KEGG ENZYME: 1.1.3.40

ENZYME: 1.1.3.40

Entry

EC 1.1.3.40                 Enzyme

Name

D-mannitol oxidase;
mannitol oxidase;
D-arabitol oxidase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor

Sysname

mannitol:oxygen oxidoreductase (cyclizing)

Reaction(IUBMB)

D-mannitol + O2 = D-mannose + H2O2 [RN:R05698]

Reaction(KEGG)

R05698

Substrate

D-mannitol [CPD:C00392];
O2 [CPD:C00007]

Product

D-mannose [CPD:C00159];
H2O2 [CPD:C00027]

Comment

Also catalyses the oxidation of D-arabinitol and, to a lesser extent, D-glucitol (sorbitol), whereas L-arabinitol is not a good substrate. The enzyme from the snails Helix aspersa and Arion ater is found in a specialised tubular organelle that has been termed the mannosome.

History

EC 1.1.3.40 created 2001

Reference

1 [PMID:3519307]

Authors

Vorhaben JE, Smith DD Jr, Campbell JW.

Title

Mannitol oxidase: partial purification and characterization of the membrane-bound enzyme from the snail Helix aspersa.

Journal

Int J Biochem 18:337-44 (1986)
DOI:10.1016/0020-711x(86)90039-x

Reference

Authors

Malik, Z., Jones, C.J.P. and Connock, M.J.

Title

Assay and subcellular localization of H2O2 generating mannitol oxidase in the terrestrial slug Arion ater.

Journal

J Exp Zool 242:9-15 (1987)

Reference

Authors

Large, A.T., Jones, C.J.P. and Connock, M.J.

Title

The association of mannitol oxidase with a distinct organelle in the digestive gland of the terrestrial slug Arion ater.

Journal

Protoplasma 175:93-101 (1993)

Reference

4 [PMID:29529078]

Authors

Lobo-da-Cunha A, Amaral-de-Carvalho D, Oliveira E, Alves A, Costa V, Calado G

Title

Mannitol oxidase and polyol dehydrogenases in the digestive gland of gastropods: Correlations with phylogeny and diet.

Journal

PLoS One 13:e0193078 (2018)
DOI:10.1371/journal.pone.0193078

Other DBs

ExplorEnz - The Enzyme Database:

1.1.3.40

IUBMB Enzyme Nomenclature:

1.1.3.40

ExPASy - ENZYME nomenclature database:

1.1.3.40

BRENDA, the Enzyme Database:

1.1.3.40

CAS:	73562-29-5

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (4)   
   UniProt (4)   
All databases (10)   

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