KEGG   ENZYME: 1.1.1.380
Entry
EC 1.1.1.380                Enzyme                                 
Name
L-gulonate 5-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-gulonate:NAD+ 5-oxidoreductase
Reaction(IUBMB)
L-gulonate + NAD+ = D-fructuronate + NADH + H+ [RN:R10848]
Reaction(KEGG)
R10848
Substrate
L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]
Product
D-fructuronate [CPD:C00905];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Halomonas elongata, participates in a pathway for L-gulonate degradation.
History
EC 1.1.1.380 created 2014
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K08322  L-gulonate 5-dehydrogenase
Genes
ECO: b1580(rspB)
ECJ: JW1572(rspB)
ECD: ECDH10B_1713(rspB)
EBW: BWG_1394(rspB)
ECOK: ECMDS42_1250(rspB)
ECOC: C3026_09110
EOI: ECO111_2047(rspB)
EOJ: ECO26_2282(rspB)
EOH: ECO103_1719(rspB)
ECOO: ECRM13514_2068(rspB)
ECOH: ECRM13516_1973(rspB)
ESL: O3K_12720
ESO: O3O_12915
ESM: O3M_12680
ECG: E2348C_1664(rspB)
EOK: G2583_1974(rspB)
ELR: ECO55CA74_09690
ELH: ETEC_1614
ECW: EcE24377A_1787(rspB)
EUN: UMNK88_2034
ECP: ECP_1528
ENA: ECNA114_1625(rspB)
ECOS: EC958_1798(rspB)
ECV: APECO1_663(rspB)
ECOA: APECO78_11700
ECX: EcHS_A1653
ECM: EcSMS35_1620(rspB)
ECY: ECSE_1701
ECR: ECIAI1_1630(rspB)
ECQ: ECED1_1748(rspB)
EUM: ECUMN_1865(rspB)
ECT: ECIAI39_1478(rspB)
EOC: CE10_1850(rspB)
EBR: ECB_01549(rspB)
ECOB: C3029_12245
EBL: ECD_01549(rspB)
EBE: B21_01539(rspB)
EBD: ECBD_2066
ECI: UTI89_C1767(rspB)
EIH: ECOK1_1697(rspB)
ECZ: ECS88_1625(rspB)
ECC: c1970(rspB)
ELO: EC042_1727(rspB)
ELN: NRG857_07910
ESE: ECSF_1439
ECL: EcolC_2050
EKO: EKO11_2198
EKF: KO11_14855(rspB)
EAB: ECABU_c17760(rspB)
EDH: EcDH1_2063
EDJ: ECDH1ME8569_1523(rspB)
ELU: UM146_09270
ELW: ECW_m1745(rspB)
ELL: WFL_08545(rspB)
ELC: i14_1793(rspB)
ELD: i02_1793(rspB)
ELP: P12B_c1501(rspB)
ELF: LF82_2029(rspB)
ECOL: LY180_08230
ECOI: ECOPMV1_01675(tdh_1)
ECOJ: P423_08465
EFE: EFER_1526(rspB)
EAL: EAKF1_ch4474
EMA: C1192_04370 C1192_13960
ESZ: FEM44_22830
ERUY: OSH18_02625
STY: STY1555(rspB)
STT: t1427(rspB)
SEX: STBHUCCB_15150
SENT: TY21A_07225
STM: STM1506(rspB)
SEO: STM14_1819(rspB)
SEV: STMMW_15061
SEY: SL1344_1436(rspB)
SEM: STMDT12_C15200
SEJ: STMUK_1469(rspB)
SEB: STM474_1516(rspB)
SEF: UMN798_1569(rspB)
SETU: STU288_03845
SETC: CFSAN001921_09600
SENR: STMDT2_14331(rspB)
SEND: DT104_14761(rspB)
