KEGG ENZYME: 1.1.1.424

ENZYME: 1.1.1.424

Entry

EC 1.1.1.424                Enzyme

Name

D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming);
xacA (gene name);
xdh (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,4-lactone-forming)

Reaction(IUBMB)

D-xylose + NADP+ = D-xylono-1,4-lactone + NADPH + H+ [RN:R12643]

Reaction(KEGG)

R12643

Substrate

D-xylose [CPD:C00181];
NADP+ [CPD:C00006]

Product

D-xylono-1,4-lactone [CPD:C02753];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme, which participates in the degradation of D-xylose, has been characterized from several halophilic archaeal species. cf. EC 1.1.1.179, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming).

History

EC 1.1.1.424 created 2020

Pathway

ec00040

Pentose and glucuronate interconversions

ec01100

Metabolic pathways

Orthology

K24442

D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)

Genes

HHB:	Hhub_4012 Hhub_4091

HNO:	LT974_07990

HALR:

EFA46_009975 EFA46_010985 EFA46_011180

HJE:	HacjB3_02295 HacjB3_03200 HacjB3_05780

HDO:	MUK72_10720

HALX:

M0R89_09680 M0R89_16690

HAXZ:

M0R88_09955 M0R88_16895

HAYC:

NGM10_05935

HAXY:

NGM07_02755 NGM07_15595 NGM07_22850 NGM07_22960

SALI:

L593_08020

HMA:	pNG7191(gfo2) rrnAC3034(gfo6)

HHI:	HAH_0291 HAH_5355(gfo4)

HHN:	HISP_01540 HISP_19955

HAB:	SG26_09370 SG26_18100

HTA:	BVU17_01425 BVU17_16040

HALJ:

G9465_01150 G9465_11050

HSIN:

KDQ40_12210 KDQ40_20300

HUT:

Huta_2274

HTI:

HTIA_1971

HALA:

Hrd1104_00795

HASV:

SVXHr_2301(xacA)

HABN:

HBNXHr_2292(xacA)

HMU:

Hmuk_2533

HALZ:

E5139_15810

HALL:

LC1Hm_1813(xdh)

HAZP:

GBQ70_15830

HALI:

BV210_12335

HDS:	HSR122_1642(mviM3)

HRR:	HZS55_09950 HZS55_16380 HZS55_21940

HPEL:

HZS54_15205 HZS54_19155 HZS54_25430

HLT:	I7X12_14445 I7X12_19035 I7X12_19515

SSAI:

N0B31_02385

HAAD:

MW046_12180 MW046_12920 MW046_14155 MW046_14340

HWA:

HQ_3202A

HWC:

Hqrw_3764

HVO:	HVO_A0330 HVO_B0028(xacA)

HGI:	ABY42_15585

HALE:

G3A49_05315 G3A49_07045

HLN:	SVXHx_3444(xacA) SVXHx_4189(xacA)

HALM:

FCF25_13805

HLA:	Hlac_1560 Hlac_2241

HALP:

DOS48_12410

HALB:

EKH57_12905

HEZZ:

EO776_13375

HALQ:

Hrr1229_008625

HSS:	J7656_02875

HSAI:

HPS36_08250

HAZZ:

KI388_12275

SRUB:

C2R22_01265 C2R22_14900

HALN:

B4589_002340 B4589_002525

HALG:

HUG10_06145 HUG10_08065 HUG10_16045

HALU:

HUG12_08080

HMP:	K6T50_05830 K6T50_17825

HRE:	K6T36_05565 K6T36_16885

HRM:	K6T25_10215 K6T25_13160

HACB:

Hbl1158_12160 Hbl1158_15055

HDF:	AArcSl_0519

HAH:	Halar_3506

HTU:	Htur_0531 Htur_4116 Htur_4497

HSAL:

JMJ58_06465 JMJ58_22330 JMJ58_23275

HAKZ:

J0X25_10045

HXA:	Halxa_0582 Halxa_1863 Halxa_3767 Halxa_3993

NAT:

NJ7G_0683

NPE:	Natpe_3458

NVR:	FEJ81_08200 FEJ81_16840

NPL:	FGF80_15705

NAY:	HYG81_01595 HYG81_01625

HALY:

HYG82_17880

HJT:	DVR14_07440

HLO:	J0X27_10455

SAWL:

NGM29_12785

HALV:

NGM15_11720

NOU:	Natoc_1104 Natoc_3157

HLR:	HALLA_04515 HALLA_06500

NAS:	GCU68_19960

HDA:	BB347_11275

» show all

Reference

1 [PMID:15342590]

Authors

Johnsen U, Schonheit P

Title

Novel xylose dehydrogenase in the halophilic archaeon Haloarcula marismortui.

Journal

J Bacteriol 186:6198-207 (2004)
DOI:10.1128/JB.186.18.6198-6207.2004

Sequence

[hma:rrnAC3034]

Reference

2 [PMID:19584053]

Authors

Johnsen U, Dambeck M, Zaiss H, Fuhrer T, Soppa J, Sauer U, Schonheit P

Title

D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii.

Journal

J Biol Chem 284:27290-303 (2009)
DOI:10.1074/jbc.M109.003814

Sequence

[hvo:HVO_B0028]

Reference

3 [PMID:28854683]

Authors

Sutter JM, Johnsen U, Schonheit P

Title

Characterization of a pentonolactonase involved in D-xylose and L-arabinose catabolism in the haloarchaeon Haloferax volcanii.

Journal

FEMS Microbiol Lett 364:3898818 (2017)
DOI:10.1093/femsle/fnx140

Sequence

[hvo:HVO_B0028]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.424

IUBMB Enzyme Nomenclature:

1.1.1.424

ExPASy - ENZYME nomenclature database:

1.1.1.424

BRENDA, the Enzyme Database:

1.1.1.424

DBGET integrated database retrieval system