KEGG ENZYME: 1.1.1.358

ENZYME: 1.1.1.358

Entry

EC 1.1.1.358                Enzyme

Name

2-dehydropantolactone reductase;
2-oxopantoyl lactone reductase;
2-ketopantoyl lactone reductase;
ketopantoyl lactone reductase;
2-dehydropantoyl-lactone reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(R)-pantolactone:NADP+ oxidoreductase

Reaction(IUBMB)

(R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+ [RN:R03155]

Reaction(KEGG)

R03155

Substrate

(R)-pantolactone [CPD:C01012];
NADP+ [CPD:C00006]

Product

2-dehydropantolactone [CPD:C01125];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme participates in an alternative pathway for biosynthesis of (R)-pantothenate (vitamin B5). This entry covers enzymes whose stereo specificity for NADP+ is not known. cf. EC 1.1.1.168 2-dehydropantolactone reductase (Re-specific) and EC 1.1.1.214, 2-dehydropantolactone reductase (Si-specific).

History

EC 1.1.1.358 created 2013

Orthology

K19654

2-dehydropantolactone reductase

Genes

LEL:	PVL30_005294(CPRC2)

CTP:	CTRG_05139

COT:	CORT_0G03830

CDU:	CD36_73000(CPR-C2)

CAUR:

CJI96_0003456

Reference

1 [PMID:2644973]

Authors

Hata H, Shimizu S, Hattori S, Yamada H

Title

Ketopantoyl-lactone reductase from Candida parapsilosis: purification and characterization as a conjugated polyketone reductase.

Journal

Biochim Biophys Acta 990:175-81 (1989)
DOI:10.1016/S0304-4165(89)80031-5

Sequence

[ag:BAD01653]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.358

IUBMB Enzyme Nomenclature:

1.1.1.358

ExPASy - ENZYME nomenclature database:

1.1.1.358

BRENDA, the Enzyme Database:

1.1.1.358

DBGET integrated database retrieval system