KEGG ENZYME: 1.1.1.435

ENZYME: 1.1.1.435

Entry

EC 1.1.1.435                Enzyme

Name

L-fucose dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

beta-L-fucopyranose:NADP+ 1-oxidoreductase

Reaction(IUBMB)

beta-L-fucopyranose + NADP+ = L-fucono-1,5-lactone + NADPH + H+ [RN:R13105]

Reaction(KEGG)

R13105

Substrate

beta-L-fucopyranose [CPD:C20836];
NADP+ [CPD:C00006]

Product

L-fucono-1,5-lactone [CPD:C18028];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme, characterized from the bacterium Burkholderia multivorans, participates in an L-fucose degradation pathway. The enzyme catalyses the oxidation of beta-L-fucopyranose to L-fucono-1,5-lactone, which is unstable and is rapidly converted to L-fucono-1,4-lactone. The alpha anomer is not recognized. The enzyme can also act on beta-L-galactopyranose and D-arabinose with lower activity. NADP+ is a better cosubstrate than NAD+.

History

EC 1.1.1.435 created 2022

Pathway

ec00051

Fructose and mannose metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K18333

L-fucose dehydrogenase

Genes

CCON:

AFK62_18615

EAE:

EAE_05260

EAR:

CCG32946

PGE:	LG71_02970

IZH:	FEM41_03690

SMAR:

SM39_4975

SMAC:

SMDB11_4718

SMW:	SMWW4_v1c05980

SPE:

Spro_0642

SRR:	SerAS9_0578

SRL:	SOD_c05100(fabG2)

SRY:	M621_02690

SPLY:

Q5A_002680(linC_1)

SRS:	SerAS12_0578

SRA:	SerAS13_0578

SMAF:

D781_0588

SLQ:	M495_02555

SERF:

L085_01110

SERS:

SERRSCBI_02830

SRZ:	AXX16_4521

SERM:

CLM71_02850

SQU:	E4343_13445

SFJ:	SAMEA4384070_0669(lvr_1)

SOF:	NCTC11214_00914(lvr)

SSUR:

ATE40_023670

SURI:

J0X03_20995

SRHZ:

FO014_06990

SENP:

KHA73_02725

SNEM:

NLX84_02870

SNEV:

OI978_03570

RAH:	Rahaq_4615

RACE:

JHW33_23670

RAQ:	Rahaq2_4620

RAA:

Q7S_23601

RVC:	J9880_22720

RBON:

QNM34_09895

RIU:	I2123_23060

EAME:

GXP68_21935

CARU:

P0E69_17430

NIG:	C1N62_15000

EBI:

EbC_34960

EGE:	EM595_p0338

KPIE:

N5580_19985

PJP:	LAG73_00450

POR:	APT59_18370

PLUL:

FOB45_19505

PDR:	H681_03975

PFZ:	AV641_17025

PLQ:	AA042_16680

PPSY:

AOC04_14295

PYM:	AK972_3693

PGG:	FX982_03440

PPSH:

G5J76_20740

PTAE:

NCTC10697_03282(ydaD)

ABER:

BSR55_03500

WOC:	BA177_04490

SALN:

SALB1_1054

VMS:	LVJ82_03550

AFF:	H3L97_08430

ACRS:

LVJ80_02370

CKH:	LVJ77_06265

RWE:	KOL96_14840

CUH:	BJN34_27325

BMA:

BMAA0644

BML:	BMA10229_0820

BMN:	BMA10247_A1782

BMAL:

DM55_4782

BMAE:

DM78_3207

BMAQ:

DM76_3736

BMAI:

DM57_12325

BMAF:

DM51_4360

BMAZ:

BM44_4772

BMAB:

BM45_4960

BPS:

BPSS0794

BPM:	BURPS1710b_A2378

BPL:	BURPS1106A_A1085

BPD:	BURPS668_A1162

BPSE:

BDL_4076

BPSM:

BBQ_5348

BPSU:

BBN_4248

BPSD:

BBX_5914

BPZ:	BP1026B_II0872

BPQ:	BPC006_II1109

BPK:

BBK_3651

BPSH:

DR55_4547

BPSA:

BBU_5242

BPSO:

X996_4023

BUT:

X994_3775

BTE:	BTH_II1602

BTQ:

BTQ_4889

BTJ:

BTJ_3514

BTZ:

BTL_4362

BTD:

BTI_5612

BTV:

BTHA_3594

BTHE:

BTN_4014

BTHM:

BTRA_4079

BTHA:

DR62_4049

BTHL:

BG87_4345

BOK:

DM82_4915

BOC:

