KEGG ENZYME: 1.1.1.342

ENZYME: 1.1.1.342

Entry

EC 1.1.1.342                Enzyme

Name

CDP-paratose synthase;
rfbS (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

CDP-alpha-D-paratose:NADP+ 4-oxidoreductase

Reaction(IUBMB)

CDP-alpha-D-paratose + NADP+ = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+ [RN:R04265]

Reaction(KEGG)

R04265

Substrate

CDP-alpha-D-paratose [CPD:C03598];
NADP+ [CPD:C00006]

Product

CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose [CPD:C04297];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme is involved in synthesis of paratose and tyvelose, unusual 3,6-dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria. Isolated from Salmonella enterica subsp. enterica serovar Typhi (Salmonella typhi).

History

EC 1.1.1.342 created 2012

Pathway

ec00520

Amino sugar and nucleotide sugar metabolism

ec00541

O-Antigen nucleotide sugar biosynthesis

ec01100

Metabolic pathways

Orthology

K12453

CDP-paratose synthetase

Genes

STY:	STY2299(rfbS)

STT:	t0783(rfbS)

SEX:	STBHUCCB_8350

SENT:

TY21A_03970

SPT:	SPA0777(rfbS)

SEK:

SSPA0731

SED:

SeD_A2429

SEG:

SG2120

SEL:	SPUL_0808(rfbS)

SEGA:

SPUCDC_0808(rfbS)

SET:	SEN2085D(rfbS)

SENA:

AU38_10540

SENO:

AU37_10550

SENV:

AU39_10550

SENQ:

AU40_11805

SENL:

IY59_10835

SENJ:

CFSAN001992_00980

SEEP:

I137_03630

KRD:	A3780_14940

BUF:	D8682_24050

YPE:	YPO3112(prt)

YPK:

y1071

YPH:	YPC_3391(prt)

YPA:

YPA_2604

YPN:

YPN_0978

YPM:	YP_0818(prt)

YPP:	YPDSF_2748

YPG:	YpAngola_A2900(prt)

YPZ:	YPZ3_2741(prt)

YPT:	A1122_10405

YPD:	YPD4_2729(prt)

YPX:	YPD8_2720(prt)

YPW:

CH59_2953

YPJ:

CH55_1690

YPV:

BZ15_415

YPL:

CH46_1987

YPS:	YPTB1002(prt)

YPO:

BZ17_1546

YPI:	YpsIP31758_3048(prt)

YPY:

YPK_3188

YPB:

YPTS_1045

YPU:

BZ21_245

YPC:

BZ23_521

YPF:

BZ19_359

YEW:

CH47_2459

YMO:	HRD69_10870

YEG:	PL78_00700

XBU:	HGO23_18930

VGA:	BSQ33_09850

SPOL:

FH971_05610

SDK:	KHX94_02875

SHAO:

K0H81_13435

PIN:

Ping_0776

AFRI:

E3E15_05600

TCAR:

U0034_02765

GCA:

Galf_2845

SAQT:

GJV85_09680

CCOC:

CCON33237_0121

SMUL:

SMUL_2477

AELL:

AELL_2674

APOC:

APORC_0917

HEBR:

AEBR_0586

GEF:	FO488_01055

GUR:

Gura_3787

GEO:	Geob_2127(prt)

GBM:	Gbem_0858(prt)

BCHS:

JNE38_09500

AWO:	Awo_c24770

SYNE:

Syn6312_0748

CAP:	CLDAP_10470

PFER:

IRI77_19890

ARAC:

E0W69_011185

SPSC:

E2P86_16670

MUP:	A0256_16620

FKA:	KM029_05925

FCR:	HYN56_01815

SAF:	SULAZ_1205

PMX:	PERMA_1994

» show all

Reference

1 [PMID:2793833]

Authors

Verma N, Reeves P

Title

Identification and sequence of rfbS and rfbE, which determine antigenic specificity of group A and group D salmonellae.

Journal

J Bacteriol 171:5694-701 (1989)
DOI:10.1128/JB.171.10.5694-5701.1989

Sequence

[sty:STY2299]

Reference

2 [PMID:9538012]

Authors

Hallis TM, Lei Y, Que NL, Liu H

Title

Mechanistic studies of the biosynthesis of paratose: purification and characterization of CDP-paratose synthase.

Journal

Biochemistry 37:4935-45 (1998)
DOI:10.1021/bi9725529

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.342

IUBMB Enzyme Nomenclature:

1.1.1.342

ExPASy - ENZYME nomenclature database:

1.1.1.342

BRENDA, the Enzyme Database:

1.1.1.342

DBGET integrated database retrieval system