KEGG ENZYME: 1.1.1.362

ENZYME: 1.1.1.362

Entry

EC 1.1.1.362                Enzyme

Name

aklaviketone reductase;
dauE (gene name);
aknU (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

aklavinone:NADP+ oxidoreductase

Reaction(IUBMB)

aklavinone + NADP+ = aklaviketone + NADPH + H+ [RN:R06682]

Reaction(KEGG)

R06682;
(other) R06677

Substrate

aklavinone [CPD:C12424];
NADP+ [CPD:C00006]

Product

aklaviketone [CPD:C12423];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.

History

EC 1.1.1.362 created 2013

Pathway

ec01057

Biosynthesis of type II polyketide products

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K15944

nogalaviketone/aklaviketone reductase