KEGG ENZYME: 1.1.1.420

ENZYME: 1.1.1.420

Entry

EC 1.1.1.420                Enzyme

Name

D-apiose dehydrogenase;
apsD (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-apiofuranose:NAD+ 1-oxidoreductase

Reaction(IUBMB)

D-apiofuranose + NAD+ = D-apionolactone + NADH + H+ [RN:R12502]

Reaction(KEGG)

R12502

Substrate

D-apiofuranose [CPD:C21040];
NAD+ [CPD:C00003]

Product

D-apionolactone [CPD:C22218];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme, characterized from several bacterial species, is involved in a catabolic pathway for D-apiose.

History

EC 1.1.1.420 created 2019

Orthology

K23244

D-apiose dehydrogenase

Genes

YEL:	LC20_03977

YAK:	ACZ76_03285

YMA:	DA391_06270

YHI:	D5F51_15710

YKI:	HRD70_10740

COLW:

A3Q33_17725

CATE:

C2869_05170

GAI:	IMCC3135_02045(yhhX_1) IMCC3135_20395(yhhX_2) IMCC3135_21765(yhhX_3)

HAA:	A5892_08245

KMA:	B9H00_09335

BCAI:

K788_0005386

PSPW:

BJG93_30030

PTER:

C2L65_18735

PGP:	CUJ91_23805

PTS:	CUJ90_28675

PACP:

FAZ97_28280

PEW:	KZJ38_24870

PSAA:

QEN71_38390

AKA:	TKWG_00535

AMIM:

MIM_c01400

RHY:	RD110_19505

POL:

Bpro_3819

VAP:	Vapar_6269

VAA:	AX767_13030

HYL:	LPB072_16415 LPB072_19470

HYC:	E5678_14695

BEBA:

BWI17_02130

MLO:

mll7010

MLN:	A9174_13150

MCI:	Mesci_5311

MCIC:

A4R28_00555

MOP:	Mesop_5772

MAM:	Mesau_05267

MAMO:

A6B35_09525 A6B35_15265

MESW:

A9K65_029035

MESM:

EJ066_15520

MHUA:

MCHK_0234

MJR:	EB229_13285

MERD:

EB233_28460

MOH:	IHQ72_30645

MMEI:

LRP31_29975

MESO:

BSQ44_08090

PHT:	BLM14_21715

NIY:	FQ775_04630

NKI:	KW403_09355

ORM:	HTY61_08760 HTY61_11910

SME:

SM_b20353

SMK:	Sinme_3825

SMQ:	SinmeB_4321

SMX:	SM11_pD1260

SMI:	BN406_06319

SMEG:

C770_GR4pD1249

SMEL:

SM2011_b20353

SMER:

DU99_31530

SMD:

Smed_3766

RHI:	NGR_b22030

SFH:	SFHH103_05028

SFD:	USDA257_c23090

SIX:	BSY16_3623

SAME:

SAMCFNEI73_pC0431

SINO:

SS05631_b62710

ENU:	PYH37_000275

SKM:	PZL22_001117

EAD:	OV14_b0209

ECAA:

J3R84_34890

RET:	RHE_PF00033

REC:	RHECIAT_PC0000973

REL:	REMIM1_PF00037

RLE:	RL4420 pRL120389

RLT:	Rleg2_4658

RLG:	Rleg_3954 Rleg_4755

RLB:	RLEG3_07460 RLEG3_30850

RTR:	RTCIAT899_PC04810

RHL:	LPU83_pLPU83c0530

RGA:	RGR602_PC01948

RHN:	AMJ98_PE00036

RPHA:

AMC79_PD00980

RHX:	AMK02_PD00039

REZ:	AMJ99_PD00036

RJG:	CCGE525_32375

RHR:	CKA34_20650

RGR:	FZ934_27690

RAD:	CO657_28340

RII:	FFM53_014910 FFM53_024655

RBAN:

J2J98_22070

RRG:	J3P73_22875 J3P73_25320

RLS:	HB780_06745

RAW:	NE851_31400 NE851_33180

RSUL:

N2599_21450

RLW:	RlegWSM1455_19965 RlegWSM1455_25725

RRHO:

PR018_17250

RTU:	PR017_17135

ARA:

Arad_9238

RBW:	RLCC275e_20295 RLCC275e_25195

RIF:	U5G49_004074

RFV:	RFYW14_03811

SHZ:

shn_27380

SZO:	K8M09_21790

SOJ:	K6301_18790

SSUM:

Q9314_21115

KAI:	K32_08100 K32_40750

OIN:	IAR37_15410

OAN:

Oant_3060

OAH:

DR92_3443

OPS:	A8A54_12325

BPSN:

NIK97_14695

OCH:	CES85_5830

OCR:	HGK82_18425

OCL:	GTN27_19440

BOP:	AXW83_04865 AXW83_12440

BVV:	BHK69_03780

XDI:	EZH22_15220

STAR:

G3545_23065

LNE:	FZC33_05825

MET:

M446_1313

MMES:

MMSR116_11450

MTAD:

M6G65_24040

MOC:	BB934_35085 BB934_40840

MLD:	U0023_31715

CHEL:

AL346_05100

DEI:	C4375_04970

DNP:	N8A98_03290

DAG:	PSQ19_05595 PSQ19_10800 PSQ19_12140 PSQ19_12405

DRP:	PSQ90_09250

MMED:

Mame_04748(afr_4)

AUA:	M673_08895

AALA:

