| Entry |
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| Name |
(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase;
bbsCD (gene name)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA:NAD+ oxidoreductase
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| Reaction(IUBMB) |
(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD+ = (S)-2-benzoylsuccinyl-CoA + NADH + H+ [RN: R05575]
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| Reaction(KEGG) |
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| Substrate |
(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA [CPD: C09819];
NAD+ [CPD: C00003]
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| Product |
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| Comment |
The enzyme, purified from the bacterium Thauera aromatica, is involved in an anaerobic toluene degradation pathway. It is specific for NAD+.
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| History |
EC 1.1.1.429 created 2022
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K07547 | (2S)-[(R)-hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase BbsC subunit |
| K07548 | (2S)-[(R)-hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase BbsD subunit |
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| Genes |
| EBA: | c2A313(bbsD) c2A314(bbsC) |
| APET: | ToN1_01580(bbsD) ToN1_01590(bbsC) |
| AZI: | AzCIB_4523 AzCIB_4524 |
| AZD: | CDA09_07430 CDA09_07435 CDA09_21980 CDA09_21985 |
| TAK: | Tharo_3087 Tharo_3088 |
» show all
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| Reference |
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| Authors |
von Horsten S, Lippert ML, Geisselbrecht Y, Schuhle K, Schall I, Essen LO, Heider J. |
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| Title |
Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.429 |
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