KEGG   ENZYME: 1.1.2.2
Entry
EC 1.1.2.2                  Enzyme                                 
Name
mannitol dehydrogenase (cytochrome);
polyol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a cytochrome as acceptor
Sysname
D-mannitol:cytochrome-c 2-oxidoreductase
Reaction(IUBMB)
D-mannitol + a ferricytochrome c = D-fructose + a ferrocytochrome c + 2 H+ [RN:R00865]
Reaction(KEGG)
R00865;
(other) R01892
Substrate
D-mannitol [CPD:C00392];
ferricytochrome c [CPD:C00125]
Product
D-fructose [CPD:C00095];
ferrocytochrome c [CPD:C00126];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Gluconobacter oxydans acts on polyols with a D-lyxo configuration, such as D-mannitol and D-sorbitol, with preference towards the former.
History
EC 1.1.2.2 created 1961
Pathway
ec00040  Pentose and glucuronate interconversions
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:13373782]
  Authors
ARCUS AC, EDSON NL.
  Title
Polyol dehydrogenases.  2.  The polyol dehydrogenases of Acetobacter suboxydans and Candida utilis.
  Journal
Biochem J 64:385-94 (1956)
DOI:10.1042/bj0640385
Reference
2
  Authors
Cho, N.C., Kim, K. and Jhon, D.Y.
  Title
Purification and characterization of polyol dehydrogenase from Gluconobacter melanogenus.
  Journal
Han'guk Saenghwa Hakhaochi 23:172-178 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.2.2
IUBMB Enzyme Nomenclature: 1.1.2.2
ExPASy - ENZYME nomenclature database: 1.1.2.2
BRENDA, the Enzyme Database: 1.1.2.2
CAS: 37250-78-5

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Pathway (6)   
   KEGG PATHWAY (6)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Protein sequence (3)   
   UniProt (3)   
DNA sequence (46)   
   GenBank (23)   
   EMBL (23)   
All databases (66)   

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