KEGG ENZYME: 1.1.1.353

ENZYME: 1.1.1.353

Entry

EC 1.1.1.353                Enzyme

Name

versiconal hemiacetal acetate reductase;
VHA reductase;
VHA reductase I;
VHA reductase II;
vrdA (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

versiconol-acetate:NADP+ oxidoreductase

Reaction(IUBMB)

(1) versicolorone + NADP+ = 1'-hydroxyversicolorone + NADPH + H+ [RN:R09756];
(2) versiconol acetate + NADP+ = versiconal hemiacetal acetate + NADPH + H+ [RN:R10399];
(3) versiconol + NADP+ = versiconal + NADPH + H+ [RN:R10400]

Reaction(KEGG)

R09756 R10399 R10400

Substrate

versicolorone [CPD:C20504];
NADP+ [CPD:C00006];
versiconol acetate [CPD:C20506];
versiconol [CPD:C20508]

Product

1'-hydroxyversicolorone [CPD:C20503];
NADPH [CPD:C00005];
H+ [CPD:C00080];
versiconal hemiacetal acetate [CPD:C20505];
versiconal [CPD:C20507]

Comment

Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis.

History

EC 1.1.1.353 created 2013

Pathway

ec00254

Aflatoxin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K17647

versiconal hemiacetal acetate reductase

Genes

AOR:	AO090120000002

AFV:	AFLA_009215

Reference

1 [PMID:16349333]

Authors

Matsushima K, Ando Y, Hamasaki T, Yabe K

Title

Purification and characterization of two versiconal hemiacetal acetate reductases involved in aflatoxin biosynthesis.

Journal

Appl Environ Microbiol 60:2561-7 (1994)
DOI:10.1128/AEM.60.7.2561-2567.1994

Sequence

[ag:BAH24200]

Reference

2 [PMID:19211038]

Authors

Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K

Title

Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster.

Journal

Fungal Genet Biol 46:221-31 (2009)
DOI:10.1016/j.fgb.2008.12.005

Sequence

[ag:BAH24200]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.353

IUBMB Enzyme Nomenclature:

1.1.1.353

ExPASy - ENZYME nomenclature database:

1.1.1.353

BRENDA, the Enzyme Database:

1.1.1.353

DBGET integrated database retrieval system