KEGG   ENZYME: 1.1.1.421
Entry
EC 1.1.1.421                Enzyme                                 
Name
D-apionate oxidoisomerase;
apnO (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-apionate:NAD+ oxidoreductase (isomerizing)
Reaction(IUBMB)
D-apionate + NAD+ = 3-oxoisoapionate + NADH + H+ [RN:R12503]
Reaction(KEGG)
R12503
Substrate
D-apionate [CPD:C22219];
NAD+ [CPD:C00003]
Product
3-oxoisoapionate [CPD:C22220];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. The reaction involves migration of a hydroxymethyl group from position 3 to position 2 and oxidation of the 3-hydroxyl group. Stereospecificity of the product, 3-oxoisoapionate, has not been determined.
History
EC 1.1.1.421 created 2019
Orthology
K23245  D-apionate oxidoisomerase
Genes
EFE: EFER_0433
SYM: K6K13_04240
AHN: NCTC12129_01617
ASUB: NLZ15_15030
IZH: FEM41_02315
RBAD: H2866_02220
RCB: O1V66_01105
ECA: ECA0869
PATR: EV46_03995
PATO: GZ59_08050
PCC: PCC21_007740
PCV: BCS7_03830
PAQU: DMB82_0016425
PVZ: OA04_08720
PQU: IG609_016190
PACB: M9782_06395
EBI: EbC_33080
EPE: CI789_01900
ERP: LJN55_16945
ETO: RIN69_16360
PAO: Pat9b_4284
KLN: LH22_13015
PANS: FCN45_09510
PPHO: CTZ24_26775
LRI: NCTC12151_01557
HHU: AR456_16015
HSV: HNO53_09520
HNP: SR894_15365
HAA: A5892_08225
KMA: B9H00_09310
MMW: Mmwyl1_3119
MME: Marme_1594
MPRI: MP3633_1136
MARD: IBG28_06430
MARS: A8C75_12425
LLP: GH975_02705
CNC: CNE_BB1p11570
BYI: BYI23_D003660
BUE: BRPE67_DCDS05380
BCAI: K788_0005389
PSPW: BJG93_30095
PHS: C2L64_29630
PTER: C2L65_18750
PGP: CUJ91_23790
PTS: CUJ90_28690
PACP: FAZ97_28265
PEW: KZJ38_24880
PSAA: QEN71_38375
BUO: BRPE64_DCDS09230
CABK: NK8_55260
TVL: FAZ95_14760
ODI: ODI_R0403
PACR: FXN63_20020
POL: Bpro_0087
AMON: H9L24_19530
VPD: VAPA_2c01350
HYL: LPB072_19445
HHT: F506_07870
HFR: G5S34_07105
MLO: mll7016
MLN: A9174_13175
MCI: Mesci_5306
MCIC: A4R28_00580
MOP: Mesop_5762 Mesop_5767
MAM: Mesau_05256 Mesau_05262
MAMO: A6B35_09550
MESW: A9K65_029010
MESM: EJ066_15555
MHUA: MCHK_0239
MJR: EB229_13310
MERD: EB233_28435
MOH: IHQ72_30610
MMEI: LRP31_29950
PHT: BLM14_21740
ORM: HTY61_08785
KMN: HW532_08970
SME: SM_b20348
SMK: Sinme_3830
SMQ: SinmeB_4326
SMX: SM11_pD1266
SMI: BN406_06324
SMEG: C770_GR4pD1254
SMEL: SM2011_b20348
SMER: DU99_31555
SMD: Smed_3771
RHI: NGR_b22080 NGR_c06730
SFH: SFHH103_05023
SFD: USDA257_c23040
SIX: BSY16_3618
SAME: SAMCFNEI73_pC0426
SINO: SS05631_b62760
ENU: PYH37_000270
SKM: PZL22_001112
EAD: OV14_b0214
ECAA: J3R84_34915
RET: RHE_PF00038
REC: RHECIAT_PC0000968
REL: REMIM1_PF00042
RLE: pRL120394
RLT: Rleg2_4653
RLG: Rleg_4760
RLB: RLEG3_07485
RTR: RTCIAT899_PC04835
RHL: LPU83_pLPU83c0535
RGA: RGR602_PC01943
RHN: AMJ98_PE00041
RPHA: AMC79_PD00975
RHX: AMK02_PD00044
REZ: AMJ99_PD00041
RJG: CCGE525_32350
RHR: CKA34_20625
RGR: FZ934_27715
RAD: CO657_28365
RII: FFM53_024630
RBAN: J2J98_22045
RRG: J3P73_25295
RLS: HB780_06770
RAW: NE851_33205
RSUL: N2599_21475
RLW: RlegWSM1455_25750
RRHO: PR018_17275
RTU: PR017_17160
ARA: Arad_9232
RBW: RLCC275e_25220
RFV: RFYW14_03816
SHZ: shn_27355
SZO: K8M09_21765
SOJ: K6301_18815
SSUM: Q9314_21090
ABAW: D5400_10070
OIN: IAR37_15435
OAN: Oant_3065
OAH: DR92_3438
OPS: A8A54_12350
BPSN: NIK97_14670
OCH: CES85_5835
OCR: HGK82_18450
OCL: GTN27_19415
BOP: AXW83_16405
BOS: BSY19_3215
BVV: BHK69_00380
BOI: BLM15_08495
BVES: QO058_28260
XAU: Xaut_2925
STAR: G3545_23095
LNE: FZC33_05855
SNO: Snov_3663
APOL: K9D25_01040
MNO: Mnod_2421
MEE: DA075_21765
MTEA: DK419_14945
MIND: mvi_46790
MOC: BB934_35060
MLD: U0023_31740
