KEGG ENZYME: 1.1.1.393

ENZYME: 1.1.1.393

Entry

EC 1.1.1.393                Enzyme

Name

3beta-hydroxycholanate 3-dehydrogenase (NADP+);
3beta-hydroxysteroid dehydrogenase (ambiguous)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

isolithocholate:NADP+ 3-oxidoreductase

Reaction(IUBMB)

isolithocholate + NADP+ = 3-oxo-5beta-cholan-24-oate + NADPH + H+ [RN:R11146]

Reaction(KEGG)

R11146

Substrate

isolithocholate [CPD:C17658];
NADP+ [CPD:C00006]

Product

3-oxo-5beta-cholan-24-oate [CPD:C03070];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

This bacterial enzyme is involved, along with EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391, 3beta-hydroxycholanate 3-dehydrogenase (NAD+).

History

EC 1.1.1.393 created 2016

Pathway

ec00121

Secondary bile acid biosynthesis

Orthology

K22607

3beta-hydroxycholanate 3-dehydrogenase (NADP+)

Reference

1 [PMID:3458705]

Authors

Akao T, Akao T, Hattori M, Namba T, Kobashi K