KEGG   ENZYME: 1.1.1.359
Entry
EC 1.1.1.359                Enzyme                                 
Name
aldose 1-dehydrogenase [NAD(P)+]
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
an aldopyranose:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
an aldopyranose + NAD(P)+ = an aldono-1,5-lactone + NAD(P)H + H+ [RN:R10428 R10429]
Reaction(KEGG)
R10428 > R08544;
R10429 > R01096 R07147
Substrate
aldopyranose [CPD:C20655];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
aldono-1,5-lactone [CPD:C20616];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity towards aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD+ and NADP+ with similar catalytic efficiency. It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway.
History
EC 1.1.1.359 created 2013
Pathway
ec00030  Pentose phosphate pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18125  aldose 1-dehydrogenase [NAD(P)+]
Genes
PTO: PTO0639
FAC: FACI_IFERC01G0109
FAI: FAD_1034
STO: STK_17040(gdh)
SOH: D1869_09575
SSO: SSO3003(dhg-1) SSO3042(dhg-2) SSO3204(dhg-3)
SOL: Ssol_0792 Ssol_0941
SSOA: SULA_0783 SULA_0820 SULA_0974
SSOL: SULB_0785 SULB_0822 SULB_0976
SSOF: SULC_0783 SULC_0820 SULC_0975
SSHI: J5U23_00294 J5U23_00444 J5U23_00501
SCAS: SACC_30460 SACC_31420
SAI: Saci_1079
SACN: SacN8_05250
SACR: SacRon12I_05240
SACS: SUSAZ_05025
SIS: LS215_2319 LS215_2487 LS215_2525
SIA: M1425_2156 M1425_2315 M1425_2353
SIM: M1627_2236 M1627_2394 M1627_2431
SID: M164_2160 M164_2317 M164_2360
SIY: YG5714_2283 YG5714_2452 YG5714_2497
SIN: YN1551_0407 YN1551_0458 YN1551_0633
SII: LD85_2423 LD85_2603 LD85_2656
SIH: SiH_2102 SiH_2256 SiH_2295
SIR: SiRe_2034 SiRe_2200 SiRe_2243
SIC: SiL_2009 SiL_2165 SiL_2203
SULA: BFU36_06060 BFU36_07060 BFU36_07270
SULE: GFS03_11745 GFS03_12475 GFS03_12660
SULO: GFS33_03555 GFS33_04540
SULL: EWF20_10710
MSE: Msed_1301
MEMJ: MJ1HA_1509
MCN: Mcup_0902
MHK: DFR87_11970
MPRU: DFR88_11815
MTEN: GWK48_00425
MJN: MjAS7_2196 MjAS7_2216 MjAS7_2369
AHO: Ahos_2067
AMAN: B6F84_01630 B6F84_05020
ABRI: DFR85_11645 DFR85_12080
ASUL: DFR86_01625 DFR86_04395
AAMB: D1866_05350
ACIH: HS5_08840
SACD: HS1genome_0652 HS1genome_1599
SAZO: D1868_03195
CSTY: KN1_23070
STEP: IC006_0170
SMET: RQ359_001431
SAHS: HS7_05220
CMA: Cmaq_1714
VSO: Vsou_17260
CCAI: NAS2_0753
 » show all
Reference
1  [PMID:3827812]
  Authors
Giardina P, de Biasi MG, de Rosa M, Gambacorta A, Buonocore V
  Title
Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus.
  Journal
Biochem J 239:517-22 (1986)
DOI:10.1042/bj2390517
Reference
2  [PMID:2803257]
  Authors
Smith LD, Budgen N, Bungard SJ, Danson MJ, Hough DW
  Title
Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum.
  Journal
Biochem J 261:973-7 (1989)
DOI:10.1042/bj2610973
Reference
3  [PMID:12824170]
  Authors
Lamble HJ, Heyer NI, Bull SD, Hough DW, Danson MJ
  Title
Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase.
  Journal
J Biol Chem 278:34066-72 (2003)
DOI:10.1074/jbc.M305818200
  Sequence
[sso:SSO3003]
Reference
4  [PMID:16508107]
  Authors
Theodossis A, Milburn CC, Heyer NI, Lamble HJ, Hough DW, Danson MJ, Taylor GL
  Title
Preliminary crystallographic studies of glucose dehydrogenase from the promiscuous Entner-Doudoroff pathway in the hyperthermophilic archaeon Sulfolobus solfataricus.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 61:112-5 (2005)
DOI:10.1107/S174430910403101X
Reference
5  [PMID:16556607]
  Authors
Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL
  Title
The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.
  Journal
J Biol Chem 281:14796-804 (2006)
DOI:10.1074/jbc.M601334200
  Sequence
[sso:SSO3003]
Reference
6  [PMID:21265750]
  Authors
Haferkamp P, Kutschki S, Treichel J, Hemeda H, Sewczyk K, Hoffmann D, Zaparty M, Siebers B
  Title
An additional glucose dehydrogenase from Sulfolobus solfataricus: fine-tuning of sugar degradation?
  Journal
Biochem Soc Trans 39:77-81 (2011)
DOI:10.1042/BST0390077
  Sequence
[sso:SSO3003]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.359
IUBMB Enzyme Nomenclature: 1.1.1.359
ExPASy - ENZYME nomenclature database: 1.1.1.359
BRENDA, the Enzyme Database: 1.1.1.359

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Pathway (8)   
   KEGG PATHWAY (8)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (6)   
   KEGG REACTION (5)   
   KEGG RCLASS (1)   
Gene (96)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (95)   
Protein sequence (3)   
   UniProt (2)   
   SWISS-PROT (1)   
Protein domain (6)   
   InterPro (6)   
All databases (130)   

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