| Entry |
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| Name |
L-galactonate 5-dehydrogenase;
lgoD (gene name);
lgaC (gene name)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
L-galactonate:NAD+ 5-oxidoreductase
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| Reaction(IUBMB) |
L-galactonate + NAD+ = D-tagaturonate + NADH + H+ [RN: R12146]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme, reported from the human gut bacteria Escherichia coli and Bacteroides vulgatus, participates in an L-galactonate degradation pathway.
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| History |
EC 1.1.1.414 created 2018
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| Pathway |
| ec00053 | Ascorbate and aldarate metabolism |
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| Orthology |
| K23005 | L-galactonate 5-dehydrogenase |
| K23007 | L-galactonate 5-dehydrogenase |
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| Genes |
| ECOO: | ECRM13514_5617(yjjN) |
| ECOH: | ECRM13516_5331(yjjN) |
| EDJ: | ECDH1ME8569_4215(yjjN) |
| ECOI: | ECOPMV1_04815(tdh_5) |
| RTG: | NCTC13098_06016(tdh_3) |
| KIE: | NCTC12125_03110(tdh_1) |
| SFJ: | SAMEA4384070_1461(tdh_1) |
| SOF: | NCTC11214_05521(tdh_2) |
| PHEI: | NCTC12003_02862(tdh_1) |
| LRI: | NCTC12151_02880(tdh) |
| PAET: | NCTC13378_01838(idnD_3) |
| ACAC: | EYQ97_00600 EYQ97_13960 |
| BTHO: | Btheta7330_04668(yjmD_2) |
| BOA: | Bovatus_03714(yjmD_1) |
| BCEL: | BcellWH2_04739(yjmD_2) |
| STHA: | NCTC11429_02082(gutB_1) |
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| Reference |
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| Authors |
Cooper RA |
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| Title |
The pathway for L-galactonate catabolism in Escherichia coli K-12. |
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| Journal |
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| Reference |
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| Authors |
Kuivanen J, Richard P |
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| Title |
The yjjN of E. coli codes for an L-galactonate dehydrogenase and can be used for quantification of L-galactonate and L-gulonate. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hobbs ME, Williams HJ, Hillerich B, Almo SC, Raushel FM |
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| Title |
l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.414 |
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