KEGG ENZYME: 1.1.1.403

ENZYME: 1.1.1.403

Entry

EC 1.1.1.403                Enzyme

Name

D-threitol dehydrogenase (NAD+);
dthD (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-threitol:NAD+ oxidoreductase

Reaction(IUBMB)

D-threitol + NAD+ = D-erythrulose + NADH + H+ [RN:R11342]

Reaction(KEGG)

R11342

Substrate

D-threitol [CPD:C16884];
NAD+ [CPD:C00003]

Product

D-erythrulose [CPD:C02022];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme, characterized from the bacterium Mycobacterium smegmatis, participates in the degradation of D-threitol.

History

EC 1.1.1.403 created 2016

Orthology

K20900

D-threitol dehydrogenase (NAD+)

Genes

MMC:

Mmcs_2791

MKM:

Mkms_2835

MJL:

Mjls_2818

MSM:	MSMEG_3607

MSG:	MSMEI_3523

MSB:	LJ00_17940

MSN:	LI99_17945

MSH:	LI98_17950

MCB:	Mycch_5122

MPHL:

MPHLCCUG_02600(ped_2)

MVQ:

MYVA_1610

MLL:	B1R94_01855

MAUU:

NCTC10437_00317(fabG3_1)

MMAG:

MMAD_30180(dthD)

MTY:	MTOK_24860(dthD_2)

MPSC:

MPSYJ_10910(dthD)

MARZ:

MARA_09600(dthD)

MMAT:

MMAGJ_66380(dthD)

MSEI:

MSEDJ_42120(dthD)

MMON:

EWR22_14810

MGO:	AFA91_21835

MRF:	MJO55_26670

MGRO:

FZ046_20035

MCAB:

HXZ27_16685

PRY:	Prubr_55200(dthD_1)

» show all

Reference

1 [PMID:26560079]

Authors

Huang H, Carter MS, Vetting MW, Al-Obaidi N, Patskovsky Y, Almo SC, Gerlt JA

Title

A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis.

Journal

J Am Chem Soc 137:14570-3 (2015)
DOI:10.1021/jacs.5b08968

Sequence

[msm:MSMEG_3607]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.403

IUBMB Enzyme Nomenclature:

1.1.1.403

ExPASy - ENZYME nomenclature database:

1.1.1.403

BRENDA, the Enzyme Database:

1.1.1.403

DBGET integrated database retrieval system