SENI: CY43_07670
SEEN: SE451236_13405
SPT: SPA1349(rspB)
SEK: SSPA1254
SPQ: SPAB_01804
SEI: SPC_2223(rspB)
SEC: SCH_1523(rspB)
SEH: SeHA_C1676
SHB: SU5_02117
SENH: CFSAN002069_01465
SEEH: SEEH1578_16750
SEE: SNSL254_A1617
SENN: SN31241_25770
SEW: SeSA_A1608
SEA: SeAg_B1666
SENS: Q786_07715
SEG: SG1614(rspB)
SEL: SPUL_1322(rspB)
SEGA: SPUCDC_1322(rspB)
SET: SEN1544(rspB)
SENA: AU38_07980
SENO: AU37_07980
SENV: AU39_07990
SENQ: AU40_08940
SENL: IY59_08175
SENJ: CFSAN001992_04050
SEEC: CFSAN002050_13930
SEEB: SEEB0189_011995
SEEP: I137_06125
SENB: BN855_15460
SENE: IA1_07450
SENC: SEET0819_14195
SES: SARI_01442
SBG: SBG_1333(rspB)
SBZ: A464_1526
SBV: N643_06380
SALZ: EOS98_11910
SHQ: A0259_11920
ENC: ECL_02182
ENL: A3UG_10210
ECLG: EC036_19820
ECLE: ECNIH2_10740
ECLN: ECNIH4_12535
ECLI: ECNIH5_09870
ECLX: LI66_10090
ECLY: LI62_10875
ECLZ: LI64_10240
ECLO: ENC_12060
EHM: AB284_14920
EXF: BFV63_10275
ECLA: ECNIH3_09880
ECLC: ECR091_09855
EAU: DI57_08715
ENO: ECENHK_10190
EEC: EcWSU1_02016(rspB)
ELG: BH714_06370
ECAN: CWI88_12345
ERN: BFV67_09710
ECLS: LI67_015620
ECHG: FY206_11615
ESH: C1N69_10415
EPT: HWQ17_02615
ENT: Ent638_1933
EAS: Entas_2007
ENX: NI40_010310
LNI: CWR52_01950
EBG: FAI37_19045
END: A4308_14825
ENZ: G0034_09940
ENS: HWQ15_18740
ENK: LOC22_20535
EHU: D5067_0012550
EMOR: L6Y89_10005
ENB: ELK40_10530
EQU: OM418_10035
EPU: QVH39_10460
CTU: CTU_22010(rspB)
KPN: KPN_03621
KPU: KP1_4933
KPM: KPHS_47610
KPP: A79E_0492
KPH: KPNIH24_05110
KPZ: KPNIH27_22745
KPV: KPNIH29_23655
KPW: KPNIH30_23980
KPY: KPNIH31_23095
KPG: KPNIH32_24860
KPC: KPNIH10_23690
KPQ: KPR0928_23210
KPT: VK055_3856
KPO: KPN2242_21180
KPR: KPR_4813(rspB)
KPJ: N559_0543
KPI: D364_18585
KPA: KPNJ1_00530
KPS: KPNJ2_00568
KPX: PMK1_01129(yjmD)
KPB: FH42_14475
KPNE: KU54_002605
KPNU: LI86_02610
KPNK: BN49_0499(rspB)
KVA: Kvar_0478
KPE: KPK_0500 KPK_B0038
KPK: A593_08300
KVD: KR75_05645
KVQ: SP68_12260
KOX: KOX_21515
KOE: A225_3174
KOY: J415_16070
KOM: HR38_19815
KMI: VW41_10435
KOK: KONIH1_15565
KOC: AB185_20330
KQU: AVR78_01960
EAE: EAE_18425
EAR: CCG30205
KQV: B8P98_02595
KLL: BJF97_15695
KLW: DA718_13560
KAR: LGL98_02535
KGR: JJJ10_13140
KPAS: LUW96_22265
KLC: K7H21_13000
KLM: BWI76_15890
REE: electrica_02379(yjmD)
ROR: RORB6_05610
RON: TE10_15635
RPLN: B1209_12270
RAO: DSD31_12085
RTG: NCTC13098_03452(tdh_2)
CRO: ROD_46081(rspB)