BG90_5680

BHG:	I6G56_24010

BUD:	AQ610_26700

BVI:	Bcep1808_3383

BVE:

AK36_3378

BUR:	Bcep18194_B0623

BCM:	Bcenmc03_5244

BCH:	Bcen2424_5040

BCJ:

BCAM2283

BCEN:

DM39_6870

BCEW:

DM40_4983

BCEO:

I35_6174

BAM:

Bamb_4448

BAC:	BamMC406_4968

BMJ:	BMULJ_04919(fabG)

BMU:

Bmul_3598

BMK:

DM80_4983

BMUL:

NP80_4942

BCT:

GEM_3407

BCED:

DM42_5708

BCEP:

APZ15_27700

BDL:

AK34_3516

BPYR:

ABD05_24170

BCON:

NL30_01145

BUB:

BW23_3447

BDF:	WI26_24100

BLAT:

WK25_27395

BTEI:

WS51_08435

BSEM:

WJ12_31305

BPSL:

WS57_14830

BMEC:

WJ16_29755

BSTG:

WT74_30135

BSTL:

BBJ41_25165

BANN:

JFN94_29260

BARI:

NLX30_25865

BAEN:

L3V59_25925

BGL:	bglu_1g17980

BGU:

KS03_2653

BGD:	bgla_1g19910 bgla_2g00990

BGO:	BM43_3333 BM43_6849

BUK:

MYA_3001

BUL:

BW21_5300

BGP:	BGL_1c19910

BPLA:

bpln_1g18230

BURK:

DM992_22840

AKA:	TKWG_18800

AMIM:

MIM_c09600

RFR:

Rfer_3136

RSB:	RS694_10700

RHG:	EXZ61_10370

DLA:	I6G47_12580

VAP:	Vapar_5322

VPE:	Varpa_1438

VPD:	VAPA_2c06620

VAM:	C4F17_11870

HSE:	Hsero_1047

HSZ:	ACP92_05240

HHT:	F506_01420

HRB:	Hrubri_0846

HEE:	hmeg3_21070

HHF:	E2K99_04890

HFR:	G5S34_05215

CFU:	CFU_2101(sdr3)

CARE:

LT85_1598

CPRA:

CPter91_1564

MESP:

C1M53_07795

AAK:	AA2016_0903

AMIH:

CO731_01018(linC)

AMIS:

Amn_53260

ANJ:

AMD1_0988

SINO:

SS05631_c11090

ESJ:	SJ05684_c19530

EAK:	EKH55_1890

BAPI:

BBC0122_013290

DEVO:

H4N61_01085

JAV:	OXU80_02345

PPHR:

APZ00_17325

ACUT:

MRB58_19645

PLCG:

RVY76_05230

FYT:	QF092_02195

PYE:	A6J80_02440

PCON:

B0A89_08935

PZH:	CX676_17890

PTP:	RCA23_c24610

GEH:	HYN69_09660

TAW:	EI545_01415

NSM:	JO391_16695

RHOC:

QTA57_10480

RBX:	I3V23_02015

SSAN:

NX02_10175

SAER:

NEF64_09675

ACR:

Acry_1855

AMV:	ACMV_20960

GDI:

GDI2664

GDJ:

Gdia_0877

LCK:	HN018_02395

ACIM:

GT370_09085

CJE:

Cj0485

CJB:	BN148_0485

CJI:

CJSA_0456

CJS:

CJS3_0477

CJP:	A911_02375

CJEJ:

N564_00472

CJEU:

N565_00521

CJEN:

N755_00520

CJEI:

N135_00537

CJER:

H730_03005

CJY:	QZ67_00496(fabG_2)

CJQ:	UC78_0473(xecE)

CJW:	PJ18_02415

CJR:

CJE0535

CJD:	JJD26997_1449

CJZ:	M635_06785

CFF:	CFF8240_1065

CFT:	CFF04554_1052

CFV:	CFVI03293_1020

CFX:	CFV97608_1119

CFZ:

CSG_9300

CAMP:

CFT03427_1045

CFP:	CR44_05315

CCC:	G157_06215

CCF:

YSQ_07415

CCY:

YSS_02240

CCOI:

YSU_06425

CCOF:

VC76_02555(ped)

CCOO:

ATE51_03232(ped)

CIS:

CINS_1511

CUX:	CUP3940_1290

CGEO:

CGEO_0774

MHW:	ACT01_03140

PCAT:

Pcatena_05880

ATB:	J4859_04870

LCAL:

ATTO_12990(fabG)

CII:	CIMIT_11865

CSTA:

CSTAT_07560

CAMG:

CAMM_07790

CPRP:

I6I69_03105

CPSP:

