Entry
Name
diiodophenylpyruvate reductase;
aromatic alpha-keto acid;
KAR;
2-oxo acid reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase
Reaction(IUBMB)
3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH + H+ [RN:
R03431 ]
Reaction(KEGG)
Substrate
3-(3,5-diiodo-4-hydroxyphenyl)lactate [CPD:
C04367 ];
NAD+ [CPD:
C00003 ]
Product
Comment
Substrates contain an aromatic ring with a pyruvate side chain. The most active substrates are halogenated derivatives. Compounds with hydroxy or amino groups in the 3 or 5 position are inactive.
History
EC 1.1.1.96 created 1972
Reference
Authors
Zannoni VG, Weber WW.
Title
Isolation and properties of aromatic alpha-keto acid reductase.
Journal
J Biol Chem 241:1340-4 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.96
ExPASy - ENZYME nomenclature database: 1.1.1.96