CKO: CKO_01574
CFD: CFNIH1_17600
CYO: CD187_12365
CFQ: C2U38_12375
CSED: JY391_11495
CAMA: F384_06810
CIF: AL515_11910
CFAR: CI104_12755
CIE: AN232_18230
CPAR: CUC49_07620
CTEL: GBC03_17795
CITZ: E4Z61_04815
CARS: E1B03_12980
CIX: M4I31_12025
CIB: HF677_012075
EBT: EBL_c22150(rspB)
PGE: LG71_16460
ESC: Entcl_2319
KLE: AO703_10625
KOR: AWR26_13650
KRD: A3780_10365
KOT: EH164_12150
KOB: HF650_10950
KIE: NCTC12125_01399(gutB_1)
KAS: KATP_21140
LAX: APT61_11715
LEI: C2U54_15695
LEE: DVA44_12640
LER: GNG29_10540
LEA: GNG26_10670
LEY: DVA43_07110
LAZ: A8A57_09915
LEF: LJPFL01_1980
LEW: DAI21_16285
BUF: D8682_03880
BAGE: BADSM9389_19720
BFT: MNO13_11615
YRE: HEC60_05855
SGOE: A8O29_011250
PDZ: HHA33_14175
METY: MRY16398_26790
IZH: FEM41_17000
SCOL: KFZ77_08940
SUPE: P0H77_11405
TOE: QMG90_11335
EBF: D782_2223
EBC: C2U52_22195
EBU: CUC76_18195
EBB: F652_2157(rspB)
PSTS: E05_03230
SMAC: SMDB11_2957(rspB)
SMW: SMWW4_v1c36750(rspB)
SPE: Spro_3564
SRR: SerAS9_3770
SRL: SOD_c34860(rspB)
SRY: M621_18945
SPLY: Q5A_018880(rspB)
SRS: SerAS12_3771
SRA: SerAS13_3771
SMAF: D781_3318
SLQ: M495_18345
SFW: WN53_00495
SFG: AV650_23210
SRZ: AXX16_1748
SERM: CLM71_17500
SQU: E4343_22890
SFJ: SAMEA4384070_3681(gutB_3)
SOF: NCTC11214_03100(gutB_2)
SURI: J0X03_05550
SRHZ: FO014_16720
SENP: KHA73_17940
RAH: Rahaq_1072
RACE: JHW33_22075
RAQ: Rahaq2_1143
RAA: Q7S_05130
ROX: BV494_00630
RVC: J9880_13185
RBON: QNM34_05465
RIU: I2123_07345
GQU: AWC35_18345
EAME: GXP68_05435
RBAD: H2866_02510
RCB: O1V66_00820
CARU: P0E69_14690
NIG: C1N62_12335
PROD: PCO85_04555
SERA: Ser39006_020895
SERQ: CWC46_20900
ECA: ECA0918(rspB)
PATR: EV46_04240
PATO: GZ59_08560
PCT: PC1_0803
PCC: PCC21_008290
PCV: BCS7_04110
PWA: Pecwa_1037
PPAR: A8F97_13750
PEC: W5S_0931
PWS: A7983_12485
PPOA: BJK05_20985
PBRA: B5S52_17545
PAQU: DMB82_0016155
PVZ: OA04_09230(rspB)
PPAV: LOZ86_05410
PQU: IG609_015890
PPOO: LW347_04330
PACB: M9782_06640
DDD: Dda3937_01655(rspB)
DZE: Dd1591_1269
DDQ: DDI_2839
DDA: Dd703_2636
BGJ: AWC36_14045
BNG: EH206_17950
BIZ: HC231_18880
SOD: Sant_0032
SLIG: GTU79_10315
EBI: EbC_29610
EPE: CI789_03895
ERWI: GN242_07010
ERP: LJN55_15355
ETO: RIN69_14960
EGE: EM595_2411(rspB)
PVA: Pvag_2005(rspB)
PAGG: AL522_16915
PAO: Pat9b_2614
KLN: LH22_09450
PANP: PSNIH2_04965
PAGC: BEE12_00625
PALH: B1H58_14375
PANS: FCN45_12650
PEY: EE896_06650
