KEGG ENZYME: 1.1.1.405

ENZYME: 1.1.1.405

Entry

EC 1.1.1.405                Enzyme

Name

ribitol-5-phosphate 2-dehydrogenase (NADP+);
acs1 (gene name);
bcs1 (gene name);
tarJ (gene name);
ribulose-5-phosphate reductase;
ribulose-5-P reductase;
D-ribulose 5-phosphate reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-ribitol-5-phosphate:NADP+ 2-oxidoreductase

Reaction(IUBMB)

D-ribitol 5-phosphate + NADP+ = D-ribulose 5-phosphate + NADPH + H+ [RN:R01525]

Reaction(KEGG)

R01525

Substrate

D-ribitol 5-phosphate [CPD:C01068];
NADP+ [CPD:C00006]

Product

D-ribulose 5-phosphate [CPD:C00199];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Requires Zn2+. The enzyme, characterized in bacteria, is specific for NADP. It is part of the synthesis pathway of CDP-ribitol. In Haemophilus influenzae it is part of a multifunctional enzyme also catalysing EC 2.7.7.40, D-ribitol-5-phosphate cytidylyltransferase. cf. EC 1.1.1.137, ribitol-5-phosphate 2-dehydrogenase.

History

EC 1.1.1.405 created 2017

Pathway

ec00040

Pentose and glucuronate interconversions

ec01100

Metabolic pathways

Orthology

K05352

ribitol-5-phosphate 2-dehydrogenase (NADP+)

K21681

ribitol-5-phosphate 2-dehydrogenase (NADP+) / D-ribitol-5-phosphate cytidylyltransferase

Genes

ECOS:

EC958_3340

KCO:	BWI95_19355

KLU:	K7B04_05685

LEY:	DVA43_14810

HIU:	HIB_11690(bcs1') HIB_11840(bcs1')

AEU:	ACEE_10835

ALIG:

NCTC10568_01939(ispD_2)

BTRA:

F544_4610

PAET:

NCTC13378_01387

TBV:	H9L17_00500

PCQ:	PcP3B5_16180(ispD1) PcP3B5_47970(ispD2)

PBAU:

OS670_05290

ALJ:	G8D99_14930

ACIU:

A3K93_11085

SINI:

GT972_07520

WBO:	MIS45_03430

CKE:	B5M06_15305

HYL:	LPB072_04595

HPSE:

HPF_20235(ispD2)

SDO:	SD1155_05535

ZMO:

ZMO0353

ZMN:

Za10_0885

ZMM:

Zmob_0895

ZMB:

ZZ6_0893

ZMI:

ZCP4_0917

ZMC:	A265_00908(ispD2)

ZMR:	A254_00908(ispD2)

ZMP:	Zymop_0844

HWI:	A0Z60_06675

CCQ:	N149_1385(ispD)

ABL:	A7H1H_2199

ATHR:

ATH_1037

NAM:

NAMH_1606

CPAF:

C6V80_08920(ispD)

PPRF:

DPRO_1984(bcs)

PSEL:

GM415_05370(ispD)

BSL:

A7A1_1142

BSY:	I653_17450

BSUS:

Q433_19600

BSX:	C663_3469(tarJ)

BSS:	BSUW23_17570(tarJ)

BST:	GYO_3934(tarJ)

BIT:	BIS30_07540

BHT:	DIC78_13180

BMOJ:

HC660_34680(gutB)

BTEQ:

G4P54_18375

BIQ:	AN935_18030

BFD:	NCTC4823_03510(tarJ)

BRY:	M0696_18135

BJS:

MY9_3631

BACY:

QF06_16295

OJD:	NP439_01380

HNZ:	P9989_17850

TAID:

KS242_14085

VIR:	X953_16975

FPN:	ABE65_019035

FEC:	QNH15_21945

APAK:

AP3564_02710

ACOP:

