Entry
Name
noscapine synthase;
NOS (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
narcotine hemiacetal:NAD+ 1-oxidoreductase
Reaction(IUBMB)
narcotine hemiacetal + NAD+ = noscapine + NADH + H+ [RN:
R10020 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from the plant Papaver somniferum (opium poppy), catalyses the last step in the biosynthesis of the isoquinoline alkaloid noscapine.
History
EC 1.1.1.415 created 2018
Pathway
ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
Genes
Taxonomy
Reference
Authors
Chen X, Facchini PJ.
Title
Short-chain dehydrogenase/reductase catalyzing the final step of noscapine biosynthesis is localized to laticifers in opium poppy.
Journal
Reference
Authors
Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke CD
Title
Complete biosynthesis of noscapine and halogenated alkaloids in yeast.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.415