KEGG ENZYME: 1.1.1.344

ENZYME: 1.1.1.344

Entry

EC 1.1.1.344                Enzyme

Name

dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+];
tal (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

dTDP-6-deoxy-beta-L-talose:NAD(P)+ 4-oxidoreductase

Reaction(IUBMB)

dTDP-6-deoxy-beta-L-talose + NAD(P)+ = dTDP-4-dehydro-beta-L-rhamnose + NAD(P)H + H+ [RN:R02776 R10190]

Reaction(KEGG)

R02776 R10190

Substrate

dTDP-6-deoxy-beta-L-talose [CPD:C03187];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

dTDP-4-dehydro-beta-L-rhamnose [CPD:C00688];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme works equally well with NAD+ and NADP+.

History

EC 1.1.1.344 created 2013

Pathway

ec00523

Polyketide sugar unit biosynthesis

ec00541

O-Antigen nucleotide sugar biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K19652

dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)+]

Reference

1 [PMID:20667525]

Authors

Karki S, Yoo HG, Kwon SY, Suh JW, Kwon HJ

Title

Cloning and in vitro characterization of dTDP-6-deoxy-L-talose biosynthetic genes from Kitasatospora kifunensis featuring the dTDP-6-deoxy-L-lyxo-4-hexulose reductase that synthesizes dTDP-6-deoxy-L-talose.

Journal

Carbohydr Res 345:1958-62 (2010)
DOI:10.1016/j.carres.2010.07.004

Sequence

[ag:ADO32602]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.344

IUBMB Enzyme Nomenclature:

1.1.1.344

ExPASy - ENZYME nomenclature database:

1.1.1.344

BRENDA, the Enzyme Database:

1.1.1.344

DBGET integrated database retrieval system