Entry
Name
beta-methylindole-3-pyruvate reductase;
ind2 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate:NAD+ oxidoreductase
Reaction(IUBMB)
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+ = (R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+ [RN:
R11336 ]
Reaction(KEGG)
Substrate
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate [CPD:
C21288 ];
NAD+ [CPD:
C00003 ]
Product
Comment
The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan---tRNA ligase (EC
6.1.1.2 ).
History
EC 1.1.1.397 created 2016
Orthology
K20939 beta-methylindole-3-pyruvate reductase
Reference
Authors
Du YL, Alkhalaf LM, Ryan KS
Title
In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.397