RI196_14780

PRD:	F7984_17520

GAJ:	MY490_02515

FAF:	OE104_14480

PUK:	PU629_01925

SAU:	SA0242 SA0246

SAV:	SAV0252 SAV0256

SAW:	SAHV_0251 SAHV_0255

SAH:	SaurJH1_0243 SaurJH1_0247

SAJ:	SaurJH9_0237 SaurJH9_0241

SAM:	MW0228 MW0232

SAS:	SAS0228 SAS0233

SAR:	SAR0247 SAR0253

SAC:	SACOL0237 SACOL0241

SAX:	USA300HOU_0263 USA300HOU_0267

SAA:	SAUSA300_0246 SAUSA300_0250

SAO:	SAOUHSC_00221 SAOUHSC_00226

SAE:	NWMN_0186 NWMN_0190

SAD:	SAAV_0220 SAAV_0224

SUU:	M013TW_0233 M013TW_0237

SUV:	SAVC_01000 SAVC_01020

SUE:	SAOV_0191 SAOV_0195

SUJ:	SAA6159_00229 SAA6159_00233

SUK:	SAA6008_00225 SAA6008_00230

SUC:	ECTR2_213 ECTR2_217

SUT:	SAT0131_00244 SAT0131_00249

SUQ:	HMPREF0772_10246 HMPREF0772_10251

SUZ:	MS7_0240 MS7_0246

SUD:	ST398NM01_0264 ST398NM01_0269

SUX:	SAEMRSA15_02110 SAEMRSA15_02150

SUW:	SATW20_02540(tarJ') SATW20_02580(tarJ)

SUG:	SAPIG0264 SAPIG0269

SUF:	SARLGA251_02160(tarJ') SARLGA251_02200(tarJ)

SAUA:

SAAG_00733 SAAG_00737

SAUE:

RSAU_000196 RSAU_000200

SAUN:

SAKOR_00229 SAKOR_00235

SAUS:

SA40_0210 SA40_0214

SAUU:

SA957_0225 SA957_0229

SAUG:

SA268_0222 SA268_0226

SAUZ:

SAZ172_0254 SAZ172_0259

SAUT:

SAI1T1_2001930 SAI1T1_2001970

SAUJ:

SAI2T2_1001930 SAI2T2_1001970

SAUK:

SAI3T3_1001930 SAI3T3_1001970

SAUQ:

SAI4T8_1001930 SAI4T8_1001970

SAUV:

SAI7S6_1001930 SAI7S6_1001970

SAUW:

SAI5S5_1001920 SAI5S5_1001960

SAUX:

SAI6T6_1001930 SAI6T6_1001970

SAUY:

SAI8T7_1001930 SAI8T7_1001970

SAUF:

X998_0228 X998_0232

SAB:

SAB0195

SUY:	SA2981_0252 SA2981_0256

SAUB:

C248_0239 C248_0244

SAUM:

BN843_2510 BN843_2550

SAUC:

CA347_259 CA347_263

SAUR:

SABB_01596(tarJ) SABB_01601

SAUI:

AZ30_01265 AZ30_01285

SAUD:

CH52_04445 CH52_04465

SAMS:

NI36_01160 NI36_01180

SUH:	SAMSHR1132_02200 SAMSHR1132_02240

SER:

SERP0197

SEP:

SE_0320

SEPP:

SEB_00242

SEPS:

DP17_1630

SSP:	SSP0355 SSP2179

SWA:	A284_10560

SPAS:

STP1_1638

SXY:	BE24_00380 BE24_10205

SXL:	SXYLSMQ121_0383 SXYLSMQ121_2179

SXO:	SXYL_00386 SXYL_02332

SSCH:

LH95_01795

SEQO:

SE1039_21960

SCV:	A4G25_09300

SPET:

CEP67_06500

SKL:	C7J89_03590

SCAR:

DWB96_11770

SARL:

SAP2_04710(tarJ) SAP2_22340(tdh)

SSH:	NCTC13712_00198(gutB_3) NCTC13712_00202(gutB_4)

SSIM:

SAMEA4384339_0089(gutB_2) SAMEA4384339_0503

SLLO:

ISP08_02335

SPSD:

JMB28_02425 JMB28_11805 JMB28_13570

SEDA:

MNY58_01950 MNY58_11710

SCAQ:

QMO72_02025

SROT:

ML435_01075 ML435_01095

STAP:

AOB58_2215

SFF:	FOB90_06005

SSTE:

SAMEA4384403_1040

NMY:	CJ229_008690

LMO:

lmo1087

LMN:	LM5578_1170

LMY:	LM5923_1124

LMT:	LMRG_00549

LMOC:

