KEGG   ENZYME: 1.1.1.437
Entry
EC 1.1.1.437                Enzyme                                 
Name
5-dehydrofumagillol 5-reductase;
af490 (gene name);
Fma-KR
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
fumagillol:NADP+ 5-oxidoreductase
Reaction(IUBMB)
fumagillol + NADP+ = 5-dehydrofumagillol + NADPH + H+ [RN:R13106]
Reaction(KEGG)
R13106
Substrate
fumagillol [CPD:C22618];
NADP+ [CPD:C00006]
Product
5-dehydrofumagillol [CPD:C22619];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the mold Aspergillus fumigatus, participates in the biosynthesis of the meroterpenoid fumagillin. It is a partial polyketide synthase (PKS) consisting of only a dehydratase (DH) and a ketoreductase (KR) domain.
History
EC 1.1.1.437 created 2022
Pathway
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22572  5-dehydrofumagillol 5-reductase
Genes
AFM: AFUA_8G00490
Reference
1  [PMID:24568283]
  Authors
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
  Title
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
  Journal
J Am Chem Soc 136:4426-36 (2014)
DOI:10.1021/ja500881e
  Sequence
[afm:AFUA_8G00490]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.437
IUBMB Enzyme Nomenclature: 1.1.1.437
ExPASy - ENZYME nomenclature database: 1.1.1.437
BRENDA, the Enzyme Database: 1.1.1.437

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (8)   
   InterPro (8)   
All databases (25)   

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