KEGG ENZYME: 1.1.1.347

ENZYME: 1.1.1.347

Entry

EC 1.1.1.347                Enzyme

Name

geraniol dehydrogenase (NAD+);
GeDH;
geoA (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

geraniol:NAD+ oxidoreductase

Reaction(IUBMB)

geraniol + NAD+ = geranial + NADH + H+ [RN:R10308]

Reaction(KEGG)

R10308

Substrate

geraniol [CPD:C01500];
NAD+ [CPD:C00003]

Product

geranial [CPD:C01499];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme from the bacterium Castellaniella defragrans is most active in vitro with perillyl alcohol [2]. The enzyme from the prune mite Carpoglyphus lactis also acts (more slowly) on farnesol but not on nerol [1].

History

EC 1.1.1.347 created 2013

Pathway

ec00907

Pinene, camphor and geraniol degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K19653

geraniol dehydrogenase (NAD+)

Genes

CDN:	BN940_14111

Reference

1 [PMID:18422649]

Authors

Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y

Title

Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae).

Journal

FEBS J 275:2807-17 (2008)
DOI:10.1111/j.1742-4658.2008.06421.x

Reference

2 [PMID:22286981]

Authors

Luddeke F, Wulfing A, Timke M, Germer F, Weber J, Dikfidan A, Rahnfeld T, Linder D, Meyerdierks A, Harder J

Title

Geraniol and geranial dehydrogenases induced in anaerobic monoterpene degradation by Castellaniella defragrans.

Journal

Appl Environ Microbiol 78:2128-36 (2012)
DOI:10.1128/AEM.07226-11

Sequence

[ag:CCF55024]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.347

IUBMB Enzyme Nomenclature:

1.1.1.347

ExPASy - ENZYME nomenclature database:

1.1.1.347

BRENDA, the Enzyme Database:

1.1.1.347

DBGET integrated database retrieval system