LMOSLCC5850_1093

LMOE:

BN418_1305

LMOB:

BN419_1302

LMOD:

LMON_1097

LMOW:

AX10_14015

LMOQ:

LM6179_01407

LMR:	LMR479A_1115(tarJ)

LMOM:

IJ09_04850

LMF:	LMOf2365_1101

LMC:	Lm4b_01100

LMOG:

BN389_11140(tarJ)

LMP:

MUO_05675

LMOL:

LMOL312_1081

LMOJ:

LM220_05537

LMOZ:

LM1816_14227

LMOX:

AX24_02825

LMH:	LMHCC_1546

LMQ:

LMM7_1111

LML:	lmo4a_1089

LMG:	LMKG_01833

LMS:

LMLG_2570

LMJ:	LMOG_00631

LMW:	LMOSLCC2755_1085

LMX:	LMOSLCC2372_1101

LMZ:	LMOSLCC2482_1131

LMON:

LMOSLCC2376_1052

LMOS:

LMOSLCC7179_1068

LMOO:

LMOSLCC2378_1098

LMOY:

LMOSLCC2479_1101

LMOT:

LMOSLCC2540_1084

LMOA:

LMOATCC19117_1103

LMOK:

CQ02_05635

LMV:	Y193_10330

LIN:

lin1072

LWE:

lwe1062

LSG:

lse_0977

LIV:

LIV_1028

LII:	JL52_05465

LIW:	AX25_05555

LIA:	JL58_05685

LIO:	JL53_06175

LWI:	UE46_11740

LGZ:	NCTC10812_01810(idnD)

LMAR:

LAX80_005000

LNW:	OTR81_10225

ESI:

Exig_0190

EAN:	Eab7_0182(tarJ)

EXU:	ESP131_03400

EACE:

KKI46_01220

GOT:	AXE85_01085

GMO:	NCTC11323_00090(idnD)

GEQ:	CG018_02855

GSA:	FOC50_03555

GHA:	NCTC10459_00071 NCTC10459_00103

BCHS:

JNE38_25530

PNP:	IJ22_48470

POW:	IJ21_39000

PSPN:

L1F29_33665

PAUN:

MJA45_28035

PKP:	SK3146_01499(yjjN_1)

KUR:	ASO14_2501

NTR:	B0W44_10465

LLD:	P620_01405

SPN:

SP_1270

SPD:

SPD_1126

SPR:

spr1148

SPW:

SPCG_1234

SJJ:

SPJ_1184

SNV:	SPNINV200_11590

SPX:

SPG_1164

SNT:

SPT_0958

SND:

MYY_0970

SPNN:

T308_04435

SNE:	SPN23F11640

SPV:

SPH_1386

SNC:	HMPREF0837_11231

SNM:	SP70585_1333

SPP:

SPP_1308

SNI:	INV104_10920

SPNG:

HMPREF1038_01273

SNB:	SP670_1005

SNP:

SPAP_1295

SNX:	SPNOXC11350

SNU:	SPNA45_00914

SPNE:

SPN034156_02230

SPNU:

SPN034183_11350

SPNM:

SPN994038_11240

SPNO:

SPN994039_11250

SMB:	smi_1227(tarJ)

SOR:	SOR_1098(tarJ)

STD:	SPPN_06310

SIG:	N596_06770

SIP:	N597_08675

STV:	V470_05115

STRN:

SNAG_1096(yjjN)

SGW:	D7D53_03565

SAUP:

NCTC3168_00867

SVF:	NCTC3166_01881

STOY:

STYK_12350(tarJ)

SRUN:

LPB404_00345

LCS:

LCBD_2953

LCE:

LC2W_2927

LCW:	BN194_28680(tarJ)

LCB:	LCABL_29250(tdh)

LHN:	LHUE1_000866

LSL:	LSL_1953(tdh)

LSI:	HN6_01675(tdh)

PCE:

PECL_1839

PIO:	PI20285_08400

LEC:	LGMK_03550

WCE:

WS08_0696

WTR:	KHQ32_03740

WCT:

WS74_0698

WCI:	WS105_0758

WCB:	AO080_09190

WVR:	IE337_02015

WEI:	EQG49_03570

EGV:	EGCR1_00545

EAV:	EH197_09215

ERAF:

J9537_02390

TEY:	GLW17_02100

ADC:	FOC79_09370

GAD:	K8O88_07425

GEG:	LK443_06710

CBN:

CbC4_0710

CBT:

CLH_2995

CLS:	CXIVA_02110

CBV:

U729_1135

RUJ:	E5Z56_01295

EVN:	NQ558_02540

ALKA:

J0B03_04325

EUU:	ADJ67_05805

CHYL:

CE91St63_12470(tarJ)

EHL:

EHLA_2452

ACHT:

bsdcttw_42560

MFOR:

NQ534_03570

AHB:	bsdtb5_10800

LBX:

lbkm_2932

IPS:	CfP315_0302

PTRH:

RsTaC01_0810

PMIC:

NW74_04235

KPAR:

JL105_07985

EBM:	SG0102_21260

SHI:	Shel_14630

AHAT:

ADCFC_17180

DDT:	AAY81_02970

RTS:	CE91St31_00270

EBZ:	J7S26_07465

SGR:

SGR_4956

SGB:

WQO_10720

SFI:

SFUL_2153

SANL:

KZO11_10800

SCYE:

R2B67_25335

SSX:	SACTE_2009

SFA:

Sfla_4295

SDV:	BN159_5701

STRP:

F750_2413

SCI:	B446_13640

SXI:	SXIM_15330

STRC:

AA958_25170

SPRI:

SPRI_4927

SCZ:	ABE83_25180

SCX:	AS200_29490

SRW:	TUE45_03196(ispD1)

SRN:	A4G23_01658(ispD2)

STRT:

A8713_10140

SCLF:

BB341_19490

SGS:	AVL59_40270

STSI:

A4E84_13575

SCAD:

DN051_25530

SPHW:

NFX46_33840

SLS:	SLINC_2989

SNW:	BBN63_23745

SVU:	B1H20_09990

SLAU:

SLA_5894

SNZ:	DC008_11175

SGE:	DWG14_05586(bcs1)

SLK:	SLUN_13130

SDX:	C4B68_26825

SGD:	ELQ87_26380

SQZ:	FQU76_09345

SCYA:

EJ357_15535

STIR:

DDW44_08240

SGZ:	C0216_08925

SVN:	CP980_07690

SNK:	CP967_23320

SHAW:

CEB94_13980

SFIC:

EIZ62_22315

SGAL:

CP966_11970

SSPO:

DDQ41_06560

SPAD:

DVK44_09025

SFY:	GFH48_26815

SAQU:

EJC51_17065

SCAV:

CVT27_09510

SSUB:

CP968_08275

SFUG:

CNQ36_11780

STSU:

B7R87_09240

SCHA:

CP983_28710

SCOE:

CP976_15105

SBRO:

GQF42_16330

STUI:

GCM10017668_22430

SATA:

C5746_13975

SCHF:

IPT68_12435

SHAR:

HUT13_08350

SCYG:

S1361_14180(ispD1)

SFEU:

IM697_08240

SLIA:

HA039_23505

SVD:	CP969_14060

SCAL:

I6J39_10210

SFB:	CP974_09315

SPRA:

CP972_12305

SPEU:

CGZ69_11785

SGJ:	IAG43_10235

STRY:

EQG64_09805

SDD:	D9753_23735

SMAO:

CAG99_19295

SGOB:

test1122_22495

SSPN:

LXH13_14265

SCIR:

STRCI_002877

SJN:	RI060_28115

SOV:	QZH56_01215

SFIY:

F0344_25070

SKG:	KJK29_25455

SCOA:

QU709_28430

SCHG:

NRO40_09315

SINN:

ABB07_25205

KAB:	B7C62_09600

MOO:	BWL13_02200(bcs1)

MPRT:

ET475_11965

MTEC:

OAU46_11120

MELY:

L2X98_21190

MEST:

PTQ19_14625

AARC:

G127AT_03335

AMAU:

DSM26151_09170(bcs1)

ASOI:

MTP13_17175 MTP13_17185

AIL:	FLP10_03170

SALA:

ESZ53_05795

LALL:

MUN78_02250

NAEI:

GCM126_18250

ASUF:

MNQ99_09020

PAEY:

KUF55_10390

JDE:

