Entry
Name
L-serine 3-dehydrogenase (NAD+);
NAD+-dependent L-serine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-serine:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-serine + NAD+ = 2-aminoacetaldehyde + CO2 + NADH + H+ (overall reaction) [RN:
R10986 ];
(1a) L-serine + NAD+ = 2-aminomalonate semialdehyde + NADH + H+ [RN:
R10985 ];
(1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous) [RN:
R06830 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC
1.1.1.103 , L-threonine 3-dehydrogenase). The enzyme has only very low activity with NADP+ [cf. EC
1.1.1.276 , serine 3-dehydrogenase (NADP+)].
History
EC 1.1.1.387 created 2015
Orthology
K19711 L-serine 3-dehydrogenase (NAD+)
Genes
PCQ : PcP3B5_38910(mmsB_2)
» show all
Taxonomy
Reference
Authors
Tchigvintsev A, Singer A, Brown G, Flick R, Evdokimova E, Tan K, Gonzalez CF, Savchenko A, Yakunin AF
Title
Biochemical and structural studies of uncharacterized protein PA0743 from Pseudomonas aeruginosa revealed NAD+-dependent L-serine dehydrogenase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.387