KEGG   ENZYME: 1.1.1.351
Entry
EC 1.1.1.351                Enzyme                                 
Name
phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
6-phospho-D-gluconate + NAD(P)+ = D-ribulose 5-phosphate + CO2 + NAD(P)H + H+ [RN:R01528 R10221]
Reaction(KEGG)
R01528 R10221
Substrate
6-phospho-D-gluconate [CPD:C00345];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
D-ribulose 5-phosphate [CPD:C00199];
CO2 [CPD:C00011];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP+ and can accept both cofactors with similar efficiency. cf. EC 1.1.1.343, phosphogluconate dehydrogenase [NAD+-dependent, decarboxylating].
History
EC 1.1.1.351 created 2013
Reference
1  [PMID:7350909]
  Authors
Ben-Bassat A, Goldberg I
  Title
Purification and properties of glucose-6-phosphate dehydrogenase (NADP+/NAD+) and 6-phosphogluconate dehydrogenase (NADP+/NAD+) from methanol-grown Pseudomonas C.
  Journal
Biochim Biophys Acta 611:1-10 (1980)
DOI:10.1016/0005-2744(80)90036-4
Reference
2  [PMID:6402366]
  Authors
Stournaras C, Maurer P, Kurz G
  Title
6-phospho-D-gluconate dehydrogenase from Pseudomonas fluorescens. Properties and  subunit structure.
  Journal
Eur J Biochem 130:391-6 (1983)
DOI:10.1111/j.1432-1033.1983.tb07165.x
Reference
3  [PMID:8579362]
  Authors
Levy HR, Vought VE, Yin X, Adams MJ
  Title
Identification of an arginine residue in the dual coenzyme-specific glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides that plays a key role in binding NADP+ but not NAD+.
  Journal
Arch Biochem Biophys 326:145-51 (1996)
DOI:10.1006/abbi.1996.0058
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.351
IUBMB Enzyme Nomenclature: 1.1.1.351
ExPASy - ENZYME nomenclature database: 1.1.1.351
BRENDA, the Enzyme Database: 1.1.1.351
CAS: 9073-95-4

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Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Protein sequence (5)   
   UniProt (5)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
All databases (19)   

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