KEGG   ENZYME: 1.1.1.397
Entry
EC 1.1.1.397                Enzyme                                 
Name
beta-methylindole-3-pyruvate reductase;
ind2 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate:NAD+ oxidoreductase
Reaction(IUBMB)
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+ = (R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+ [RN:R11336]
Reaction(KEGG)
R11336
Substrate
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate [CPD:C21288];
NAD+ [CPD:C00003]
Product
(R)-3-(indol-3-yl)-2-oxobutanoate [CPD:C21289];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan---tRNA ligase (EC 6.1.1.2).
History
EC 1.1.1.397 created 2016
Orthology
K20939  beta-methylindole-3-pyruvate reductase
Reference
1  [PMID:25730866]
  Authors
Du YL, Alkhalaf LM, Ryan KS
  Title
In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.
  Journal
Proc Natl Acad Sci U S A 112:2717-22 (2015)
DOI:10.1073/pnas.1419964112
  Sequence
[ag:AJT38683]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.397
IUBMB Enzyme Nomenclature: 1.1.1.397
ExPASy - ENZYME nomenclature database: 1.1.1.397
BRENDA, the Enzyme Database: 1.1.1.397

  All links  
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
All databases (11)   

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