, the Enzyme Database:

1.1.1.339

DBGET integrated database retrieval system