PDIS: D8B20_11215
PJI: KTJ90_06435
PANO: OJ965_08915
KPIE: N5580_05975
PALF: K6R05_06535
PGZ: C2E15_13730
PCD: C2E16_13830
MINT: C7M51_01908(rspB)
MTHI: C7M52_00899(rspB)
MHAN: K6958_13330
PHEI: NCTC12003_03944(gutB_4)
PRQ: CYG50_16300
PHAG: PZ638_20665
HAV: AT03_16150
HPAR: AL518_10565
OPO: DSM2777_19295
LPV: HYN51_08265
PRAG: EKN56_18700
PFQ: QQ39_01485
LRI: NCTC12151_00325(gutB_1)
MVI: X808_19840
ASU: Asuc_0369
AGK: NYR60_04205
VSR: Vspart_03580(yjmD)
VOS: KNV97_08860
POR: APT59_12555
PLUL: FOB45_15545
PBA: PSEBR_a2372
PBC: CD58_17075
PPSY: AOC04_01185
PPSH: G5J76_07200
PVK: EPZ47_17235
PBZ: GN234_00765
PALV: KSS97_16655
PCAS: LOY40_15925
PPAO: K3169_14810
CSA: Csal_2975
HEL: HELO_1147(rspB)
HAK: KO116_02821
HAM: HALO3082
HHU: AR456_15715
HAXI: HAALTHF_10510n
HSV: HNO53_06380
HPRO: LMS44_07990
HBH: E4T21_15445
HALF: QEN58_06640
HHAO: QWG60_01090
HASO: B2G49_04615
HNP: SR894_06795
HTT: HZS52_19960
HTX: EKK97_06760
MMW: Mmwyl1_0038
MPC: Mar181_0029
MARD: IBG28_00195
MFOI: JSY38_09480
MRHI: KDW99_00180
MARS: A8C75_12295
GAP: GAPWK_0541
AMAH: DLM_0674
AQS: DKK66_01835
REH: H16_A1934(tdh)
CUH: BJN34_10215
CTI: RALTA_A2841(rspB)
COX: E0W60_25915
CNAN: A2G96_20760
BMA: BMAA0765
BMV: BMASAVP1_0584
BML: BMA10229_0695
BMN: BMA10247_A1649
BMAL: DM55_4675
BMAE: DM78_3382
BMAQ: DM76_3628
BMAI: DM57_11775
BMAF: DM51_4465
BMAZ: BM44_4668
BMAB: BM45_3190
BPS: BPSS1478a(rspB)
BPM: BURPS1710b_A0512(rspB)
BPL: BURPS1106A_A2002(rspB)
BPD: BURPS668_A2097
BPSE: BDL_4787
BPSM: BBQ_4669
BPSU: BBN_4924
BPSD: BBX_3949
BPZ: BP1026B_II1569(rspB)
BPQ: BPC006_II1983
BPK: BBK_4090
BPSH: DR55_3795
BPSA: BBU_4557
BPSO: X996_3582
BUT: X994_5638
BUU: WS70_24985
BSAV: WS86_26535
BAM: Bamb_4598
BAC: BamMC406_5131
BCT: GEM_3242
BPYR: ABD05_23395
BTEI: WS51_09190
BANN: JFN94_16460
BGL: bglu_2g01920
BGU: KS03_3459
BGO: BM43_6943
BGP: BGL_2c01570(rspB)
BPLA: bpln_2g01550
BURK: DM992_23805
PBON: QS306_11155
HYF: DTO96_101051
ARUI: G6M88_15670
AVI: Avi_7076
RJG: CCGE525_31380
RLS: HB780_08025
RTU: PR017_18800
ARA: Arad_8888
NEN: NCHU2750_49590(rspB)
BBT: BBta_2119
AOL: S58_57410
BRO: BRAD285_5486(rspB)
MNO: Mnod_0981
MEE: DA075_30595
JAV: OXU80_21710
PGA: PGA1_c07730
PPIC: PhaeoP14_00694
PHQ: D1820_16940
LEJ: ETW24_02315
LAQU: R2C4_00640
PSAP: JHX88_10670
RCV: PFY06_17860
AZL: AZL_e02200(rspB)
ALI: AZOLI_p50105(rspB)
ATI: AL072_28950
