KEGG ENZYME: 1.1.1.354

ENZYME: 1.1.1.354

Entry

EC 1.1.1.354                Enzyme

Name

farnesol dehydrogenase (NAD+);
NAD+-farnesol dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(2E,6E)-farnesol:NAD+ 1-oxidoreductase

Reaction(IUBMB)

(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+ [RN:R10412]

Reaction(KEGG)

R10412

Substrate

(2E,6E)-farnesol [CPD:C01126];
NAD+ [CPD:C00003]

Product

(2E,6E)-farnesal [CPD:C03461];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.

History

EC 1.1.1.354 created 2013

Pathway

ec00900

Terpenoid backbone biosynthesis

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K15891

NAD+-dependent farnesol dehydrogenase

Genes

ATH:	AT4G33360(FLDH)

ALY:

9305289

CRB:

17878851

CSAT:

104716825 104721483 104729924

EUS:	EUTSA_v10025657mg

BRP:

103862234

BNA:	106411435 111207928

BOE:

106302011

RSZ:

108848622

THJ:

104819464

CPAP:

110815277

CIT:

102617063

PVY:

116129855

MINC:

123228976

TCC:

18591229

GRA:

105769201

GHI:	107905556 107958109

GAB:

108450623

HSYR:

120190845

DZI:

111315425

EGR:

104449340

GMX:

100792747

GSJ:

114414709

PVU:	PHAVU_009G064000g

VRA:

106762372

VAR:

108343368

VUN:

114196187

CCAJ:

109801757

APRC:

113864806

MTR:

11431375

TPRA:

123914017

CAM:

101492439

PSAT:

127088158 127088159

VVO:	131655332 131655333

LJA:	Lj1g3v1649010.1(Lj1g3v1649010.1) Lj1g3v1649010.2(Lj1g3v1649010.2) Lj1g3v2584610.1(Lj1g3v2584610.1)

ADU:

107460435

AIP:

107605825

AHF:	112705833 112766223

LANG:

109340006 109343904

PCIN:

129295592 129299085

QSA:	O6P43_016080

FVE:

101307656

RCN:	112174260 112174457

PPER:

109949998

PMUM:

103320321

PAVI:

110761929

PDUL:

117634062

MDM:

103428773

MSYL:

126633132

PXB:	103941079 103949739 103949911

ZJU:

107420927

MNT:

21386905

CSAV:

115695988

CSV:

101223178

CMO:

103493529

BHJ:

120086060

MCHA:

111026159

CMAX:

111481147

CMOS:

111446335

CPEP:

111789148

RCU:

8278896

JCU:

105633659

HBR:

110664353

MESC:

110605974

POP:	112326478 7472693

PEU:	105120636 105120638

PALZ:

118057850 118057851 118062625

JRE:

108987634

CILL:

122297675

CAVE:

132185833

QSU:	112017583 112017584

QLO:	115974197 115978079

TWL:

120009004

VVI:

100266013

VRI:

117907572

SLY:

101264803

SPEN:

107005370

SOT:

102604685

SSTN:

125861995

SDUL:

129880911

CANN:

107850726 107850727

LBB:

132604102

NTA:	107760928 107771557 107803068

NSY:

104212650

NTO:	104093090 104115889

NAU:	109217688 109235514 109235516

INI:

109149773

ITR:

116021819

SIND:

105166261

OEU:	111397266 111409485

EGT:

105971449

SSPL:

121754503

SMIL:

131010859

SHIS:

125221816

APAN:

127257110 127257377

HAN:

110913581

ECAD:

122607565

LSV:	111876193 111876194

CCAV:

112511479

DCR:	108224131 108224133

CSIN:

114287572 114292023

RVL:

131331190

AEW:

130758972

BVG:

104898527

SOE:

110776702

CQI:	110696565 110696566 110709081

ATRI:

130810032

MOF:

131161713

NNU:

104610585

MING:

122070219

TSS:

122660873

PSOM:

113346636 113356818

OSA:	9269735 9272175

DOSA:

Os03t0184550-01(Os03g0184550)

OBR:	102707016 102707296

OGL:	127767169 127767170

BDI:

100829741

ATS:

109735166

TDC:	119288494 119291687

TAES:

123093424 123098702

TUA:

125552857

LPER:

127297005

LRD:	124696291 124696327

SBI:	8057655 8082002

ZMA:

100272889

SITA:

101767860 101768265

SVS:	117838560 117838561

PVIR:

120647065 120647068 120690899 120691876

PHAI:

112874069 112878075

PDA:

103701809

EGU:

105048681

MUS:

103971350

ZOF:	122008974 122014952

DCT:

110101245

PEQ:

110027609

AOF:

109848345

MSIN:

131236061

NCOL:

116261978 116262597

ATR:

18425069

SMO:	SELMODRAFT_111632 SELMODRAFT_234795

PPP:

112293999

MBAS:

ALGA_3274

PGIN:

FRZ67_16760

MUC:

MuYL_4365

MUH:	HYN43_025140

MGK:	FSB76_26125

MRUB:

DEO27_027385

MGOS:

DIU38_028775

» show all

Reference

1 [PMID:18422649]

Authors

Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y

Title

Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae).

Journal

FEBS J 275:2807-17 (2008)
DOI:10.1111/j.1742-4658.2008.06421.x

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.354

IUBMB Enzyme Nomenclature:

1.1.1.354

ExPASy - ENZYME nomenclature database:

1.1.1.354

BRENDA, the Enzyme Database:

1.1.1.354

DBGET integrated database retrieval system