KEGG ENZYME: 1.1.1.388

ENZYME: 1.1.1.388

Entry

EC 1.1.1.388                Enzyme

Name

glucose-6-phosphate dehydrogenase (NAD+);
Glc6PDH;
azf (gene name);
archaeal zwischenferment

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-glucose-6-phosphate:NAD+ 1-oxidoreductase

Reaction(IUBMB)

D-glucose 6-phosphate + NAD+ = 6-phospho-D-glucono-1,5-lactone + NADH + H+ [RN:R10520]

Reaction(KEGG)

R10520 > R10907

Substrate

D-glucose 6-phosphate [CPD:C00092];
NAD+ [CPD:C00003]

Product

6-phospho-D-glucono-1,5-lactone [CPD:C01236];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme catalyses a step of the pentose phosphate pathway. The enzyme from the archaeon Haloferax volcanii is specific for NAD+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.49, glucose-6-phosphate dehydrogenase (NADP+).

History

EC 1.1.1.388 created 2015

Pathway

ec00030

Pentose phosphate pathway

Orthology

K19243

NAD+ dependent glucose-6-phosphate dehydrogenase

Genes

SMAC:

SMDB11_4230

SMW:	SMWW4_v1c01330

SPE:

Spro_0125

SRR:	SerAS9_0085

SRL:	SOD_c00800

SRY:	M621_00395

SPLY:

Q5A_000425(udh)

SRS:	SerAS12_0085

SRA:	SerAS13_0084

SMAF:

D781_0092

SLQ:	M495_00425

SERF:

L085_05040

SERS:

SERRSCBI_00530

SFW:	WN53_08960

SFG:	AV650_01965

SRZ:	AXX16_0430

SERM:

CLM71_00560

SQU:	E4343_15670

SFJ:	SAMEA4384070_0088

SSUR:

ATE40_021335

SURI:

J0X03_23415

SRHZ:

FO014_09445

SENP:

KHA73_22670

SNEM:

NLX84_00365

SNEV:

OI978_06010

SFO:	Z042_12665

GQU:	AWC35_10960

VNI:	VIBNI_B0433

VSH:	BSZ05_17150

MMEO:

OOT43_15260

EMP:	EZMO1_3099

LABP:

FJ695_05645

RUA:	D1823_00645

PHQ:	D1820_15470

BLI:	BL00020(ytbQ)

BLD:	BLi03170(ytbQ)

BLH:	BaLi_c32420(ytbQ)

BSON:

S101395_01332

BPU:

BPUM_2667

BPUM:

BW16_14380

BPUS:

UP12_13645

BXI:	BK049_13705

BALT:

CFN77_14320

BSAF:

BSL056_15045

BACW:

QR42_13450

OIH:

OB2094

JEP:	BW721_01640

JDA:	BW727_101137(udh)

JAR:	G7057_00785

AGRO:

JSQ78_04010

BFA:	Bfae_19740

BRX:	BH708_05895

BRV:	CFK39_02265

BGG:	CFK41_06745

BRZ:	CFK38_09045

BSAU:

DWV08_07345

BRR:	C1N80_08935

BRHA:

NLU66_09695

ARS:	ADJ73_06060

JLI:	EXU32_08155

JME:	EEW87_000815

JCR:	O9K63_03330

SERW:

FY030_05825

ORN:	DV701_11445

GEZ:	FE251_10790

RSUA:

LQF12_03265

MICG:

GJV80_12200

TFL:	RPIT_03130

TEZ:	BKM78_12175

TLA:	TLA_TLA_02453(udh_2)

BRT:	J4N02_06995

VER:	HUT12_13150

KBS:	EPA93_05700

TRO:

trd_1948

MTAR:

DF168_00247(udh_1)

PLON:

Pla110_18890(fcl_3)

HBS:	IPV69_22805

HAL:

VNG_0128C

HSL:

OE_1209F

HANR:

LJ422_00595

HDL:	HALDL1_04035

HHB:

Hhub_1317

HAGS:

JT689_01935

HABO:

JRZ79_00460

HNO:	LT974_01500

HLU:	LT972_12330

HALH:

HTSR_1773

HHSR:

HSR6_1839

HSU:	HLASF_0479

HSF:	HLASA_0476

HAHS:

HSRCO_0778(wcaG)

SALR:

FQU85_02990

HALR:

EFA46_005210 EFA46_010660 EFA46_010735

HJE:	HacjB3_14685

HDO:	MUK72_03965

HALX:

M0R89_08310

HAXZ:

M0R88_08495

HAYC:

NGM10_00575 NGM10_07300

HAXY:

NGM07_14215

SALI:

L593_05140 L593_11535

SAIM:

K0C01_00340

HARA:

AArcS_2737(wcaG11)

HMA:

rrnAC2305

HHI:

HAH_2759

HHN:	HISP_14025

HAB:	SG26_03090 SG26_06305

HTA:	BVU17_13435

HALJ:

G9465_22030 G9465_23975

HSIN:

KDQ40_15555

NPH:	NP_0308A(azf)

NMO:

Nmlp_1075

NHO:	HWV23_07375

NSAL:

HWV07_10755

HMU:

Hmuk_0576

HALZ:

E5139_06035

HALL:

LC1Hm_3107

HAZP:

GBQ70_06030

HALI:

BV210_06955

HSN:	DV733_11575

HDS:	HSR122_1890(wcaG3)

HRR:	HZS55_00310 HZS55_21660

HPEL:

HZS54_00365 HZS54_10485 HZS54_25135

HLT:	I7X12_13175 I7X12_14960

HARC:

HARCEL1_00695

SSAI:

N0B31_17210

HAAD:

MW046_08820

HWA:	HQ_1135A(azf)

HWC:	Hqrw_1170(azf)

HVO:	HVO_0511(azf) HVO_B0096

HME:

HFX_0485

HGI:	ABY42_02395 ABY42_15930 ABY42_18635

HALE:

G3A49_02635 G3A49_06695

HLS:	KU306_07145

HLN:	SVXHx_0470(azf) SVXHx_3376(azf)

HBO:	Hbor_27280

HAQ:	DU484_01385 DU484_06630

HAJ:	DU500_01935 DU500_06900

HAER:

DU502_17440

HRA:	EI982_13605

HLM:	DV707_13470

HALM:

FCF25_06995 FCF25_09350

HLA:	Hlac_0117 Hlac_2457

HALP:

DOS48_00600

HALB:

EKH57_11815

HEZZ:

EO776_00480

HALQ:

Hrr1229_006340

HSS:	J7656_00745

HSAI:

HPS36_06255

HAZZ:

KI388_14110

SRUB:

C2R22_02330 C2R22_03520 C2R22_19640 C2R22_24195

HAE:	halTADL_0298

HALN:

B4589_010180 B4589_012900

HALG:

HUG10_05530 HUG10_15360 HUG10_15910 HUG10_17945 HUG10_20285

HALU:

HUG12_18245

HMP:	K6T50_13120

HRE:	K6T36_13035

HRM:	K6T25_03630

HACB:

Hbl1158_04965

HDF:	AArcSl_0115 AArcSl_0416

HAAA:

AArcCO_0262(wcaG)

HAH:	Halar_2838 Halar_3481

HTU:	Htur_0435 Htur_0833 Htur_4212 Htur_4433

HSAL:

JMJ58_07010 JMJ58_23600

HAKZ:

J0X25_08735

NMG:	Nmag_2247(azf)

HXA:	Halxa_0384 Halxa_1805

NAT:

NJ7G_4277

NPE:	Natpe_3416

NVR:	FEJ81_16400 FEJ81_22085

NPL:	FGF80_15460

NAY:	HYG81_12865 HYG81_23160

HALY:

HYG82_13630 HYG82_18190

HJT:	DVR14_07215

HLO:	J0X27_16360

NGE:	Natgr_1320

HRU:	Halru_2600

SAWL:

NGM29_04355

HALV:

NGM15_13960

NOU:	Natoc_0279

HLR:	HALLA_02775 HALLA_04445 HALLA_04630 HALLA_06030

HLC:	CHINAEXTREME02945

NAJ:	B1756_06410

NAG:	AArcMg_0155

NAN:	AArc1_0157

NARA:

QQ977_06765(azf)

NBG:	DV706_08395

NAS:	GCU68_03710

HDA:	BB347_12925

NCON:

LC1Nh_0694

» show all

Reference

1 [PMID:25836736]

Authors

Pickl A, Schonheit P

Title

The oxidative pentose phosphate pathway in the haloarchaeon Haloferax volcanii involves a novel type of glucose-6-phosphate dehydrogenase - The archaeal Zwischenferment.

Journal

FEBS Lett 589:1105-11 (2015)
DOI:10.1016/j.febslet.2015.03.026

Sequence

[hvo:HVO_0511]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.388

IUBMB Enzyme Nomenclature:

1.1.1.388

ExPASy - ENZYME nomenclature database:

1.1.1.388

BRENDA, the Enzyme Database:

1.1.1.388

DBGET integrated database retrieval system