L9H27_08345

AUL:	DCC27_010570

AIG:	QDX25_10550

AWL:	P8A24_00420

ACAS:

P7079_00265

AUU:	CJ184_005290

BLN:	Blon_2308 Blon_2339

BLON:

BLIJ_2382 BLIJ_2416

BLL:	BLJ_0323 BLJ_1835

BLX:	GS08_01700 GS08_09525

BBV:	HMPREF9228_0577 HMPREF9228_1822

BBRU:

Bbr_1291 Bbr_1743

BBRE:

B12L_1237 B12L_1673

BBRV:

B689b_1320 B689b_1771

BBRJ:

B7017_1262 B7017_1937

BBRC:

B7019_1909

BBRN:

B2258_1266 B2258_1763

BBRS:

BS27_1314 BS27_1736

BBRD:

BBBR_1352 BBBR_1744

BKA:	AH68_10235

BKS:

BBKW_1836

BPSC:

BBPC_1773

BSCA:

BBSC_0457

GVG:	HMPREF0421_20694

GVH:	HMPREF9231_0871

GPT:	K9E43_05750

OBG:	Verru16b_01340(fabG_3)

SLOM:

PXH66_18115

PPHT:

GA004_03645

LCRE:

Pla8534_53430(fabG_10)

AAGG:

ETAA8_11660(fabG_3)

FMR:	Fuma_05288(ydaD_2)

TPOL:

Mal48_34420(ydaD)

LPRO:

PQO03_03205 PQO03_05795

ACA:

ACP_3287

ACM:	AciX9_3842

GMA:	AciX8_2947

TSA:	AciPR4_1795

TRS:	Terro_2915

TALB:

FTW19_09845

ORP:	MOP44_05820

CPI:

Cpin_1993

CBAE:

COR50_21125

CHIT:

FW415_09670

CHIH:

GWR21_25415

COY:	HF329_32155

CFIL:

MYF79_09920

CHF:	KTO58_16870

CHOR:

MKQ68_15630

CSAC:

SIO70_11360

NKO:	Niako_6701

FLA:	SY85_13655

FGG:	FSB75_09535

ARB:	A9P82_02005

ARK:	D6B99_13015

AGI:	FSB73_14295

ATEE:

K9M52_13775

ARAC:

E0W69_010530

FLN:

FLA_0504

PSEG:

D3H65_02500

PGIN:

FRZ67_19515

PGO:	FSB84_17590

FLS:	GLV81_12915

LACS:

H4075_11695

FLC:	KJS93_07865

FLV:	KJS94_02130

THEO:

IMW88_09235

HHY:	Halhy_4138

PHE:	Phep_2740 Phep_4015

PEP:	AQ505_01850

PCM:	AY601_0774

PSTY:

BFS30_06755

PGS:	CPT03_17080

PEJ:	FYC62_09475

PEK:	FFJ24_004975 FFJ24_008310

PROE:

H9L23_05575 H9L23_10350

PEX:	IZT61_02665

PMUO:

LOK61_06575

PRK:	H9N25_05015

PGJ:	QG516_13340

SHG:	Sph21_0618

SHT:	KO02_11055

SPHN:

BV902_22830

SMIZ:

4412673_01332(fabG_1)

SPSC:

E2P86_11865

SPHZ:

E3D81_06105

SPHE:

GFH32_05875

SPDR:

G6053_06125

SDJ:	NCTC13534_02085(srlD)

STHA:

NCTC11429_00386(fabG_1)

SSPI:

I6J01_18425

SMUI:

I6J00_11405

SSIY:

JVX97_08410

SFAE:

MUK51_05475

SBAM:

SCB77_04160

SCN:	Solca_1649

SLAS:

L2B55_09970

MUP:	A0256_16515

MUC:

MuYL_3109

MGOT:

MgSA37_02345(lvr)

MUH:	HYN43_020430

MGIN:

FRZ54_12050

MGK:	FSB76_16470

MRUB:

DEO27_020540

MGOS:

DIU38_021535

MMAB:

HQ865_21800

MJJ:	PQO05_09110

MSAB:

SNE25_31420

AGD:	FRZ59_09075 FRZ59_12425

OLI:	FKG96_26565

SBX:	CA265_04665 CA265_08605

ALM:	AO498_13045

ALGO:

GYM62_03100

SLI:

Slin_0310

SRD:	SD10_04865

SMON:

AWR27_16785

SPIR:

CWM47_12960

SPIK:

EXU85_25560

SPIB:

G8759_03360 G8759_11315

STAE:

HNV11_07595

SRHO:

HH216_02115

SOQ:	LQ777_07125 LQ777_27520

SFOL:

H3H32_21960

SENF:

GJR95_13760 GJR95_28290

RHOZ:

GXP67_13235

PSEZ:

HME7025_01464

AANH:

G9X63_10130

ALEN:

G9X62_10270

LBY:

Lbys_2061

EOL:	Emtol_1887

EMZ:	MB380_18515

ALS:	DJ013_18150

MAQA:

LAG90_13300

DFE:

Dfer_5643

DSN:	HWI92_10095

DYC:	NFI80_10845

DFQ:	NFI81_11055

DCN:	MUK70_13955

DPF:	ON006_02000

RSI:	Runsl_0250

RUN:	DR864_24130

RUP:	DTQ70_00010

FAE:

FAES_4384

FIB:	A6C57_13955

HYJ:	FHG12_02060

HQI:	H9L05_00095

HBN:	GUY19_16655

HMT:	MTP16_13510

HTB:	MTX78_20690 MTX78_23820

HSK:	H4317_06945

HAEI:

MUN82_11325

HVL:	MUN86_20630

PKO:	PKOR_02935

RTI:	DC20_02260 DC20_21540

ADD:	HUW48_15470

ASWU:

HUW51_23170

CLIT:

OQ292_05060

IRO:	RT717_20230

FBT:	D770_05970

CHK:	D4L85_15875 D4L85_18570

FUA:	LVD17_12210

REK:	N6H18_01415 N6H18_16680

RCG:	N7E81_01910

PRHO:

PZB74_01150

TPEL:

P0M28_00505

GFO:

GFO_1703

FJO:

Fjoh_4118

FJG:	BB050_01492(cpnA_1) BB050_03317(cpnA_3)

FGL:	EM308_01515 EM308_12725

FCM:	BIW12_13825

FCR:	HYN56_05695 HYN56_20460

FNK:	E1750_15430

FFL:	HYN86_05075 HYN86_16945

FEN:	J0383_20910

FPB:	NLJ00_20395

FBI:	L0669_05685

FPLU:

NLG42_17920 NLG42_18520

FHU:	M0M44_05760 M0M44_19535

FPEC:

Q1W71_14630

ZPR:

ZPR_4360

FBC:	FB2170_03375

MARM:

YQ22_01955 YQ22_02030

MART:

BTR34_02405

MARB:

CJ263_04600

CAO:	Celal_2510

CLY:	Celly_0417

CLH:	IX49_01785

CBAL:

M667_00140 M667_09845

CBAT:

M666_00140 M666_09835

COMN:

PBN93_02115

ZGA:	ZOBELLIA_3474 ZOBELLIA_4684

ZLA:	Q5W13_00830

POB:	LPB03_10285

PRN:	BW723_04175

PHAL:

H9I45_05985

PBAT:

JL193_04255

PCEA:

J3359_17655

AHZ:	APS56_05885

WFU:	AXE80_03615 AXE80_06975

SALT:

AO058_08755

AALG:

AREALGSMS7_01714

FEK:	C1H87_17900

MARF:

CJ739_935

AQB:	D1818_05210

AQD:	D1816_09345

AQE:	NBT05_07505

EMAR:

D1013_11500

SINH:

LS482_01715

FLG:	LV716_14050

SABU:

MBM09_08965

ZSP:	MQE36_10205

SAHN:

JRG66_07450

AEST:

RBH94_03335

HWS:	RNZ46_11875

EAO:

BD94_3584

EMN:	M876_14995

EEN:	BBD30_08760

ELB:	VO54_03061(fabG_3)

EMG:	BBD33_05555

EGO:	BBD34_07275

EGM:	AYC65_19755

ELZ:	FCS00_12935

ELT:	FGE20_09310

ELIZ:

JCR23_12830

CIH:	ATE47_10465

CIL:	EG358_10840

CLAC:

EG342_24645

CTUR:

LNP04_00540

CFLU:

ODZ84_06720

» show all

Reference

1 [PMID:23214453]

Authors

Hobbs ME, Vetting M, Williams HJ, Narindoshvili T, Kebodeaux DM, Hillerich B, Seidel RD, Almo SC, Raushel FM

Title

Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily.

Journal

Biochemistry 52:239-53 (2013)
DOI:10.1021/bi3015554

Sequence

[bmj:BMULJ_04919]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.435

IUBMB Enzyme Nomenclature:

1.1.1.435

ExPASy - ENZYME nomenclature database:

1.1.1.435

BRENDA, the Enzyme Database:

1.1.1.435

All links

Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (2362)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (503)   
   KEGG MGENES (1858)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (2)   
   InterPro (2)   
All databases (2378)   

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