KEGG   ENZYME: 1.1.1.433
Entry
EC 1.1.1.433                Enzyme                                 
Name
sulfoacetaldehyde reductase (NADH);
sarD (gene name);
tauF (gene name);
sqwF (gene name);
BkTauF
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
isethionate:NAD+ oxidoreductase
Reaction(IUBMB)
isethionate + NAD+ = 2-sulfoacetaldehyde + NADH + H+ [RN:R13009]
Reaction(KEGG)
R13009
Substrate
isethionate [CPD:C05123];
NAD+ [CPD:C00003]
Product
2-sulfoacetaldehyde [CPD:C00593];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzymes from the bacteria Bilophila wadsworthia and Clostridium sp. MSTE9 catalyse the reaction only in the reduction direction. In the bacterium Bifidobacterium kashiwanohense the optimal reaction pH for sulfoacetaldehyde reduction is 7.5, while that for isethionate oxidation is 10.0. cf. EC 1.1.1.313, sulfoacetaldehyde reductase (NADPH).
History
EC 1.1.1.433 created 2022
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K25985  sulfoacetaldehyde reductase (NADH)
Genes
APRLPY247_20480
OALNB647_05325
DFIAXF13_01465
DBADbac_1584
DPSDP0542 DP0546
DEOCAY53_09715
BSMBSM4216_2470
APAKAP3564_07955
PASABAOM_1155(yiaY)
BAGBcoa_0947
STEAC0679_03240
SHVAAT16_10375
JEAJEM45_10545
CPASClopa_0949
CBUTATN24_00660
RPAYP0092_15965
FPLAA4U99_15655
INTRX717_02205
BMASLK422_01770
BKAAH68_00250
BEUBE0216_06995
BSUEBS3272_06430
MAEOJRV97_03420
 » show all
Reference
1  [PMID:30718429]
  Authors
Peck SC, Denger K, Burrichter A, Irwin SM, Balskus EP, Schleheck D.
  Title
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia.
  Journal
Proc Natl Acad Sci U S A 116:3171-3176 (2019)
DOI:10.1073/pnas.1815661116
  Sequence
Reference
2  [PMID:30962433]
  Authors
Xing M, Wei Y, Zhou Y, Zhang J, Lin L, Hu Y, Hua G, N Nanjaraj Urs A, Liu D, Wang F, Guo C, Tong Y, Li M, Liu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria.
  Journal
Nat Commun 10:1609 (2019)
DOI:10.1038/s41467-019-09618-8
Reference
3  [PMID:31123167]
  Authors
Zhou Y, Wei Y, Nanjaraj Urs AN, Lin L, Xu T, Hu Y, Ang EL, Zhao H, Yuchi Z, Zhang Y.
  Title
Identification and characterization of a new sulfoacetaldehyde reductase from the human gut bacterium Bifidobacterium kashiwanohense.
  Journal
Biosci Rep 39:BSR20190715 (2019)
DOI:10.1042/BSR20190715
  Sequence
Reference
4
  Authors
Liu, J., Wei, Y., Ma, K., An, J., Liu, X., Liu, Y., Ang, E.L., Zhao, H. and Zhang, Y.
  Title
Mechanistically diverse pathways for sulfoquinovose degradation in bacteria.
  Journal
ACS Catal 11:14740-14750 (2021)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.433
IUBMB Enzyme Nomenclature: 1.1.1.433
ExPASy - ENZYME nomenclature database: 1.1.1.433
BRENDA, the Enzyme Database: 1.1.1.433

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