IGS74_19120

AALM:

LUX29_21310

AUZ:	Sa4125_32750

RBM:

TEF_16860

LAP:	ACP90_20155

LABR:

CHH27_00105

LABP:

FJ695_09720

LABT:

FIU93_26710(ydgJ) FIU93_28805(afr4)

LAGG:

B0E33_03880 B0E33_28845

RPOP:

K1718_20730

LIZ:	LGH83_09595

ACUT:

MRB58_05620 MRB58_21515

RUA:	D1823_13410

RUT:	FIU92_00100(afr1)

JAN:

Jann_3062

RDE:

RD1_3788

RLI:	RLO149_c006530

RPON:

G3256_03960

DSH:

Dshi_3394

OAR:	OA238_c24210

CMAR:

IMCC12053_385

MALG:

MALG_04066

YPAC:

CEW88_19410

TPRO:

Ga0080559_TMP299

SULZ:

C1J03_17545

SULI:

C1J05_01780

SMED:

JNX03_08285

SUAL:

KDD17_14090

SDUB:

R1T39_03375

TOM:	BWR18_11220

AHT:	ANTHELSMS3_02504(ligC) ANTHELSMS3_04965(iolX)

THAA:

CFI11_01770

OCD:	FHY55_04930 FHY55_15985

MALU:

KU6B_32170

HAT:	RC74_03020 RC74_11925 RC74_11940

PALX:

GQA70_00805 GQA70_20180

LSAL:

KBK07_12645

FYT:	QF092_01885

PARR:

EOJ32_13825

PLIA:

E4191_17645

PMAU:

CP157_00839(iolG_2)

PSAP:

JHX88_15320

DAA:	AKL17_3256

TEC:	AKL02_017820

GEH:	HYN69_13940

LIT:	FPZ52_12595

POZ:	I0K15_15440

PALW:

PSAL_036690(apsD_2)

PPAF:

I8N54_14200

CACT:

HZ995_04510

HDH:	G5B40_16325

FAP:	GR316_12720

AALK:

LGT41_0010945

AMAQ:

GO499_13005 GO499_14460

PBAE:

P8S53_15430 P8S53_19850

FAQ:	G5B39_17465

SCAB:

LZK98_19770

GOY:	GLS_c05880

ACR:

Acry_1061

AMV:	ACMV_08300

LCK:	HN018_21640

SHUM:

STHU_22600

SVC:	STVA_26220

SKT:	IGS68_04965

SMUC:

JL100_022755

SROE:

JL101_021440

FER:	FNB15_20160

HADH:

FRZ61_46810

THAR:

T8K17_15720 T8K17_18995

SNEA:

NBZ79_06410

BOU:	I5818_05095

PJD:	Pjdr2_3665

PPY:

PPE_03804

PAEQ:

R50912_07855

PRI:

PRIO_3529

PSWU:

SY83_22150

PPSC:

EHS13_08910

PALB:

EJC50_26040

PRZ:	GZH47_24970 GZH47_30105

PLYC:

GXP70_27330

PTRI:

KDC22_07460

PALO:

E6C60_0877 E6C60_1021

PPAB:

KET34_26065

PLAN:

A1s21148_06255

TTR:

Tter_1997

TRO:

trd_0133

CCOT:

CCAX7_25370

FPES:

NXS98_03455

RBA:

RB3770

MFF:	MFFC18_42680(idhA)

AHEL:

Q31a_38410(kynB)

BREM:

PSR63_25130

RLC:	K227x_46470(iolG_15)

SMAM:

Mal15_40850(ycjS_2)

SNEP:

Enr13x_29130(ligC_3)

PND:	Pla175_51100(kynB)

MRI:	Mal4_38880(ycjS_5)

CCOS:

Pan44_39340(iolG_12) Pan44_55480(kynB_2)

CCOP:

Mal65_01270(iolG_1)

SACI:

Sinac_4983

AGV:	OJF2_37170(ycjS_3)

ABAS:

ACPOL_4621

LUB:	TBR22_A12690

PMUC:

ING2E5A_0782

HHY:	Halhy_1306

MSAB:

SNE25_30235

SMON:

AWR27_07845

SOQ:	LQ777_09285

SENF:

GJR95_23830

RHOZ:

GXP67_17710

DFQ:	NFI81_04970

DPF:	ON006_08840

RSI:	Runsl_3639

CLIT:

OQ292_23185

FBT:	D770_14515

RCG:	N7E81_17120

PRHO:

PZB74_18045

TPEL:

P0M28_11635 P0M28_19590

MARE:

EJ994_10370

ZGA:	ZOBELLIA_3794

ZLA:	Q5W13_08100

FEK:	C1H87_18525

AQD:	D1816_12935

AQE:	NBT05_12555

ASAG:

FGM00_05285

ALUT:

O5O44_05050

» show all

Reference

1 [PMID:29867142]

Authors

Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA

Title

Functional assignment of multiple catabolic pathways for D-apiose.

Journal

Nat Chem Biol 14:696-705 (2018)
DOI:10.1038/s41589-018-0067-7

Sequence

[ara:Arad_9238]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.420

IUBMB Enzyme Nomenclature:

1.1.1.420

ExPASy - ENZYME nomenclature database:

1.1.1.420

BRENDA, the Enzyme Database:

1.1.1.420

All links

Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (1565)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (286)   
   KEGG MGENES (1278)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (4)   
   InterPro (4)   
All databases (1582)   

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