KEGG   ENZYME: 1.1.1.400
Entry
EC 1.1.1.400                Enzyme                                 
Name
2-methyl-1,2-propanediol dehydrogenase;
mpdB (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-methylpropane-1,2-diol:NAD+ 1-oxidoreductase
Reaction(IUBMB)
2-methylpropane-1,2-diol + NAD+ = 2-hydroxy-2-methylpropanal + NADH + H+ [RN:R11338]
Reaction(KEGG)
R11338
Substrate
2-methylpropane-1,2-diol [CPD:C21290];
NAD+ [CPD:C00003]
Product
2-hydroxy-2-methylpropanal [CPD:C21291];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant.
History
EC 1.1.1.400 created 2016
Orthology
K20927  2-methyl-1,2-propanediol dehydrogenase
Genes
KAI: K32_33580
AALM: LUX29_04385
AHT: ANTHELSMS3_05160
PNP: IJ22_15610
MDX: BTO20_34765
MVQ: MYVA_3535
MMAT: MMAGJ_18710
HOM: OF852_11210
PUE: FV140_21035
BSD: BLASA_1405(mpdB)
AACD: LWP59_25520
PSEA: WY02_10395
PSEE: FRP1_03830
PSEQ: AD006_11490
PECQ: AD017_19320
PHH: AFB00_04315
RRD: RradSPS_2609
RMAR: GBA65_01885
 » show all
Reference
1  [PMID:16622053]
  Authors
Lopes Ferreira N, Labbe D, Monot F, Fayolle-Guichard F, Greer CW
  Title
Genes involved in the methyl tert-butyl ether (MTBE) metabolic pathway of Mycobacterium austroafricanum IFP 2012.
  Journal
Microbiology 152:1361-74 (2006)
DOI:10.1099/mic.0.28585-0
  Sequence
[ag:AAZ78237]
Reference
2  [PMID:25576605]
  Authors
Kottegoda S, Waligora E, Hyman M
  Title
Metabolism of 2-methylpropene (isobutylene) by the aerobic bacterium Mycobacterium sp. strain ELW1.
  Journal
Appl Environ Microbiol 81:1966-76 (2015)
DOI:10.1128/AEM.03103-14
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.400
IUBMB Enzyme Nomenclature: 1.1.1.400
ExPASy - ENZYME nomenclature database: 1.1.1.400
BRENDA, the Enzyme Database: 1.1.1.400

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Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (19)   
   KEGG MGENES (9)   
Protein sequence (24)   
   UniProt (23)   
   SWISS-PROT (1)   
DNA sequence (34)   
   GenBank (18)   
   EMBL (16)   
Protein domain (4)   
   InterPro (4)   
All databases (98)   

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