Entry
Name
methylglyoxal reductase (NADH);
methylglyoxal reductase;
D-lactaldehyde dehydrogenase;
methylglyoxal reductase (NADH-dependent)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-lactaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
(R)-lactaldehyde + NAD+ = 2-oxopropanal + NADH + H+ [RN:
R02527 ]
Reaction(KEGG)
Substrate
Product
Comment
This mammalian enzyme differs from the yeast enzyme, EC
1.1.1.283 , methylglyoxal reductase (NADPH), by its cosubstrate requirement, reaction direction, and enantiomeric preference.
History
EC 1.1.1.78 created 1972, modified 2005, modified 2013
Pathway
Reference
Authors
TING SM, MILLER ON, SELLINGER OZ.
Title
THE METABOLISM OF LACTALDEHYDE. VII. THE OXIDATION OF D-LACTALDEHYDE IN RAT LIVER.
Journal
Reference
Authors
Ray M, Ray S
Title
Purification and partial characterization of a methylglyoxal reductase from goat liver.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.78
ExPASy - ENZYME nomenclature database: 1.1.1.78