DAG: PSQ19_10595
MMED: Mame_04744
AUA: M673_08900
AALA: IGS74_19115
AALM: LUX29_21305
AUZ: Sa4125_32670 Sa4125_32740
JIE: OH818_14765
LABT: FIU93_28780
LAGG: B0E33_28820
SIW: GH266_14660
LIZ: LGH83_09570
ACUT: MRB58_21490
JAN: Jann_3066
OAT: OAN307_c00670
CMAR: IMCC12053_1017
TPRO: Ga0080559_TMP295
SMED: JNX03_08295
SPSE: SULPSESMR1_01384
OCD: FHY55_18960
MALU: KU6B_32130
PALX: GQA70_00790
TRY: QF118_06060
MARU: FIU81_13305
FYT: QF092_17835
PARR: EOJ32_13845
PLIA: E4191_04060 E4191_17665
PMAU: CP157_00835
PSAP: JHX88_15300
PTP: RCA23_c02800
TEC: AKL02_017800
LVS: LOKVESSMR4R_01067
GEH: HYN69_13925
AMAQ: GO499_14455
FAQ: G5B39_17445
RBX: I3V23_05320
SCAB: LZK98_19745
GOY: GLS_c05840
ACR: Acry_1069
AMV: ACMV_08220
LCK: HN018_21585
SKT: IGS68_04930
SMUC: JL100_022810
SROE: JL101_021500
PSYB: KD050_04790
PSWU: SY83_22155
PPSC: EHS13_08895
PALB: EJC50_24830
PRZ: GZH47_24965
PLYC: GXP70_27325
AFX: JZ786_23515
PETR: QKW49_01005
AGAT: RWV98_13055 RWV98_17985
BYL: A4V09_12480
BPRO: PMF13cell1_02749
BLAR: LC508_10205
BHV: BLHYD_08770(apnO)
CBIL: EUBC25_09190
IFN: GM661_15975
SELT: BCS37_00455
SCO: SCO0576(SC5G5.08c)
SMAL: SMALA_4776
SSOI: I1A49_27990
SFA: Sfla_3625
SBH: SBI_04326
STRP: F750_3092
SLV: SLIV_35065
SXI: SXIM_40220
SCZ: ABE83_02045
SGM: GCM10017557_02940
STRD: NI25_01435
SAUO: BV401_27740
SGD: ELQ87_37485
SPAD: DVK44_35090
SFUG: CNQ36_25915
SHAR: HUT13_20070
MTS: MTES_2012
MIP: AXH82_06840
MPAL: BO218_08380
MHOS: CXR34_02895
MLV: CVS47_02893
MICS: C1N74_02580
MELY: L2X98_29320
MARK: QUC20_02350
MRG: SM116_03830
RFS: C1I64_09305
CUB: BJK06_01745
CQF: GBG65_13560
AMAU: DSM26151_02430(apnO)
AMAV: GCM10025877_18550
CPHY: B5808_01905
PSAI: C3B54_111591
MSPO: KXZ72_12085
HUM: DVJ78_00755
LYD: D7I47_03120
PLAP: EAO79_04825
HEA: HL652_16140
FRN: F1C15_12640
NAEI: GCM126_14510
ARR: ARUE_c18600
ARH: AHiyo8_31000
ARQ: BWQ92_12040
ARN: CGK93_09900
BRX: BH708_13640
BGG: CFK41_17140
BSAU: DWV08_14425
BKI: M4486_14710
BRHA: NLU66_02700
BHH: Bra3105_11720
GYU: FE374_03555
HALT: IM660_18430
RHAL: LQF10_18185
RSUA: LQF12_15500
PACD: EGX94_08900
PAUS: NCTC13651_02079
MIK: FOE78_11435
PROP: QQ658_04635
APRE: CNX65_13450
AMI: Amir_2651
ACTI: UA75_20490
ACAD: UA74_19990
ACTA: C1701_04365
PMAD: BAY61_13405
PLAN: A1s21148_07065
RMAR: GBA65_17545
BSOL: FSW04_03585
BALA: DSM104299_04070(apnO)
TRO: trd_0130
CCOT: CCAX7_25390
FPES: NXS98_03460
AGV: OJF2_37220
ABAS: ACPOL_4618
MICA: P0L94_11570
PMUC: ING2E5A_0783
HHY: Halhy_1310
MSAB: SNE25_30240
SMON: AWR27_07850
SOQ: LQ777_09270
SENF: GJR95_23865
RHOZ: GXP67_19790
DFQ: NFI81_07845
DPF: ON006_08820
RSI: Runsl_3636
FBT: D770_14530 D770_14630
TPEL: P0M28_14580
HALJ: G9465_24130
HALG: HUG10_07080
HSAL: JMJ58_22915
 » show all
Reference
1  [PMID:29867142]
  Authors
Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA
  Title
Functional assignment of multiple catabolic pathways for D-apiose.
  Journal
Nat Chem Biol 14:696-705 (2018)
DOI:10.1038/s41589-018-0067-7
  Sequence
[ara:Arad_9232]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.421
IUBMB Enzyme Nomenclature: 1.1.1.421
ExPASy - ENZYME nomenclature database: 1.1.1.421
BRENDA, the Enzyme Database: 1.1.1.421

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Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (588)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (305)   
   KEGG MGENES (282)   
Protein sequence (12)   
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DNA sequence (8)   
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