Jden_1842

PHW:	G7075_10580

BLY:	A2T55_13845

BSPO:

L1F31_14280

MPH:	MLP_25850(ispD)

MIK:	FOE78_14050

MICG:

GJV80_06215

NFC:	KG111_01750

PSIM:

KR76_03415

AEZ:	C3E78_05735

AEB:	C6I20_04370

AEF:	GEV26_05500

ASEZ:

H9L21_04570

ADB:	NP095_04525

AWN:	NQV15_05630

MUZ:	H4N58_06600

SGRG:

L0C25_07910

THAO:

NI17_015585

TALX:

FOF52_12610 FOF52_12975

NAL:

B005_2753

NEX:	NE857_05460 NE857_28875

NEC:	KGD82_04090 KGD82_23655

NCG:	KGD84_27880 KGD84_27890

SNAH:

OUQ99_27405

SAIU:

J4H86_12520

AMAZ:

LUW76_21645

ACIR:

OG979_14555

ACTQ:

OG417_06925

SRO:

Sros_1351

NCX:	Nocox_05830(ispD2)

NGN:	LCN96_06510

NFS:	OIE67_40495

TBI:

Tbis_0719

MHAI:

OHB01_17350

KBU:	Q4V64_16675

STP:	Strop_1684

SAQ:

Sare_1679

MAU:	Micau_2081

MIL:

ML5_2188

MICB:

MicB006_5138

MTUA:

CSH63_14395

MICH:

FJK98_09765

MTEM:

GCE86_03895

MCAB:

HXZ27_10760

MSAG:

GCM10017556_43470

VMA:	VAB18032_13835

MCRA:

ID554_03250

VER:	HUT12_09925

MENO:

Jiend_08940

MCHL:

PVK74_01280

MFEU:

H1D33_16505

MPRN:

Q3V37_28040

MHAW:

RMN56_01660

PLAB:

C6361_28940

PLAT:

C6W10_06500

CATI:

CS0771_15200

SNG:	SNE_A02450(ispD)

RHAW:

RHABOEDO_000295

RPOR:

RHAB15C_0001222

OTE:

Oter_0455

FPD:	CTM68_07420

FMO:	C4N19_12405

BTH:

BT_1651

BTHO:

Btheta7330_01408(ispD2_2)

BUN:	Bun01g_05870

BHUM:

JXR92_013855

BFC:	BacF7301_03505

BSAL:

K6V25_15340

BDO:	EL88_23930

BDH:	GV66_07440

PCOP:

I6J50_15570

MICA:

P0L94_08875

PDI:

BDI_1841

MBAS:

ALGA_0189

FJO:

Fjoh_2239

FFA:	FFWV33_09175

FIA:	NA23_00555(ispD)

MRU:

mru_1057

MSI:

Msm_0376

MEB:

Abm4_1002

MMIL:

sm9_0634

MEYE:

TL18_03055

METV:

K4897_02400

MCUB:

MCBB_1533(tarJ)

TSI:

TSIB_2019

TPRF:

A3L09_01820

ABI:

Aboo_0706

» show all

Reference

1 [PMID:11305920]

Authors

Zolli M, Kobric DJ, Brown ED

Title

Reduction precedes cytidylyl transfer without substrate channeling in distinct active sites of the bifunctional CDP-ribitol synthase from Haemophilus influenzae.

Journal

Biochemistry 40:5041-8 (2001)
DOI:10.1021/bi002745n

Sequence

[hiu:HIB_11840]

Reference

2 [PMID:15362865]

Authors

Pereira MP, Brown ED

Title

Bifunctional catalysis by CDP-ribitol synthase: convergent recruitment of reductase and cytidylyltransferase activities in Haemophilus influenzae and Staphylococcus aureus.

Journal

Biochemistry 43:11802-12 (2004)
DOI:10.1021/bi048866v

Reference

3 [PMID:18556787]

Authors

Pereira MP, D'Elia MA, Troczynska J, Brown ED

Title

Duplication of teichoic acid biosynthetic genes in Staphylococcus aureus leads to functionally redundant poly(ribitol phosphate) polymerases.

Journal

J Bacteriol 190:5642-9 (2008)
DOI:10.1128/JB.00526-08

Reference

4 [PMID:19074383]