KEGG ENZYME: 1.1.1.413

ENZYME: 1.1.1.413

Entry

EC 1.1.1.413                Enzyme

Name

A-factor type gamma-butyrolactone 1'-reductase (1S-forming);
barS1 (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one:NADP+ 1'-oxidoreductase

Reaction(IUBMB)

a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP+ = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+ [RN:R11776]

Reaction(KEGG)

R11776

Substrate

(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one [CPD:C21666];
NADP+ [CPD:C00006]

Product

(3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one [CPD:C21668];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme, which is found in bacteria that produce virginiae-butanolide (VB) type gamma-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration.

History

EC 1.1.1.413 created 2017

Orthology

K22322

A-factor type gamma-butyrolactone 1'-reductase (1S-forming)

Genes

VOG:	LCH97_14275

ERAF:

J9537_10520

SANL:

KZO11_19675

SCYE:

R2B67_04415

SCB:	SCAB_12071

SSX:	SACTE_3174

SHY:	SHJG_4001 SHJG_8653

SHO:	SHJGH_3766 SHJGH_8413

SFA:	Sfla_3301 Sfla_6321

SDV:	BN159_4441

STRP:

F750_0226 F750_3442

SGU:	SGLAU_25510

STRE:

GZL_00105 GZL_09308

SCW:	TU94_11470

SLD:

T261_2142

STRM:

M444_36570

SCZ:	ABE83_19735

SCX:	AS200_24420

SRW:	TUE45_pSRc_0612(linC)

SLE:	sle_45930(sle_45930)

SRN:	A4G23_05427(linC_2)

SCLF:

BB341_16840

SALU:

DC74_7609

SALL:

SAZ_39260

SVU:	B1H20_15520

SGV:	B1H19_37525

SLAU:

SLA_3027

SALJ:

SMD11_6028

SRJ:

SRO_3380

SCYA:

EJ357_35235

SNQ:	CP978_34570

STIR:

DDW44_31510

SNK:	CP967_09555 CP967_17820 CP967_30570

SRK:	FGW37_31680

SFIC:

EIZ62_19140

SSPO:

DDQ41_04305 DDQ41_08115 DDQ41_31050

SGF:	HEP81_03592

SCAV:

CVT27_14850

SSUB:

CP968_00755 CP968_02875 CP968_15820

SCIN:

CP977_28700

SSPB:

CP982_00425 CP982_41465

SHUN:

DWB77_04715(linC)

SLIA:

HA039_29940

SCAL:

I6J39_15535

SFB:	CP974_28890

SANU:

K7396_07605

SDD:	D9753_04940 D9753_06790 D9753_09120

SMAO:

CAG99_21650

SLF:	JEQ17_45420

SAKB:

K1J60_19010

SNIG:

HEK616_52230

SCIR:

STRCI_004203

SLON:

LGI35_23835

SENG:

OJ254_00165

SGK:	PET44_34010

SYUN:

MOV08_00425 MOV08_43540

SFIY:

F0344_18555 F0344_34660 F0344_34855

STRH:

GXP74_01245 GXP74_06795

SUBA:

LQ955_03160

MSEA:

METESE_09550

» show all

Reference

1 [PMID:12193632]

Authors

Shikura N, Yamamura J, Nihira T

Title

barS1, a gene for biosynthesis of a gamma-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species.

Journal

J Bacteriol 184:5151-7 (2002)
DOI:10.1128/JB.184.18.5151-5157.2002

Sequence

[ag:BAA96298]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.413

IUBMB Enzyme Nomenclature:

1.1.1.413

ExPASy - ENZYME nomenclature database:

1.1.1.413

BRENDA, the Enzyme Database:

1.1.1.413

All links

Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (80)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (79)   
Protein sequence (24)   
   UniProt (23)   
   SWISS-PROT (1)   
DNA sequence (16)   
   GenBank (9)   
   EMBL (7)   
Protein domain (3)   
   InterPro (3)   
All databases (130)   

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