KEGG ENZYME: 1.1.1.340

ENZYME: 1.1.1.340

Entry

EC 1.1.1.340                Enzyme

Name

1-deoxy-11beta-hydroxypentalenate dehydrogenase;
1-deoxy-11beta-hydroxypentalenic acid dehydrogenase;
ptlF (gene name);
penF (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase

Reaction(IUBMB)

1-deoxy-11beta-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+ [RN:R10156]

Reaction(KEGG)

R10156

Substrate

1-deoxy-11beta-hydroxypentalenate [CPD:C20403];
NAD+ [CPD:C00003]

Product

1-deoxy-11-oxopentalenate [CPD:C20400];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.

History

EC 1.1.1.340 created 2012

Pathway

ec00998

Biosynthesis of various antibiotics

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K17747

1-deoxy-11beta-hydroxypentalenate dehydrogenase

Genes

SMA:	SAVERM_2993(ptlF)

SBH:

SBI_09675

SCI:	B446_29675

SCW:	TU94_27385

SLE:	sle_13200(sle_13200)

SSIA:

A7J05_09260

SGJ:	IAG43_27135

SHK:	J2N69_35825

Reference

1 [PMID:17178094]

Authors

You Z, Omura S, Ikeda H, Cane DE

Title

Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate.

Journal

Arch Biochem Biophys 459:233-40 (2007)
DOI:10.1016/j.abb.2006.11.016

Sequence

[sma:SAVERM_2993]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.340

IUBMB Enzyme Nomenclature:

1.1.1.340

ExPASy - ENZYME nomenclature database:

1.1.1.340

BRENDA, the Enzyme Database:

1.1.1.340

DBGET integrated database retrieval system