AHU: A6A40_13165
AZM: DM194_25700
AOZ: HUE56_22520
AZS: E6C72_29640
DTI: Desti_0094
PSON: JI735_33985
PPSC: EHS13_34980
PBK: Back11_43850(adh_4)
PSPN: L1F29_29725
PKP: SK3146_05959(gatD)
COHN: KCTCHS21_33010(adh_4)
LFE: LAF_1827
LFF: LBFF_2016
LOR: AYI71_09545
LPAR: FAM21731_01161
LKF: DNL43_04210
OOE: OEOE_1707
AGAT: RWV98_13120
STHR: BXT84_13465
BYL: A4V09_03455
BPRO: PMF13cell1_04771(yjmD_5)
LACY: A4V08_34390
ARF: AR1Y2_0264
ACAC: EYQ97_15370
HALS: D7D81_03675
CGY: CGLY_14840
ROP: ROP_21300
ROA: Pd630_LPD06623
RTM: G4H71_11900
SVL: Strvi_5395
SFK: KY5_0710
SKA: CP970_06645 CP970_39445
SBAT: G4Z16_18465
SROI: IAG44_03100
MHOS: CXR34_05700
MPRT: ET475_04335
SALC: C2138_11905 C2138_12180
ARQ: BWQ92_13445
ACRY: AC20117_06585
ARTP: E5206_05330
ACIR: OG979_35865
NOW: GBF35_20975
AAB: A4R43_26040
AACD: LWP59_35755
APRE: CNX65_22305
AMI: Amir_4479
ACTA: C1701_23190
PMAD: BAY61_18785 BAY61_24675
MTUA: CSH63_05710
AFS: AFR_10705
CAP: CLDAP_16530
TSC: TSC_c17790
THC: TCCBUS3UF1_15730
TOS: Theos_1066
TBC: A0O31_00441
MHD: Marky_0606
STA: STHERM_c06020
STQ: Spith_0616
DRC: G0Q07_09300
MCOS: GM418_31165
ANF: AQPE_4735
STAE: HNV11_16735
SFOL: H3H32_09450
ALAM: RT761_01142(rspB)
 » show all
Reference
1  [PMID:6993236]
  Authors
Cooper RA
  Title
The pathway for L-gulonate catabolism in Escherichia coli K-12 and Salmonella typhimurium LT-2.
  Journal
FEBS Lett 115:63-7 (1980)
DOI:10.1016/0014-5793(80)80727-7
Reference
2  [PMID:25145794]
  Authors
Wichelecki DJ, Vendiola JA, Jones AM, Al-Obaidi N, Almo SC, Gerlt JA
  Title
Investigating the physiological roles of low-efficiency D-mannonate and D-gluconate dehydratases in the enolase superfamily: pathways for the catabolism of L-gulonate and L-idonate.
  Journal
Biochemistry 53:5692-9 (2014)
DOI:10.1021/bi500837w
  Sequence
[csa:Csal_2975]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.380
IUBMB Enzyme Nomenclature: 1.1.1.380
ExPASy - ENZYME nomenclature database: 1.1.1.380
BRENDA, the Enzyme Database: 1.1.1.380

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (808)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (542)   
   KEGG MGENES (89)   
   RefGene (176)   
Protein sequence (22)   
   UniProt (22)   
DNA sequence (40)   
   GenBank (20)   
   EMBL (20)   
All databases (881)   

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