KEGG   ENZYME: 1.1.3.44
Entry
EC 1.1.3.44                 Enzyme                                 
Name
6'''-hydroxyneomycin C oxidase;
neoG (gene name);
neoQ (obsolete gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
6'''-deamino-6'''-hydroxyneomycin C:oxygen 6'''-oxidoreductase
Reaction(IUBMB)
6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2 [RN:R08902]
Reaction(KEGG)
R08902
Substrate
6'''-deamino-6'''-hydroxyneomycin C [CPD:C17588];
O2 [CPD:C00007]
Product
6'''-deamino-6'''-oxoneomycin C [CPD:C17589];
H2O2 [CPD:C00027]
Comment
Contains FAD. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 2.6.1.95, neomycin C transaminase, to replace the 6'''-hydroxy group of 6'''-hydroxyneomycin C with an amino group.
Also catalyses EC 1.1.3.43, paromamine 6'-oxidase.
History
EC 1.1.3.44 created 2012
Pathway
ec00524  Neomycin, kanamycin and gentamicin biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20565  paromamine 6'-oxidase / 6'''-hydroxyneomycin C oxidase
Genes
SRN: A4G23_05124(neoG)
SFB: CP974_27345
DMAT: Dmats_04980
Reference
1  [PMID:17206729]
  Authors
Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB
  Title
Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin.
  Journal
Chembiochem 8:283-8 (2007)
DOI:10.1002/cbic.200600371
Reference
2  [PMID:21689223]
  Authors
Clausnitzer D, Piepersberg W, Wehmeier UF
  Title
The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin.
  Journal
J Appl Microbiol 111:642-51 (2011)
DOI:10.1111/j.1365-2672.2011.05082.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.44
IUBMB Enzyme Nomenclature: 1.1.3.44
ExPASy - ENZYME nomenclature database: 1.1.3.44
BRENDA, the Enzyme Database: 1.1.3.44

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (4)   
Protein sequence (10)   
   UniProt (9)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (29)   

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